Abstract
Background: The aim of the study was to determine if physical activity (PA) is associated with bone health in children with Prader-Willi syndrome (PWS).
Methods: Participants included 23 children with PWS (age: 11.0±2.0 years). PA, measured by accelerometry, was categorized into light, moderate, vigorous and moderate plus vigorous intensities. Hip, total body minus the head (body), bone mineral content (BMC), bone mineral density (BMD) and BMD z-score (BMDz) were measured by dual X-ray absorptiometry. Separate hierarchical regression models were completed for all bone parameters, PA intensity and select covariates.
Results: Moderate PA and select covariates explained the most variance in hip BMC (84.0%), BMD (61.3%) and BMDz (34.9%; p<0.05 for all). Likewise, for each body parameter, moderate PA and select covariates explained the most variance in body BMC (75.8%), BMD (74.4%) and BMDz (31.8%; p<0.05 for all).
Conclusions: PA of at least moderate intensity appears important for BMC and BMD in children with PWS.
Acknowledgments:
The authors would like to thank the families that participated.
Research funding: This study was funded by the United States Army Medical Research and Materiel Command Award W81XWH-09-1-0682.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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