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Licensed Unlicensed Requires Authentication Published by De Gruyter December 16, 2015

Association between circulating CCL2 levels and modifiable behaviors in overweight and obese adolescents: a cross-sectional pilot study

Mackenzie J. Bodo , Elizabeth Yakes Jimenez , Carole Conn , Alyssa Dye , Page Pomo , Deborah Kolkmeyer , Robert Orlando and Alberta S. Kong EMAIL logo

Abstract

Background: We evaluated the relationship between an early inflammatory biomarker, chemokine (C-C motif) ligand 2 (CCL2), and other clinical biomarkers and lifestyle behaviors, in overweight/obese adolescents at high risk of developing cardiometabolic derangements.

Methods: We collected anthropometric measurements, clinical biomarkers, and three 24-h dietary recalls from 21 vocational high school students (91% male), 14–19 years, with body mass index (BMI) ≥25 kg/m2. Pearson’s or Spearman’s correlation coefficients were used to examine relationships.

Results: Mean BMI was 33.2 kg/m2 (range 25.7–45.6) and 38% were prediabetic by fasting glucose. Mean CCL2 was 512.9 pg/mL (range 220–917) and positively correlated with triglycerides (r=0.45; p=0.04) and TNF-α (r=0.57; p=0.007) and marginally negatively correlated with fruit/vegetable intake (r=–0.42, p=0.06) and omega-3 fatty acids (r=–0.41, p=0.07).

Conclusions: CCL2 was positively associated with pro-inflammatory biomarkers and negatively associated with some anti-inflammatory dietary factors.


Corresponding author: Dr. Alberta S. Kong, MSC 10 5590, 1 University of New Mexico, Albuquerque, NM, 87131, USA;

Acknowledgments

This study was supported by a La Tierra Sagrada Society Community Grant and by CTSC grant DHHS/NIH/NCRR #8UL1TR000041. We sincerely appreciate the participating students and the support we received from the school and school health clinic staff, especially Zach Chavez, Keith Haynie, James Shoemate and Tori Stephens-Shauger. We are also grateful for the contributions of Amanda Harris from the UNM Division of Adolescent Medicine in the Department of Pediatrics, Sarah Sanders from the UNM Prevention Research Center, and Amanda Hernandez, Valerie Vieira, and Brittany Mally from the UNM Nutrition Program to data collection.

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: See Acknowledgments section above.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2015-6-29
Accepted: 2015-10-27
Published Online: 2015-12-16
Published in Print: 2016-4-1

©2016 by De Gruyter

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