Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter August 22, 2016

Factors associated with post-menarcheal growth: results of a longitudinal study in Chilean girls from different socioeconomic statuses

  • Ximena Gaete EMAIL logo , Patricia López , Nancy Unanue , Ethel Codner , Gabriel Cavada and Verónica Mericq



Menarche is the last stage of pubertal development, which coincides, with the completion of longitudinal growth. Our aim was to evaluate, post-menarcheal growth and clinical variables proposed to be associated with this growth.


In a prospective fashion, 106 healthy girls attending five different socioeconomic status (SES) schools of Santiago were randomly recruited. A pediatric endocrinologist obtained anthropometrics and registration of date at menarche every 6 months. The evolution of the girls’ heights was assessed through mixed models adjusted to the SESes, parental height and body mass index (BMI).


Sixty-three girls from a high socioeconomic status (HSS) and 50 from a low socioeconomic status (LSS) were followed. Four years post menarche, the girls reached a growth plateau and the average height gain was 5.2±2.5 cm. This gain was not associated with SES, BMI, nor with parental height (p=0.744). The only variable that modulated this gain was age at menarche (r=−0.1997, p=0.0332). There was an inverse correlation between height at the moment of menarche and the height reached after 4 years of follow-up adjusted to parental height (r=−0302, p=0.0011).


Post-menarcheal growth ends 4 years post-event and is inversely correlated with the age at menarche and with the height at the moment of menarche independent of BMI, parental height and SES.

  1. Author contributions:All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership:None declared.

  4. Honorarium: None declared.

  5. Competing interests:The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


1. Cameron N, Bogin B, editors. Growth in infancy and childhood. Human growth and development, 2nd ed. London: Elsevier, 2012.Search in Google Scholar

2. Tanner JM. Growth at adolescence. Oxford: Blackwell Scientific Publications, 1962.Search in Google Scholar

3. Roche A, Davila GH. Late adolescent growth in stature. Pediatrics 1972;50:874–80.10.1542/peds.50.6.874Search in Google Scholar

4. Crespin J. Height at menarche and adult height. Restrospective study in 120 adolescents. Ped Mod 1999;35:403–10.Search in Google Scholar

5. Avendaño-Bertoló A, Valenzuela-Yuraidini C, BernierP, Walton-Larraguibel R. Growth related to menarche in middle and low socioeconomic status. Rev Chil Pediatr 1989;60:211–4.Search in Google Scholar

6. Sorensen K, Mouritsen A, Aksglaede L, Hagen C, Mogensen S, et al. Recent secular trends in pubertal timing: implications for evaluation and diagnosis of precocious puberty. Horm Res Paediatr 2012;77:137–45.10.1159/000336325Search in Google Scholar

7. Cabrera SM, Bright GM, Frane JW, Blethen SL, Lee PA. Age of thelarche and menarche in contemporary US females: a cross-sectional analysis. J Pediatr Endocrinol Metab 2014;27:47–51.10.1515/jpem-2013-0286Search in Google Scholar

8. Lui JC, Nilsson O. Growth plate senescence and catch-up growth. Endocr Dev 2011;21:23–9.10.1159/000328117Search in Google Scholar

9. Fried RI, Smith EE. Post menarcheal growth patterns. J Pediatr 1962;61:562–5.10.1016/S0022-3476(62)80147-4Search in Google Scholar

10. Kaplan LS. Phases of growth. In: Rudolph A, Barnett H, Einborn A, editors. Pediatric 16th edition. New York: Appleton-Cetury-Crofts, 1977;109–11.Search in Google Scholar

11. Singleton A, Patois E, Pedron M, Roy P. Increment in height of the upper segment and bi-iliac diameter after menarche in young girls. Longitudinal study of 40 adolescents. Arch Franç Péd 1975;32:859–70.Search in Google Scholar

12. Tanner JM. Normal growth and techniques of growth assessment. Clin Endocrinol Metab 1986;15:411–51.10.1016/S0300-595X(86)80005-6Search in Google Scholar

13. Cravioto J, Cravito P, Bravo G, Fernandez G, López D, et al. Height increment post menarche in a rural Mexican population. Invest Clin 1988;40:220–30.Search in Google Scholar

14. Diez Castilho S, Saito M, Barros A. Growth in a cohort of Brazilian girls. Arq Bras Endocrinol Metab 2005;49:971–7.Search in Google Scholar

15. Amigo H, Lara M, Bustos P, Muñoz S. Post menarche growth: cohort study among indigenous and non-indigenous Chilean adolescents. BMC Public Health 2015;15:51.10.1186/s12889-015-1389-ySearch in Google Scholar

16. Frish RE, Nagel JS. Prediction of adult height of girls from age of menarche and height at menarche. J Pediatr 1974;85:838–41.10.1016/S0022-3476(74)80356-2Search in Google Scholar

17. Tanner JM, Whitehouse RH, Marshall WA, Carter BS. Prediction of adult height from height, bone age, and occurrence of menarche, at ages 4 to 16 with allowance for mid parent height. Arch Dis Child 1975;50:14–26.10.1136/adc.50.1.14Search in Google Scholar

18. Tanner JM, Davies PS. Clinical longitudinal standards for height and height velocity for North American children. J Pediatr 1985;107:317–29.10.1016/S0022-3476(85)80501-1Search in Google Scholar

19. Lowrey GH. Growth and development of children. Chicago: Year Book Medical Publishers, 1986.Search in Google Scholar

20. Tanner JM. Fetus into man. Ware: Castlemead, 1989.Search in Google Scholar

21. Wang Y. Is obesity associated with early sexual maturation? A comparison of the association in American boys versus girls. Pediatrics 2002;110:903–10.10.1542/peds.110.5.903Search in Google Scholar PubMed

22. Mandel D, Zimlichman E, Mimouni FB, Grotto J, Kreiss Y. Age at menarche and body mass index: a population study. J Pediatr Endocrinol Metab 2004;17:1507–10.10.1515/JPEM.2004.17.11.1507Search in Google Scholar PubMed

23. Jaruratanasirikul S, Thongkum K, Krisaneepaiboon S, Sriplung H. Girls with early puberty attain a near–final height similar to their target height. J Pediatr Endocrinol Metab 2011;24:339–45.10.1515/jpem.2011.005Search in Google Scholar PubMed

24. Bralić I, Tahirović H, Matanić D, Vrdoljak O, Stojanović-Spehar S, et al. Association of early menarche age and overweight/obesity. J Pediatr Endocrinol Metab 2012;25:57–62.10.1515/jpem-2011-0277Search in Google Scholar PubMed

25. Hernández MI, Unanue N, Gaete X, Cassorla F, Codner E. Age of menarche and its relationship with body mass index and socioeconomic status. Rev Med Chil 2007;135:1429–36.Search in Google Scholar

26. Bau AM, Ernet A, Schenk L, Wiegand S, Martus P, et al. Is there a further acceleration in the age at onset of menarche? A cross sectional study in 1849 school children focusing on age and bodyweight at the onset of menarche. Eur J Endocrinol 2009;160:107–13.10.1530/EJE-08-0594Search in Google Scholar PubMed

27. Amigo H, Bustos P, Muzzo S, Alarcón AM, Muñoz S. Age at menarche and nutritional status of indigenous and non indigenous adolescents in the Araucania Region of Chile. Ann Hum Biol 2010;37:554–61.10.3109/03014460903456324Search in Google Scholar PubMed

Received: 2016-2-1
Accepted: 2016-7-18
Published Online: 2016-8-22
Published in Print: 2016-9-1

©2016 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 7.6.2023 from
Scroll to top button