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Licensed Unlicensed Requires Authentication Published by De Gruyter December 19, 2016

Plasma concentrations of osteocalcin are associated with the timing of pubertal progress in boys

Michael M. Schündeln, Lena Bäder, Cordula Kiewert, Ralf Herrmann, Dagmar Führer, Berthold P. Hauffa and Corinna Grasemann

Abstract

Background:

Animal models have shown that the skeletal hormone osteocalcin stimulates testicular testosterone synthesis. To assess whether osteocalcin might be a useful marker to detect pubertal development disorders, we examined osteocalcin plasma concentrations in children and adolescents with and without disorders of pubertal development.

Methods:

Osteocalcin concentrations were investigated in a total of 244 patients with endocrine disorders (122 males, mean age: 11.87+3.77 years), including patients with precocious puberty and constitutional delay of puberty.

Results:

Osteocalcin concentrations were highest among adolescents with precocious puberty and advanced pubertal development (120.60±45.22 ng/mL), while the concentrations were lowest among patients with constitutional delay of puberty (102.20±37.13 ng/mL). Overall, osteocalcin concentrations were strongly correlated with markers of bone metabolism.

Conclusions:

Although plasma osteocalcin concentrations are associated with pubertal development in boys, it does not appear to be a useful diagnostic marker for altered pubertal development.


Corresponding author: Corinna Grasemann, MD, Pediatric Endocrinology and Diabetology, Klinik für Kinderheilkunde II, Universitätsklinikum Essen and The University of Duisburg-Essen Hufelandstr. 55, 45122 Essen, Germany

Acknowledgments

The authors thank Sandy Moore, from Marseille, France, for editorial assistance with the manuscript.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Supplemental Material:

The online version of this article (DOI: 10.1515/jpem-2016-0243) offers supplementary material, available to authorized users.


Received: 2016-6-16
Accepted: 2016-11-11
Published Online: 2016-12-19
Published in Print: 2017-2-1

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