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Licensed Unlicensed Requires Authentication Published by De Gruyter December 19, 2016

Plasma concentrations of osteocalcin are associated with the timing of pubertal progress in boys

  • Michael M. Schündeln , Lena Bäder , Cordula Kiewert , Ralf Herrmann , Dagmar Führer , Berthold P. Hauffa and Corinna Grasemann EMAIL logo



Animal models have shown that the skeletal hormone osteocalcin stimulates testicular testosterone synthesis. To assess whether osteocalcin might be a useful marker to detect pubertal development disorders, we examined osteocalcin plasma concentrations in children and adolescents with and without disorders of pubertal development.


Osteocalcin concentrations were investigated in a total of 244 patients with endocrine disorders (122 males, mean age: 11.87+3.77 years), including patients with precocious puberty and constitutional delay of puberty.


Osteocalcin concentrations were highest among adolescents with precocious puberty and advanced pubertal development (120.60±45.22 ng/mL), while the concentrations were lowest among patients with constitutional delay of puberty (102.20±37.13 ng/mL). Overall, osteocalcin concentrations were strongly correlated with markers of bone metabolism.


Although plasma osteocalcin concentrations are associated with pubertal development in boys, it does not appear to be a useful diagnostic marker for altered pubertal development.

Corresponding author: Corinna Grasemann, MD, Pediatric Endocrinology and Diabetology, Klinik für Kinderheilkunde II, Universitätsklinikum Essen and The University of Duisburg-Essen Hufelandstr. 55, 45122 Essen, Germany


The authors thank Sandy Moore, from Marseille, France, for editorial assistance with the manuscript.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


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Supplemental Material:

The online version of this article (DOI: 10.1515/jpem-2016-0243) offers supplementary material, available to authorized users.

Received: 2016-6-16
Accepted: 2016-11-11
Published Online: 2016-12-19
Published in Print: 2017-2-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

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