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Licensed Unlicensed Requires Authentication Published by De Gruyter January 11, 2017

High predictability of impaired glucose tolerance by combining cardiometabolic screening parameters in obese children

Cornelis Jan de Groot, Jeroen van der Grond, Yosine Delgado, Edmond H.H.M. Rings, Sabine E. Hannema and Erica L.T. van den Akker

Abstract

Background:

There is debate on which overweight and obese children should be screened for the presence of impaired glucose tolerance (IGT) by oral glucose tolerance testing (OGTT). The objective of the study was to identify risk factors predictive of the presence of IGT.

Methods:

In a cohort of overweight children, who underwent OGTT, we determined the association of anthropometric and laboratory parameters with IGT and whether combining parameters improved the sensitivity of screening for IGT.

Results:

Out of 145 patients, IGT was present in 11, of whom two had impaired fasting glucose (IFG). Elevated blood pressure (p=0.025) and elevated liver enzymes (p=0.003) were associated with IGT, whereas IFG was not (p=0.067), screening patients with either one of these parameters predicted IGT with a high sensitivity of 1.00, and a number needed to screen of 5.7.

Conclusions:

Screening all patients with either IFG, presence of elevated blood pressure and elevated liver enzymes, significantly increases predictability of IGT compared to using IFG alone.

Acknowledgments

The authors would like to express their gratitude to Prof. Dr. H.A. Delemarre-van de Waal for her efforts invested in setting up the obesity outpatient clinic in the Willem-Alexander Children Hospital and for facilitating the set-up of this study. Prof. Delemarre deceased 13th of February 2014. Furthermore, we would like to thank Drs. A. Felius, for his support in the clinical part of this study.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. Corjan de Groot: Drs. de Groot conceptualized and designed the study, collected and analyzed the data and drafted the initial manuscript. Jeroen van der Grond: Dr. van der Grond provided extensive support in data analysis, edited the initial manuscript and critically reviewed the final manuscript. Yosine Delgado: Ms. Delgado collected the data, was involved in analyzing the data and critically reviewed the final manuscript. Edmond Rings: Prof. dr. Rings supervised the project and critically reviewed the final manuscript. Sabine Hannema: Dr. Hannema had valuable input on the design of the study and analysis of the data and critically reviewed the final version of the manuscript. Erica van den Akker: Dr. van den Akker had valuable input on the design of the study, the analysis of data, editing of the initial manuscript and critically reviewed the final version of the manuscript.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2016-7-19
Accepted: 2016-11-21
Published Online: 2017-1-11
Published in Print: 2017-2-1

©2017 Walter de Gruyter GmbH, Berlin/Boston