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Licensed Unlicensed Requires Authentication Published by De Gruyter May 11, 2018

Definition of reference ranges for β-isomerized carboxy-terminal telopeptide collagen type I for children and adolescents

Veronica C.P. de Melo, Paulo R.S. Ferreira, Lucelia O. Ricardi, Marcelo C. Batista, Carolina N. França and Carlos E. dos S. Ferreira



Bone metabolism involves many complex pathways that are disturbed by several bone diseases. The literature shows some limitations concerning pediatric reference intervals to bone markers, mainly because of the low number of patients included in the studies, the heterogeneity of methods, beyond the fact that it is time-consuming and expensive. The aim of this study was to determine reference values for β-isomerized carboxy-terminal telopeptides collagen type I (β-CTX), a marker of bone resorption, for children and adolescents.


Blood samples from 246 patients were collected and β-CTX was measured using an electrochemiluminescence immunoassay (ECLI).

Results and conclusions:

We propose reference ranges for β-CTX concentration from the 2.5 percentile and 97.5 percentile for each age group. The reference values obtained, concerning children and adolescents, might be useful in the evaluation of diseases such as osteosarcoma and anorexia in both childhood as adolescence.

Corresponding author: Carlos E. dos S. Ferreira, PhD, Hospital Israelita Albert Einstein, Albert Einstein Avenue, 625 to 701, São Paulo, SP, Brazil, Phone: +55 1198451 9909

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


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Received: 2018-1-2
Accepted: 2018-4-3
Published Online: 2018-5-11
Published in Print: 2018-6-27

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