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Licensed Unlicensed Requires Authentication Published by De Gruyter February 2, 2019

Physical growth and development characteristics of children with Williams syndrome aged 0–24 months in Zhejiang Province

Dan Yao, Chai Ji, Weijun Chen, Mingyan Li and Zheng-Yan Zhao



The objective of this study was to evaluate the physical growth and development characteristics of children with Williams syndrome (WS) aged 0–24 months, and provide help for early diagnosis of WS.


A total of 32 cases of children (17 males and 15 females) aged 0–24 months who were diagnosed with WS were enrolled between 2008 and 2017. These children were divided into four different groups: 1–6 months (six cases), 7–12 months (eight cases), 12–18 months (nine cases) and 19–24 months (nine cases). Meanwhile, a total of 32 healthy children (17 males and 15 females) were enrolled in the study from the Department of Health Care for physical examination in our hospital as the control group and matched with each divided group. Weight and height were measured, and meanwhile birth weight and height were also asked and recorded.


There was no statistically significant difference in birth height between the two groups (p>0.05), and birth weight and the height and weight of the children with WS in the four groups were significantly lower than those of the children in the normal control (NC) group (p>0.05). When the corresponding age of WS children was compared to the Nine City Growth Curve Standards in China, 97% of cases were lagging behind in physical growth and development.


WS children often have the features of early slow physical growth, which provides certain help for the early diagnosis of WS. Therefore, for younger children, facial features combined with an accurate and objective physical growth assessment and ultrasonic cardiogram can greatly improve the screening rate.

Corresponding author: Zheng-Yan Zhao, MM, Department of Pediatric Health Care, The Children’s Hospital, Zhejiang University School of Medicine, 57 Zhugan Lane, Yanan Road, Hangzhou, Zhejiang 310003, China, Phone: 0086-571-87064482, Fax: 0086-571-87033296

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


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Received: 2018-04-30
Accepted: 2018-12-16
Published Online: 2019-02-02
Published in Print: 2019-03-26

©2019 Walter de Gruyter GmbH, Berlin/Boston

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