Accessible Requires Authentication Published by De Gruyter February 9, 2019

Validation of the Greek version of the Quality of Life in Short Stature Youth (QoLISSY) questionnaire

Chrysoula Drosatou, Elpis-Athina Vlachopapadopoulou, Monika Bullinger, Julia Quitmann, Neuza Silva, Georgia Salemi, Ioanna Pavlopoulou ORCID logo, Stefanos Michalacos and Konstantinos Tsoumakas

Abstract

Background

The Quality of Life in Short Stature Youth (QoLISSY) questionnaire is a condition-specific instrument for measuring the health-related quality of life (HRQoL) in short statured children/adolescents from patients’ and parents’ perspectives. The aim of this study was to investigate the psychometric properties of the Greek version of the QoLISSY questionnaire.

Methods

The original European QoLISSY scales were translated into Greek following the guidelines for linguistic validation and applied to 184 dyads of children 8–18 years old and their parents, as well as to 14 parents of children 4–7 years old in Greece. The field testing responses to the Greek version of QoLISSY were analyzed.

Results

The qualitative analysis of the Greek data provided results consistent with the European sample. The subsequent field test showed acceptable internal consistency (Cronbach α between 0.67–0.93) and high test-retest reliability (intraclass correlation coefficients [ICC] ≥0.70). Correlations with the generic KIDSCREEN questionnaire indicated good convergent validity. Confirmatory factor analysis (CFA) also yielded acceptable results. Higher HRQoL for taller children suggests that QoLISSY was able to detect significant height-related differences.

Conclusions

The Greek version of the QoLISSY questionnaire is psychometrically sound and its use is recommended in further clinical research to ascertain the impact of short stature (SS) and treatments in Greek children/adolescents and families.

Acknowledgments

The authors would like to thank the QoLISSY study group and the participating families and staff of the clinical center for their support and contributions, as well as Dr Apostolos Prodromidis for his contribution to the study design, for providing a courtesy review and proof-reading of the manuscript and Ms Chara Tzavara for her contribution to the statistical analysis.

  1. Availability of data and supporting materials: Access to the QoLISSY instrument: QoLISSY is a joint initiative between Pfizer and the University Medical Center Hamburg – Eppendorf. Copyright Pfizer Limited all rights reserved. The European QoLISSY instrument, together with comprehensive information of its development and validation process, is published in the QoLISSY User’s Manual (Pabst Science Publishers, Lengerich, 2013). The manual, which is available upon request, includes QoLISSY child and parent forms, as well as scoring information.

  2. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Individual contributions: Designed the study: CD, MB, JQ and SM. Participated in the instrument translation: CD, EV and IP. Provided patient access and clinical data: EV and SM. Collected data: CD, EV and GS. Supervised the study design and data collection: KT. Managed data entry: CD and IP. Performed the analysis: CD, NS and SM. Interpreted the results: CD, MB, JQ and NS. Wrote the draft manuscript: CD. Contributed to the preparation and review of the manuscript: EV, MB, JQ, NS, GS and KT.

  4. Ethical approval: The study has been approved by the appropriate Ethics Committees and has, therefore, been performed in accordance with the ethical standard laid down in the 1964 Declaration of Helsinki and its later amendments.

    Informed consent was obtained from all individual participants included in the study. Parents consented and children older than 8 gave assent.

  5. Research funding: None declared.

  6. Employment or leadership: None declared.

  7. Honorarium: None declared.

  8. Competing interests: None declared.

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Received: 2018-09-26
Accepted: 2018-12-16
Published Online: 2019-02-09
Published in Print: 2019-03-26

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