Accessible Requires Authentication Published by De Gruyter March 7, 2019

Adiposity and adipocytokines: the moderator role of cardiorespiratory fitness and pubertal stage in girls

Caroline Brand, Neiva Leite, Wendell Arthur Lopes, Arieli Fernandes Dias, Larissa Rosa da Silva, Adroaldo Cezar Araujo Gaya, Jorge Mota, Claudia Regina Cavaglieri and Anelise Reis Gaya

Abstract

Background

Cardiorespiratory fitness (CRF) and pubertal stages have been related to many health outcomes, including obesity and adipocytokines. Thus, the present study aimed to analyze the moderator role of CRF and pubertal stage in the relationship between adiposity and adipocytokines in girls.

Method

This cross-sectional study was performed with 42 pre-pubertal girls aged from 7 to 11 years and 54 post-pubertal girls aged from 13 to 17 years. Blood samples were collected to determine the serum levels of leptin and adiponectin, and then the leptin/adiponectin ratio (L/A ratio) was calculated. CRF, anthropometric and body composition indicators were assessed. For statistical analysis, descriptive statistics and several linear regression models were used. The moderation analysis was tested using the PROCESS macro.

Results

An interaction between body mass index (BMI) and CRF (β: –0.70; confidence interval [CI]: –1.29, –0.12), as well as between BMI and pubertal stage (β: 0.79; CI: 0.28, 1.30) with leptin, was found. Regarding the L/A ratio, an interaction was found only in BMI × CRF (β: –0.56; CI: –1.06, –0.06). Using a combined interaction (CRF and pubertal stage), the results showed a positive association between BMI with leptin and L/A ratio only in low CRF, pre-pubertal and post-pubertal stages.

Conclusion

This study suggests a protective role of high levels of CRF in the relationship between BMI and adipocytokines. Despite the effect of pubertal stage, the results suggest that youth should be engaged in physical activity in order to improve CRF levels and consequently improve cardiometabolic health.

Acknowledgments

The authors acknowledge the research fellowship from the National Council for Scientific and Technological Development (CNPq) Brazil and The scholarships from the Coordination of Improvement of Higher Education Personnel (CAPES) Brazil. Foundation for Science and Technology (FCT), Portugal: SFRH/BSAB/142983/2018 and UID/DTP/00617/2019 as well as Santander University Scholarship Program 2018.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: National Council for Scientific and Technological Development, process number 401969/2016-9/, Funder Id: 10.13039/501100003593 Universal Announcement.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2018-09-22
Accepted: 2018-12-26
Published Online: 2019-03-07
Published in Print: 2019-03-26

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