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Licensed Unlicensed Requires Authentication Published by De Gruyter August 31, 2019

The effect of GnRH analogue treatment on bone mineral density in young adolescents with gender dysphoria: findings from a large national cohort

  • Tobin Joseph , Joanna Ting and Gary Butler EMAIL logo

Abstract

Background

More young people with gender dysphoria (GD) are undergoing hormonal intervention starting with gonadotropin-releasing hormone analogue (GnRHa) treatment. The impact on bone density is not known, with guidelines mentioning that bone mineral density (BMD) should be monitored without suggesting when. This study aimed to examine a cohort of adolescents from a single centre to investigate whether there were any clinically significant changes in BMD and bone mineral apparent density (BMAD) whilst on GnRHa therapy.

Methods

A retrospective review of 70 subjects aged 12–14 years, referred to a national centre for the management of GD (2011–2016) who had yearly dual energy X-ray absorptiometry (DXA) scans. BMAD scores were calculated from available data. Two analyses were performed, a complete longitudinal analysis (n=31) where patients had scans over a 2-year treatment period, and a larger cohort over the first treatment year (n=70) to extend the observation of rapid changes in lumbar spine BMD when puberty is blocked.

Results

At baseline transboys had lower BMD measures than transgirls. Although there was a significant fall in hip and lumbar spine BMD and lumbar spine BMAD Z-scores, there was no significant change in the absolute values of hip or spine BMD or lumbar spine BMAD after 1 year on GnRHa and a lower fall in BMD/BMAD Z-scores in the longitudinal group in the second year.

Conclusions

We suggest that reference ranges may need to be re-defined for this select patient cohort. Long-term BMD recovery studies on sex hormone treatment are needed.


Corresponding author: Professor Gary Butler, Department of Paediatric and Adolescent Endocrinology, University College London Hospital, 250 Euston Road, London NW1 2PQ, UK; UCL Great Ormond Street Institute of Child Health, London, UK; and Gender Identity Development Service, Tavistock and Portman NHS Trust, London, UK, Phone: +44 (0)20 344 79455

Acknowledgements

We are grateful to the staff from the Department of Nuclear Medicine UCLH for conducting the scans; colleagues from the National Adolescent Gender Identity Development Service, Tavistock and Portman NHS Trust for the assessment and referral of subjects; Elaine Perkins, Professor Russell Viner, Dr Elena Monti and the adolescent endocrine team at UCLH, and Professor Mary Fewtrell UCL for guidance on the analysis.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. The project was conceived by GB. Data collection and analysis was conducted by TJ and JT with input from GB as part of a UCL Medical School academic programme.

  2. Research funding: None. All scans were conducted as part of the NHS routine care programme.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organisation(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2019-01-22
Accepted: 2019-07-17
Published Online: 2019-08-31
Published in Print: 2019-10-25

©2019 Walter de Gruyter GmbH, Berlin/Boston

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