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Licensed Unlicensed Requires Authentication Published by De Gruyter August 27, 2020

Vitamin D status is related to severity at onset of diabetes and worse glycemic control

Raquel Segovia-Ortí ORCID logo, Antonia Barceló Bennassar, Diego de Sotto-Esteban and Pilar Sanchís Cortés



Our aim is to evaluate whether 25-hydroxyvitamin D at onset of type 1 diabetes mellitus (T1DM) would influence analytical variables of worse prognosis of the disease at the beginning and after one year of development.


A retrospective study of pediatric patients (0–14 years) diagnosed with T1DM with initial measurements of 25-hydroxyvitamin D was performed at Son Espases Hospital, between March 2012 and April 2019 (n=67).


Vitamin D insufficiency was related to age, glycosylated hemoglobin, and creatinine. An improvement in glycosylated hemoglobin was found in subjects whose baseline serum 25(OH)D was >30 ng/mL. Bivariate correlation analysis adjusted by age showed a significantly positive correlation of vitamin D with pH (r=0.279), bicarbonate (r=0.338), and free levothyroxine (r=0.293). Independent variables associated with vitamin D insufficiency were age (odds ratio [OR]=1.2) and winter season (OR=10.52).


Hypovitaminosis D is related to biochemical variables showing greater severity and higher glycosylated hemoglobin at diagnosis: higher creatinine, lower free levothyroxine, pH, and bicarbonate. Unsupplemented patients with baseline deficiency showed persistently worse glycemic control vs. those with baseline repletion.

Corresponding author: Raquel Segovia Ortí, Pediatrics, Son Espases University Hospital, Valldemossa Street 79, Palma, CP 07120, Majorca, Spain, Phone: 0034 606756666, E-mail:


The authors would like to thank Children’s Endocrinology Service of Son Espases Hospital for their outstanding collaboration for the data collection.

  1. Research funding: There is no funding source.

  2. Author Contributions: R.S.O. researched data and wrote the manuscript. D.S.E. and A.B.B. contributed to the discussion and reviewed. P.S.C. performed the statistical analysis. R.S.O. is guarantor of this work and had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

  3. Competing interests: The authors have no conflicts of interest to declare.

  4. Informed consent: Informed consent was not obtained from all individual participants included in the study because its retrospective observational design, where no personal data are collected, with minimal or no risk for the subjects, properly anonymize.

  5. Ethical approval: The study was approved by the Balearic Islands Research Ethics Committee (reference number: IB 3882/19 PI). Research was conducted ethically in accordance with the World Medical Association Declaration of Helsinki.


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Received: 2020-03-31
Accepted: 2020-06-04
Published Online: 2020-08-27

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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