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Licensed Unlicensed Requires Authentication Published by De Gruyter November 11, 2020

Longitudinal 15-year follow-up of women with former early puberty: abnormal metabolic profiles not associated with earlier age at onset of puberty, but associated with obesity

  • Somchit Jaruratanasirikul EMAIL logo , Pitchaya Satitpatanapan and Hutcha Sriplung



In 2011, we described 104 girls who were diagnosed as early puberty (EP) during 2003–2005. In 2019–2020, the former EP women had been followed up 14 years after attaining their final height.


To determine the reproductive function and metabolic profiles of former EP women.

Study design

Fifty-seven former EP women were evaluated for reproductive function and examined for health status. Blood samples were obtained for metabolic profiles of glucose, lipids and insulin, and testosterone levels.


In 2020, the average age of the study women was 22.9 ± 1.7 years. The average height was 156.7 ± 5.6 cm. The average weight had increased from 52.5 ± 7.8 kg in 2011 to 58.5 ± 11.1 kg in 2020 and average body mass index (BMI) from 21.4 ± 2.9 to 23.8 ± 4.0 kg/m2. Obesity (BMI>25 kg/m2) was found in 8.8% (five participants) in 2011 and had increased to 22.8% (13 participants) in 2020. Most participants (79%) had regular menstrual cycle. Of the 17 married women, 4 (23.5%) had 1–2 children. Dividing the participants into obese and nonobese groups, the average fasting plasma glucose, lipid profiles, and testosterone levels were similar in both groups. However, the average systolic blood pressure and the serum insulin levels and HOMA-IR assessments were significantly higher in the obese group than in the nonobese group.


The former EP women had normal menstruation and reproductive function. The former EP women with average BMI at the follow-up had normal metabolic profiles while those who later became obese had significantly higher systolic blood pressure, serum insulin, and HOMA-IR assessments.

Corresponding author: Somchit Jaruratanasirikul, MD, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110Thailand, Phone: +66 074 429618, Fax: +66 074 429618, E-mail:

Award Identifier / Grant number: 501100010804


This research was supported by the Research Funding Unit, Faculty of Medicine, Prince of Songkla University. The authors gratefully acknowledge the participants for participating in this study. The authors thank Mr. David Patterson from the International Affairs Office of the Faculty of Medicine, Prince of Songkla University, for editorial help.

  1. Research funding: Faculty of Medicine, Prince of Songkla University.

  2. Author contributions: Somchit Jaruratanasirikul: conceptualization, patient care and follow-ups, data collection, drafting the manuscript, editing and reviewing the manuscript. Pitchaya Satitpatanapan: data collection, drafting the manuscript. Hutcha Sriplung: data analysis, drafting the manuscript, editing and reviewing the manuscript.

  3. Competing interests: The funding organization played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The local Institutional Review Board deemed the study exempt from review.


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Received: 2020-06-10
Accepted: 2020-09-03
Published Online: 2020-11-11
Published in Print: 2021-01-27

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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