In 2011, we described 104 girls who were diagnosed as early puberty (EP) during 2003–2005. In 2019–2020, the former EP women had been followed up 14 years after attaining their final height.
To determine the reproductive function and metabolic profiles of former EP women.
Fifty-seven former EP women were evaluated for reproductive function and examined for health status. Blood samples were obtained for metabolic profiles of glucose, lipids and insulin, and testosterone levels.
In 2020, the average age of the study women was 22.9 ± 1.7 years. The average height was 156.7 ± 5.6 cm. The average weight had increased from 52.5 ± 7.8 kg in 2011 to 58.5 ± 11.1 kg in 2020 and average body mass index (BMI) from 21.4 ± 2.9 to 23.8 ± 4.0 kg/m2. Obesity (BMI>25 kg/m2) was found in 8.8% (five participants) in 2011 and had increased to 22.8% (13 participants) in 2020. Most participants (79%) had regular menstrual cycle. Of the 17 married women, 4 (23.5%) had 1–2 children. Dividing the participants into obese and nonobese groups, the average fasting plasma glucose, lipid profiles, and testosterone levels were similar in both groups. However, the average systolic blood pressure and the serum insulin levels and HOMA-IR assessments were significantly higher in the obese group than in the nonobese group.
The former EP women had normal menstruation and reproductive function. The former EP women with average BMI at the follow-up had normal metabolic profiles while those who later became obese had significantly higher systolic blood pressure, serum insulin, and HOMA-IR assessments.
Funding source: Faculty of Medicine, Prince of Songkla University
Award Identifier / Grant number: 501100010804
This research was supported by the Research Funding Unit, Faculty of Medicine, Prince of Songkla University. The authors gratefully acknowledge the participants for participating in this study. The authors thank Mr. David Patterson from the International Affairs Office of the Faculty of Medicine, Prince of Songkla University, for editorial help.
Research funding: Faculty of Medicine, Prince of Songkla University.
Author contributions: Somchit Jaruratanasirikul: conceptualization, patient care and follow-ups, data collection, drafting the manuscript, editing and reviewing the manuscript. Pitchaya Satitpatanapan: data collection, drafting the manuscript. Hutcha Sriplung: data analysis, drafting the manuscript, editing and reviewing the manuscript.
Competing interests: The funding organization played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: The local Institutional Review Board deemed the study exempt from review.
1. Sørensen, K, Mouritsen, A, Aksglaede, L, Hagen, CP, Mogensen, SS, Juul, A. Recent secular trends in pubertal timing: implications for evaluation and diagnosis of precocious puberty. Horm Res Paediatr 2012;77:137–45. https://doi.org/10.1159/000336325.Search in Google Scholar PubMed
2. Farello, G, Altieri, C, Cutini, M, Pozzobon, G, Verrotti, A. Review of the literature on current changes in the timing of pubertal development and the incomplete forms of early puberty. Front Pediatr 2019;7:147. https://doi.org/10.3389/fped.2019.00147.Search in Google Scholar PubMed PubMed Central
3. Moodie, JL, Campisi, SC, Salena, K, Wheatley, M, Vandermorris, A, Bhutta, ZA. Timing of pubertal milestones in low- and middle-income countries: a systematic review and meta-analysis. Adv Nutr 2020;11:951–9. https://doi.org/10.1093/advances/nmaa007.Search in Google Scholar PubMed PubMed Central
4. Eckert-Lind, C, Busch, AS, Petersen, JH, Biro, FM, Butler, G, Bräuner, EV, et al.. Worldwide secular trends in age at pubertal onset assessed by breast development among girls: a systematic review and meta-analysis. JAMA Pediatr 2020;174:e195881. doi:https://doi.org/10.1001/jamapediatrics.2019.5881.Search in Google Scholar PubMed PubMed Central
5. Jaruratanasirikul, S, Lebel, L. Ages at thelarche and menarche: study in southern Thai schoolgirls. J Med Assoc Thai 1995;78:516–20. https://doi.org/10.1007/s12519-014-0472-2.Search in Google Scholar PubMed
6. Mahachoklertwattana, P, Suthutvoravut, U, Charoenkiatkul, S, Chongviriyaphan, N, Rojroonwasinkul, N, Thakkinstian, A, et al.. Earlier onset of pubertal maturation in Thai girls. J Med Assoc Thai 2002;85 (4 Suppl):s1127–34.Search in Google Scholar
7. Jaruratanasirikul, S, Chanpong, A, Tassanakijpanich, N, Sriplung, H. Declining age of puberty of school girls in southern Thailand. World J Pediatr 2014;10:256–61. https://doi.org/10.1007/s12519-014-0472-2.Search in Google Scholar
8. Jaruratanasirikul, S, Sriplung, H. Secular trends of growth and pubertal maturation of school children in Southern Thailand. Ann Hum Biol 2015;42:447–54. https://doi.org/10.3109/03014460.2014.955057.Search in Google Scholar PubMed
9. Cassio, A, Cacciari, E, Balsamo, A, Bal, M, Tassarini, D. Randomised trial of LHRH analogue treatment on final height in girls with onset of puberty aged 7.5–8.5 years. Arch Dis Child 1999;81:329–32. https://doi.org/10.1136/adc.81.4.329.Search in Google Scholar PubMed PubMed Central
10. Bouvattier, C, Coste, J, Rodrigue, D, Teinturier, C, Carel, JC, Chaussain, JL, et al.. Lack of effect of GnRH agonists on final height in girls with advanced puberty: a randomized long-term pilot study. J Clin Endocrinol Metab 1999;84:3575–8. https://doi.org/10.1210/jcem.84.10.6032.Search in Google Scholar PubMed
11. Jaruratanasirikul, S, Thongkum, K, Krisaneepaiboon, S, Sriplung, H. Girls with early puberty attain a near-final height similar to their target height. J Pediatr Endocrinol Metab 2011;24:339–45. https://doi.org/10.1515/jpem.2011.005.Search in Google Scholar PubMed
12. Nutrition Division, Department of Health, Ministry of Public Health, Thailand. National growth references for children under 20 years of age. Bangkok, Thailand: Ministry of Public Health; 1999.Search in Google Scholar
16. Amiri, M, Ramezani Tehrani, F, Nahidi, F, Bidhendi Yarandi, R, Behboudi-Gandevani, S, Azizi, F. Association between biochemical hyperandrogenism parameters and Ferriman-Gallwey score in patients with polycystic ovary syndrome: a systematic review and meta-regression analysis. Clin Endocrinol 2017;87:217–30. https://doi.org/10.1111/cen.13389.Search in Google Scholar PubMed
17. Azziz, R, Carmina, E, Dewailly DAzziz, R, Carmina, E, Dewailly, D, Diamanti-Kandarakis, E, et al.. Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an androgen excess society guideline. J Clin Endocrinol Metab 2006;91:4237–45. https://doi.org/10.1210/jc.2006-0178.Search in Google Scholar PubMed
18. Matthews, DR, Hosker, JP, Rudenski, AS, Naylor, BA, Treacher, DF, et al.. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412–19. https://doi.org/10.1007/bf00280883.Search in Google Scholar
19. Lazar, L, Kauli, R, Pertzelan, A, Phillip, M. Gonadotropin-suppressive therapy in girls with early and fast puberty affects the pace of puberty but not total pubertal growth or final height. J Clin Endocrinol Metab 2002;87:2090–4. https://doi.org/10.1210/jcem.87.5.8481.Search in Google Scholar PubMed
20. Franzini, IA, Yamamoto, FM, Bolfi, F, Antonini, SR, Nunes-Nogueira, VS. GnRH analog is ineffective in increasing adult height in girls with puberty onset after seven years of age: a systematic review and meta-analysis. Eur J Endocrinol. 2018;179:381–90. https://doi.org/10.1530/eje-18-0473.Search in Google Scholar PubMed
21. Cassio, A, Bal, MO, Orsini, LF, Balsamo, A, Sansavini, S, Gennari, M, et al.. Reproductive outcome in patients treated and not treated for idiopathic early puberty: long-term results of a randomized trial in adults. J Pediatr 2006;149:532–6. https://doi.org/10.1016/j.jpeds.2006.05.026.Search in Google Scholar PubMed
22. Colmenares, A, Gunczler, P, Lanes, R. Higher prevalence of obesity and overweight without an adverse metabolic profile in girls with central precocious puberty compared to girls with early puberty, regardless of GnRH analogue treatment. Int J Pediatr Endocrinol 2014;2014:5. https://doi.org/10.1186/1687-9856-2014-5.Search in Google Scholar PubMed PubMed Central
23. Jaruratanasirikul, S, Thammaratchuchai, S, Puwanant, M, Mo-Suwan, L, Sriplung, H. Progression from impaired glucose tolerance to type 2 diabetes in obese children and adolescents: a 3–6-year cohort study in southern Thailand. J Pediatr Endocrinol Metab 2016;29:1267–75. https://doi.org/10.1515/jpem-2016-0195.Search in Google Scholar PubMed
24. Tirabanchasak, S, Siripunthana, S, Supornsilchai, V, Wacharasindhu, S, Sahakitrungruang, T. Insulin dynamics and biochemical markers for predicting impaired glucose tolerance in obese Thai youth. J Pediatr Endocrinol Metab 2015;28:1039–45. https://doi.org/10.1515/jpem-2014-0273.Search in Google Scholar PubMed
25. Di Bonito, P, Pacifico, L, Chiesa, C, Valerio, G, Miraglia Del Giudice, E, Maffeis, C, et al.. “CARdiometabolic risk factors in overweight and obese children in Italy” (CARITALY) study group. impaired fasting glucose and impaired glucose tolerance in children and adolescents with overweight/obesity. J Endocrinol Invest 2017;40:409–16. https://doi.org/10.1007/s40618-016-0576-8.Search in Google Scholar PubMed
26. Fobian, AD, Elliott, L, Louie, T. A systematic review of sleep, hypertension, and cardiovascular risk in children and adolescents. Curr Hypertens Rep 2018;20:42. https://doi.org/10.1007/s11906-018-0841-7.Search in Google Scholar PubMed PubMed Central
27. Turer, CB, Brady, TM, de Ferranti, SD. Obesity, hypertension, and dyslipidemia in childhood are key modifiable antecedents of adult cardiovascular disease: a call to action. Circulation 2018;137:1256–9. https://doi.org/10.1161/circulationaha.118.032531.Search in Google Scholar
28. Sun, X, Yang, L, Pan, J, Yang, H, Wu, Y, Chen, Z, et al.. Age at menarche and the risk of gestational diabetes mellitus: a systematic review and meta-analysis. Endocrine 2018;61:204–9. https://doi.org/10.1007/s12020-018-1581-9.Search in Google Scholar PubMed
29. Zhang, L, Li, Y, Wang, C, Mao, Z, Zhou, W, Tian, Z, et al.. Early menarche is associated with an increased risk of type 2 diabetes in rural Chinese women and is partially mediated by BMI: the henan rural cohort study. Menopause 2019;26:1265–71. https://doi.org/10.1097/gme.0000000000001385.Search in Google Scholar
30. Lee, JJ, Cook-Wiens, G, Johnson, BD, Braunstein, GD, Berga, SL, Stanczyk, FZ, et al.. Age at menarche and risk of cardiovascular disease outcomes: findings from the national heart lung and blood institute-sponsored women’s ischemia syndrome evaluation. J Am Heart Assoc 2019;8:e012406. https://doi.org/10.1161/jaha.119.012406.Search in Google Scholar
31. Kim, Y, Je, Y. Early menarche and risk of metabolic syndrome: a systematic review and meta-analysis. J Womens Health (Larchmt) 2019;28:77–86. https://doi.org/10.1089/jwh.2018.6998.Search in Google Scholar PubMed
32. Qiu, C, Chen, H, Wen, J, Zhu, P, Lin, F, Huang, B, et al.. Associations between age at menarche and menopause with cardiovascular disease, diabetes, and osteoporosis in Chinese women. J Clin Endocrinol Metab 2013;98:1612–21. https://doi.org/10.1210/jc.2012-2919.Search in Google Scholar PubMed
33. Shen, L, Wang, L, Hu, Y, Liu, T, Guo, J, Shen, Y, et al.. Associations of the ages at menarche and menopause with blood pressure and hypertension among middle-aged and older Chinese women: a cross-sectional analysis of the baseline data of the China health and retirement longitudinal study. Hypertens Res 2019;42:730–8. https://doi.org/10.1038/s41440-019-0235-5.Search in Google Scholar PubMed
34. Hwang, Y, Park, E, Kim, H, Park, S, Yoo, S. Relationship between age at menarche and metabolic syndrome in premenopausal women: Korea national health and nutrition examination survey 2013–2014. Korean J Fam Med 2018;39:300–6. https://doi.org/10.4082/kjfm.17.0022.Search in Google Scholar PubMed PubMed Central
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