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Licensed Unlicensed Requires Authentication Published by De Gruyter November 19, 2021

Psychiatric behavioral effect and characteristics of type 2 diabetes mellitus on Japanese patients with Prader-Willi syndrome: a preliminary retrospective study

  • Yuji Oto EMAIL logo , Nobuyuki Murakami , Takeshi Inoue , Keiko Matsubara , Sohei Saima , Hiroyuki Ogata , Hiroshi Ihara , Toshiro Nagai and Tomoyo Matsubara



In recent years, research on behavioral and psychiatric problems of adults with Prader-Willi syndrome (PWS) has gained attention. However, no report is available regarding the relationship between psychiatric illness and type 2 diabetes mellitus (T2DM) in patients with PWS. Therefore, we evaluated a behavioral assessment to address the lack of data on the association between psychiatric behavior and T2DM.


This was a retrospective single-center study of patients with PWS. Patients with PWS whose blood tests were performed in our hospital between January 2018 and December 2019 and aged >10 years were included. We evaluated the data, including the behavioral patterns of Japanese PWS patients with T2DM.


Overall, 114 patients were evaluated; 33 patients (28.9%) developed T2DM. The age of T2DM onset was 18.0 years (interquartile range [IQR], 14.6–21.4 years). The median body mass index at T2DM onset was 33.7 kg/m2 (IQR, 30.0–37.4 kg/m2). Between-group comparisons of the intelligence quotient, Food-Related Problem Questionnaire (FRPQ), and Japanese versions of the Short Sensory Profile and Aberrant Behavior Checklist showed a significant difference only in FRPQ scores (p=0.003).


The occurrence of T2DM among Japanese patients with PWS remains high. Only the FRPQ was significantly different between the T2DM and the non-T2DM group.

Corresponding author: Yuji Oto, Department of Pediatrics, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minamikoshigaya, Koshigaya City, Saitama 343-8555, Japan, Phone: +81-48-965-1111, Fax: +81-48-965-8363, E-mail:

Funding source: JSPS KAKENHI

Award Identifier / Grant number: 19K17375


We are grateful to the patients and their families for their willingness to participate in this study.

  1. Research funding: This work was supported by JSPS KAKENHI Grant Number 19K17375.

  2. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Competing interests: The funding organization(s) played no role in the study design, in the collection, analysis, and interpretation of data, in the writing of the report, or in the decision to submit the report for publication.

  4. Employment or leadership: None declared.

  5. Honorarium: None declared.

  6. Informed consent: Informed consent was obtained from all individuals included in this study.

  7. Ethical approval: The local Institutional Review Board deemed the study exempt from review.


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Received: 2021-08-24
Accepted: 2021-10-30
Published Online: 2021-11-19
Published in Print: 2022-01-27

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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