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Licensed Unlicensed Requires Authentication Published by De Gruyter October 5, 2022

Gender diversity in adolescents with polycystic ovary syndrome

  • Cintya L. Schweisberger , Laurie Hornberger , Romina Barral , Charles Burke , Emily Paprocki , Ashley Sherman , Heidi Vanden Brink and Tania S. Burgert EMAIL logo

Abstract

Objectives

The objective of our study was to describe the prevalence of gender diverse (GD) youth  among adolescents with polycystic ovary syndrome (PCOS).

Methods

We conducted a retrospective chart review on patients who met NIH criteria for PCOS in our Multidisciplinary Adolescent PCOS Program (MAPP). We compared those with PCOS to MAPP patients who did not meet PCOS criteria as well as to non-PCOS patients from the Adolescent Specialty Clinic (ASC). Variables analyzed included gender identity, androgen levels, hirsutism scores, and mood disorders. We used chi-square, Fisher’s exact, t-tests, and Wilcoxon rank sum tests to compare groups.  Gender identities self-reported as male, fluid/both or nonbinary  were pooled into the GD category.

Results

Within the MAPP, 7.6% (n=12) of PCOS youth self-identified as GD compared to 1.8% (n=3) of non PCOS youth (p=0.01, chi-square). When compared to non-PCOS GD adolescents from ASC (4.4%; n=3), the difference to PCOS youth was no longer significant (p=0.56). Among MAPP patients, gender diversity was associated with higher hirsutism scores (p<0.01), but not higher androgen levels. In PCOS, depression/anxiety was higher in GD vs cisgender youth (100% vs. 37.6%, p<0.01 and 77.8% vs. 35.8%, p=0.03 respectively).

Conclusions

Gender diversity was observed more commonly in those meeting PCOS criteria. PCOS GD youth were more hirsute and reported more depression/anxiety. Routine screening for differences in gender identity in comprehensive adolescent PCOS programs could benefit these patients, as alternate treatment approaches may be desired to support a transmasculine identity.


Corresponding author: Tania S. Burgert, MD, Division of Endocrinology, Children’s Mercy Hospital and Clinics, 3101 Broadway Blvd, Kansas City, MO 64111, USA, E-mail:

Funding source: Canadian Institutes of Health Research

Award Identifier / Grant number: 171268

  1. Research funding: This study was funded by Canadian Institutes of Health Research (No. 171268).

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: This study was a secondary analysis of data collection with waived consent.

  5. Ethical approval: The local Institutional Review Board deemed the study exempt from review.

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Received: 2022-05-07
Accepted: 2022-09-05
Published Online: 2022-10-05
Published in Print: 2022-11-25

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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