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Licensed Unlicensed Requires Authentication Published by De Gruyter June 21, 2011

Italian pediatric data support hypothesis that simultaneous epidemics of type 1 diabetes and type 2 diabetes/metabolic syndrome/obesity are polar opposite responses (i.e., symptoms) to a primary inflammatory condition

John B. Classen

Abstract

We previously postulated that iatrogenic inflammation caused epidemics of type 2 diabetes/metabolic syndrome/obesity by activating an immune suppressive cortisol response which protects against type 1 diabetes and other autoimmune diseases. In the current study, data on the incidence of obesity in different Italian provinces was compared with the incidence of type 1 diabetes in the same region. The association between obesity and type 1 diabetes was analyzed using Wilcoxon rank analysis. Results showed an inverse relationship; the regions with the highest rate of obesity (Campania and Lazia) were associated with a protective effect against type 1 diabetes. However, regions with the lowest rates of obesity were associated with the highest rate of type 1 diabetes. These results are consistent with previous analysis across different racial groups; races with high cortisol activity had an increased rate of type 2 diabetes but were protected from type 1 diabetes.


Corresponding author: John B. Classen, Classen Immunotherapies, Inc., 6517 Montrose Avenue, Baltimore, MD 21212, USA Phone: +1-410-377-8526

Published Online: 2011-06-21
Published in Print: 2011-08-01

©2011 by Walter de Gruyter Berlin Boston

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