Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter March 16, 2011

Association study in Taiwanese girls with precocious puberty

  • I-Ching Chou , Chung-Hsing Wang , Wei-De Lin , Chang-Hai Tsai and Fuu-Jen Tsai EMAIL logo
From the journal


Background: The timing of puberty has a genetic component. Recently, genome-wide association studies have identified that rs314280 on 6q21 (near the LIN28B gene) and rs2090409 on 9q31.2 (in an intergenic region) are associated with age at menarche. In this study, we aimed to determine whether the two loci were associated with the timing of puberty in Taiwanese girls.

Results: A total of 117 girls were divided into two groups: 1) precocious puberty (n=50) and 2) normal control subjects (n=45). The genotype proportions and allele frequencies in both groups were not significantly different.

Conclusion: These data suggest that rs314280 and rs2090409 polymorphisms are not a useful marker for prediction of the susceptibility of precocious puberty.

Corresponding author: Fuu-Jen Tsai, Department of Pediatrics, Children’s Medical Center, and Department of Medical Genetics, China Medical University Hospital, No. 2, Yuh-Der Road, North District, Taichung, Taiwan Phone: +886-4-22052121 ext. 2066, Fax: +886-4-22032798

Published Online: 2011-03-16
Published in Print: 2011-03-01

©2011 by Walter de Gruyter Berlin New York

Downloaded on 1.4.2023 from
Scroll to top button