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Licensed Unlicensed Requires Authentication Published by De Gruyter March 16, 2011

Hyperphosphatemic tumoral calcinosis: a 10-year follow-up

Crésio Alves EMAIL logo and Renata Lima
From the journal

Abstract

Objective: To report a case of primary hyperphosphatemic tumoral calcinosis (TC) and its long-term 10-year follow-up.

Patient: The patient was an 18-year-old male, who had been diagnosed with TC at the age of 8 years. In spite of nine surgeries for tumoral resection and medical treatments (i.e., aluminum hydroxide, non-steroidal anti-inflammatory agents) the lesions continued to progress. Physical examination showed calcified masses on shoulders, hip, elbows and right foot. PTH, calcitonin, 25(OH) vitamin D, 1,25(OH)2 vitamin D, renal and liver function, electrolytes, alkaline phosphatase, calcium and magnesium were normal. Serum phosphorus was elevated. FGF-23 (C-terminal): 1960 RU/mL (<180) Radiological and histological studies were compatible with TC.

Conclusion: This long-term follow-up illustrates the morbidity and difficulty in treating these patients due to the progressive and recurrent nature of the calcified masses, for which there is no effective treatment as yet. The discovery of FGF-23 as the factor responsible for the hyperphosphatemic type of TC paves the way for forthcoming therapies.


Corresponding author: Crésio Alves, MD, PhD, Pediatric Endocrinology Unit, Faculty of Medicine, Federal University of Bahia, Rua Plinio Moscoso, 222/601 Salvador, CEP 40157-190, Bahia, Brazil Phone: +55 (71) 9178-4055, Fax: +55 (71) 3393-1021

Published Online: 2011-03-16
Published in Print: 2011-03-01

©2011 by Walter de Gruyter Berlin New York

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