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Licensed Unlicensed Requires Authentication Published by De Gruyter March 16, 2011

Vitamin D deficiency and insulin resistance in obese African- American adolescents

  • Gail Nunlee-Bland , Kanwal Gambhir , Cynthia Abrams , Mustapha Abdul , Marjan Vahedi and Wolali Odonkor


Objective: The study aim determined if low 25-hydroxy vitamin D levels correlated with low levels of adiponectin and insulin resistance in African American adolescents with body mass index ≥85th%.

Patients and methods: Fasting blood levels of adiponectin, 25-hydroxy vitamin D, insulin, glucose, lipid, leptin and glycosylated hemoglobin were measured in a total of 34 (19 study and 15 control) African American adolescents between the ages of 10 and 20 years. Nutritional vitamin D intake and body composition measurements were assessed. Insulin resistance was calculated using the homeostasis model assessment.

Results: Adiponectin, fasting insulin, glucose, leptin, triglycerides, HDL, and 25-hydroxy vitamin D levels all reached statistical significance in the group with body mass index ≥85th percentile when compared to the control population. There was no difference in vitamin D intake between the two groups.

Conclusions: Low vitamin D levels correlated with low adiponectin levels and obesity and insulin resistance.

Corresponding author: Gail Nunlee-Bland, Howard University Hospital, 2041 Georgia Avenue NW, Washington, DC 20060, USA Phone: +202-865-3350, Fax: +202-865-3495

Published Online: 2011-03-16
Published in Print: 2011-03-01

©2011 by Walter de Gruyter Berlin New York

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