Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter March 16, 2011

The frequency of Hashimoto thyroiditis in children and the relationship between urinary iodine level and Hashimoto thyroiditis

  • Murat Doğan EMAIL logo , Emel Acikgoz , Mehmet Acikgoz , Yasar Cesur , Sevil Ariyuca and Mehmet Selcuk Bektas
From the journal


The aim of this study was to determine the frequency of thyroid autoimmunity in second grade primary school students and to examine the relationship between iodine and Hashimoto thyroiditis (HT). This was a cohort study performed with 1000 students. Urinary iodine levels, antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-Tg) antibodies were determined in all children. Children with anti-TPO or anti-Tg antibody positivity or with goiter were summoned for detailed examinations. In total, 36 cases (3.6%) were diagnosed as HT. The goiter frequency was found in 17.5% of the whole cohort. Additionally, iodine deficiency was found in 64.2% of all children. The median urinary iodine excretion was determined as 132 μg/L (range 382 μg/L) in the HT group, whereas it was 73 μg/L (range 390 μg/L) in children with goiter but without HT and 81 μg/L (range 394 μg/L) in normal children. The urinary iodine level of HT cases was significantly higher than the other two groups (p<0.001). HT was also determined in 2% of patients with low urinary iodine levels, in 6.2% of patients with normal urinary iodine levels, and in 7.5% of patients with high urinary iodine levels. Our data demonstrates the close relationship between excessive iodine levels and autoimmunity.

Corresponding author: Murat Doğan, MD, Department of Pediatrics, Division of Pediatric Endocrinology, School of Medicine, Yuzuncu Yil University, 65100 Van, Turkey Phone: + 90 506 587 1817, Fax: + 90 432 215 5281

Published Online: 2011-03-16
Published in Print: 2011-03-01

©2011 by Walter de Gruyter Berlin New York

Downloaded on 1.4.2023 from
Scroll to top button