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Licensed Unlicensed Requires Authentication Published by De Gruyter March 16, 2011

The relationship between serum phosphate levels with childhood obesity and insulin resistance

  • Nurullah Çelik EMAIL logo and Nesibe Andıran
From the journal


Aim: To investigate the relationship between serum phosphate levels with obesity and insulin resistance in childhood.

Methods: A total of 298 children and adolescents (190 obese subjects and 108 controls) were included in the study. Serum glucose, insulin, phosphate, calcium and alkaline phosphatase levels were measured after 12 h fasting at 08:00–08:30 h. We assessed insulin sensitivity by using the HOMA-IR (homeostasis model of insulin resistance) index as a surrogate marker of insulin resistance.

Results: Serum levels of phosphate were significantly lower in the 6- to 12-year-old obese subjects than controls (p=0.02, p<0.05). At the same time, there was a moderate negative correlation between serum phosphate levels and the HOMA-IR index in the 6- to 12-year-old IR (–) obese children (r=–0.26, p=0.02).

Conclusions: Low serum phosphate levels could contribute to the development of insulin resistance in 6- to 12-year-old obese children.

Corresponding author: Nurullah Çelik, Division of Endocrinology, Department of Pediatrics, Faculty of Medicine, Fatih University, Alparslan Türkeş Cad. No: 57, 06510 Emek, Ankara, Turkey Phone: +312 2035075, Fax: +312 2213670

Published Online: 2011-03-16
Published in Print: 2011-03-01

©2011 by Walter de Gruyter Berlin New York

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