Accessible Requires Authentication Published by De Gruyter September 14, 2012

Clinical evaluation of soluble intercellular adhesion molecule-1 and insulin like growth factor-binding protein-1-based rapid immunoassays for the diagnosis of prelabor rupture of membranes

Tao Wang, Rong Zhou, Wei Xiong, Yanyun Wang, Cairong Zhu, Changping Song, Linbo Gao, Lin Zhang and Huaizhong Hu

Abstract

Aims: To evaluate the clinical value of two rapid tests, based on soluble intercellular adhesion molecule-1 (Leakection) and insulinlike growth factor-binding protein-1 (Amnioquick), for the diagnosis of prelabor rupture of membranes.

Methods: A total of 200 pregnant women were recruited in this study: 100 pregnant women with membrane rupture and 100 healthy pregnant women as controls. Patients and controls were randomly divided into Leakection and Amnioquick groups, respectively. Sensitivity and specificity were calculated on the basis of the detection results.

Results: For the 100 women tested with Leakection, the sensitivity and specificity was 94% and 96%, respectively; the total accuracy was 95%. For the 100 women tested with Amnioquick, the sensitivity and specificity was 80% and 100%, respectively; the total accuracy was 90%.

Conclusions: Both Leakection and Amnioquick are non-invasive and inexpensive rapid tests for the diagnosis of premature or prelabor rupture of membranes with high sensitivity and specificity. These tests could greatly help the timely diagnosis of premature or prelabor rupture of membranes in clinical practice.


Corresponding author: Huaizhong Hu, PhD, Laboratory of Molecular and Translational Medicine, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, 20 Ren Min Nan Lu, Chengdu, Sichuan 610041, China, Tel.: 86-28-8550-3604

Received: 2012-5-30
Revised: 2012-7-6
Accepted: 2012-7-30
Published Online: 2012-09-14
Published in Print: 2013-03-01

©2013 by Walter de Gruyter Berlin Boston