Accessible Requires Authentication Published by De Gruyter December 13, 2013

Placental chorioangioma: literature review

Miaoying Fan and Daniel W. Skupski


Placental chorioangioma is the most common benign non-trophoblastic tumor of the placenta. It is derived from primitive chorionic mesenchyme and is typically vascular. Placenta chorioangiomas occur in approximately 1% of pregnancies. Most placental chorioangiomas are small and are not clinically important. However, those measuring more than 4–5 cm in diameter may be associated with maternal and fetal complications. Early diagnosis, close prenatal surveillance and appropriate intervention may prevent severe complications and perinatal mortality caused by chorioangioma. Here we review the incidence, prenatal diagnosis, complications, the pathophysiological mechanisms of maternal and fetal complications, and the therapeutic possibilities in pregnancies complicated by placental chorioangiomas.

Corresponding author: Miaoying Fan, MD, RDMS, Department of Obstetrics and Gynecology, Columbia University Medical Center, PH12-15, 622W, 168th Street, New York, NY 11355, USA, Tel.: +1-212-305-0911, Fax: +1-212-342-5337, E-mail:


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The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2013-7-11
Accepted: 2013-11-18
Published Online: 2013-12-13
Published in Print: 2014-5-1

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