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Licensed Unlicensed Requires Authentication Published by De Gruyter August 7, 2015

Adipokine, adropin and endothelin-1 levels in intrauterine growth restricted neonates and their mothers

  • Halil Ibrahim Aydin , Ayla Eser EMAIL logo , Ikbal Kaygusuz , Sevgi Yildirim , Tugrul Celik , Suzan Gunduz and Suleyman Kalman


Intrauterine growth retardation/restriction (IUGR) is associated with fetal malnutrition. It has consequences for later life including increased incidence of obesity, diabetes mellitus, cardiovascular disease (CVD), and metabolic syndrome. Adipokines (adiponectin and leptin), adropin, and endothelin-1 are associated with obesity and metabolic syndrome regulation. Intrauterine changes in these mediators could affect programming of later adult obesity and metabolic syndrome. Our objectives were to compare the levels of these mediators in both cord and maternal blood between IUGR pregnancies and control, healthy pregnancies, and to study the correlation of adipokines with adropin and endothelin-1 in maternal and cord blood in IUGR pregnancies as well as in healthy control pregnancies. Maternal and cord blood samples were taken from 16 women with IUGR pregnancies and 16 women with healthy pregnancies. Serum levels of leptin, adiponectin, adropin, and endothelin-1 were measured by ELISA. Maternal blood adropin levels were significantly lower in the IUGR group than in the control group; the other mediators did not differ significantly. There was a positive correlation between maternal blood adropin and endothelin levels. (r=0.731, P=0.001) in the control but not the IUGR group. Cord blood adropin and adiponectin levels were significantly lower in the IUGR group compared with the control group, while leptin or endothelin-1 did not differ significantly. There was a negative correlation between adropin and leptin (r=–0.704, P=0.001) in the IUGR but not the control group cord blood. There were also positive correlations between endothelin and adropin for both groups (r=0.594, P=0.006; r=0.560, P=0.010, respectively); to the best of our knowledge, this is the first report of such a correlation. Differences in fetal expression of adropin and adiponectin in IUGR could influence programming of obesity, metabolic syndrome, diabetes, and CVD in later life.

Corresponding author: Ayla Eser, MD, Assistant Professor of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Medical School, Turgut Ozal University, Hosdere Cad. No: 145-147 Y.Ayranci, Ankara, Turkey, Tel.: +00 90 312 409 88 88, +0505 319 02 57, Fax: +00 90 312 409 88 00, E-mail:


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The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2014-11-16
Accepted: 2015-7-9
Published Online: 2015-8-7
Published in Print: 2016-8-1

©2016 Walter de Gruyter GmbH, Berlin/Boston

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