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Early onset preeclampsia is associated with an elevated mean platelet volume (MPV) and a greater rise in MPV from time of booking compared with pregnant controls: results of the CAPE study

  • Cathy Monteith ORCID logo EMAIL logo , Karl Egan , Hugh O’Connor , Patricia Maguire , Barry Kevane , Paulina B. Szklanna , Sharon Cooley , Fergal Malone and Fionnuala Ní Áinle



To characterise Mean platelet volume (MPV) in patients with early onset preeclampsia (EOPE) and unaffected controls from time of first antenatal visit until the postpartum.

Materials and methods:

Retrospective secondary analysis of an observational study in an Irish tertiary referral centre with 9000 deliveries annually. The MPV of 27 women with EOPE was compared to 19 unaffected controls. The inclusion criteria for the disease state was the development of EOPE defined by the National Institute for Health and Care Excellence (NICE) guideline, as new onset hypertension presenting after 20 weeks and prior to 34 weeks with significant proteinuria. Between October 2013 and July 2015 we recruited 27 women with EOPE and 19 pregnant controls. Statistical analysis was performed using paired T-test of Mann-Whitney test where appropriate and a P-value <0.05 was deemed significant.


At time of diagnosis and late in the third trimester MPV was significantly increased to 9.0 (±0.3) fL in cases of EOPE in comparison to 8.5 (±0.6) fL in normotensive controls (P<0.05). There was no significant difference during the first trimester or postpartum when comparing the MPV in EOPE to controls.


Despite an increased MPV at time of diagnosis of EOPE this study did not demonstrate a potential use for increased MPV as a first trimester screening tool.

Corresponding author: Dr. Cathy Monteith, Clinical Lecturer and Tutor, Department of Obstetrics and Gynaecology, Royal College of Surgeons in Ireland, Rotunda Hospital, Dublin, Ireland, Tel.: 00353 14022520, Fax: 00353 14022543


This study received seed funding from the Rotunda Foundation, Dublin Ireland a registered charity (CHY20091). Following an external international peer review process the CAPE study received the prestigious Health research award of €327,000 (Grant identifier HRA POR-2013-377) to complete the study. The funders of this study were in no way involved in the writing process. We would like to thank our patients, medical colleagues, midwifery staff and laboratory technicians who provided assistance that greatly assisted the research.

  1. Author’s statement

  2. Conflict of interest: Authors state no conflict of interest.

  3. Material and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.

  4. Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.

  5. Disclosure of interest: The authors report no conflict of interest and full disclosure of interests are available to view online as supporting information.

  6. Contribution to authorship: We can confirm that all the authors have made substantive intellectual contributions to the paper; they understand their role in taking responsibility and being accountable for the publication. CM gathered the results, analysed the data and wrote the paper. KE analysed the data, performed statistical analysis and reviewed the paper. HOC recruited all patients, assisted with data collection and reviewed the paper. BK and PBS assisted in the management of the study and reviewed the paper. PM, SC, FM and FNA conceptualised the work and reviewed the paper.


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Received: 2017-06-08
Accepted: 2017-11-07
Published Online: 2017-12-21
Published in Print: 2018-11-27

©2018 Walter de Gruyter GmbH, Berlin/Boston

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