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Licensed Unlicensed Requires Authentication Published by De Gruyter May 15, 2019

Effect of gender on growth-restricted fetuses born preterm

  • Tea Štimac , Ana-Maria Šopić-Rahelić , Jelena Ivandić , Eduard Ekinja and Isaac Blickstein EMAIL logo



To assess the effect of fetal gender in small-for-gestational age (SGA) neonates with birth weight less than the fifth percentile by gestational age.


We compared male and female SGA neonates for maternal and neonatal outcomes in the following gestational age subgroups: at <32 + 6, 33 + 0–36 + 6 and at ≥37 + 0 weeks of gestation.


We examined 159, 154 and 2363 SGA neonates born at <32 + 6, 33 + 0 to 36 + 6 and ≥37 weeks of pregnancy, respectively, whose birth weight was below the fifth percentile for gestational age and who met our inclusion criteria. Overall, there were no significant differences between the mothers of males and females, except that there were more males at term and the incidence of nulliparas was greater among the mothers of males. In terms of outcomes, males had a similar incidence of respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH) and admissions to intensive care. Interestingly, low Apgar scores were more common in preterm females born at 33–37 weeks and vice versa in births over 37 weeks.


Our data do not support an advantage of either gender in preterm birth of infants who are most likely growth restricted.

Corresponding author: Isaac Blickstein, MD, Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Affiliated with the Hadassah-Hebrew University School of Medicine, 76100 Rehovot, Jerusalem, Israel, Tel.: +972-545-201789, Fax: +972-89411944

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


1. Ingemarsson I. Gender aspects of preterm births. Br J Obstect Gynaecol 2003;110:34–8.10.1046/j.1471-0528.2003.00022.xSearch in Google Scholar

2. Zisk JL, Genen LH, Kirkby S, Webb D, Greenspan J, Dysart K. Do premature female infants really do better than their male counterparts? Am J Perinatol 2011;28:241–6.10.1055/s-0030-1268239Search in Google Scholar PubMed

3. Challis J, Newnham J, Petraglia F, Yeganegi M, Bocking A. Fetal sex and preterm birth. Placenta 2013;34:95–9.10.1016/j.placenta.2012.11.007Search in Google Scholar PubMed

4. Peelen MJ, Kazemier BM, Ravelli AC, De Groot CJ, Van Der Post JA, Mol BW, et al. Impact of fetal gender on the risk of preterm birth, a national cohort study. Acta Obstet Gynecol Scand 2016;95:1034–41.10.1111/aogs.12929Search in Google Scholar PubMed

5. Teoh PJ, Ridout A, Seed P, Tribe RM, Shennan AH. Gender and preterm birth: is male fetal gender a clinically important risk factor for preterm birth in high-risk women? Eur J Obstet Gynecol Reprod Biol 2018;225:155–9.10.1016/j.ejogrb.2018.04.025Search in Google Scholar PubMed

6. O’Driscoll DN, McGovern M, Greene CM, Molloy EJ. Gender disparities in preterm neonatal outcomes. Acta Paediatr 2018;107:1494–9.10.1111/apa.14390Search in Google Scholar PubMed

7. Drazancic A, Pevec-Stupar R, Kern J. Fetal growth in Zagreb. Jugosl Ginekol Perinatol 1988;28:13–20.Search in Google Scholar

8. McIntire DD, Bloom SL, Casey BM, Leveno KJ. Birth weight in relation to morbidity and mortality among new born infants. N Engl J Med 1999;340:1234–8.10.1056/NEJM199904223401603Search in Google Scholar PubMed

Received: 2019-03-03
Accepted: 2019-04-10
Published Online: 2019-05-15
Published in Print: 2019-08-27

©2019 Walter de Gruyter GmbH, Berlin/Boston

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