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Licensed Unlicensed Requires Authentication Published by De Gruyter January 11, 2020

Variations in long-term outcome reporting among offspring followed up after lifestyle interventions in pregnancy: a systematic review

Rocío Olmedo-Requena, Carmen Amezcua-Prieto, Bassel H. Al Wattar ORCID logo, Ewelina Rogozinska, Aurora Bueno-Cavanillas, José Juan Jiménez-Moleón, Shakila Thangaratinam and Khalid S. Khan

Abstract

Background

Mothers and their offspring may benefit from lifestyle interventions during pregnancy. We systematically reviewed the literature to map and evaluate the quality of long-term offspring outcomes in follow-up cohorts of randomised controlled trials (RCTs).

Methods

We searched MEDLINE, EMBASE, CINAHL, Database of Abstracts of Reviews of Effects and Cochrane Central (until March 2019) for all RCTs evaluating any lifestyle (diet or exercise) intervention during pregnancy and their follow-up cohorts. Two reviews evaluated the extracted outcomes using two standardised assessment tools, one for quality of reporting (score range 0–6) and another for the variation in outcome selection. We extracted data in duplicate and reported using natural frequencies, medians, ranges, means and standard deviation (SD).

Results

We captured 30 long-term offspring outcomes reported in six articles (four studies). Offspring anthropometric measurements were the most commonly reported outcomes. There was a large variation in the measurement tools used. The mean overall quality score for outcome reporting was 3.33 (SD 1.24), with poor reporting of secondary outcomes and limited justification for the choice of the reported outcomes. Most studies showed selective reporting for both their primary and secondary outcomes.

Conclusion

The quality of reporting for long-term offspring outcomes following lifestyle interventions in pregnancy is varied with evidence of selective outcome reporting. Developing a core outcome set will help to reduce the variations in outcome reporting to optimise future research.


Corresponding author: Dr. Bassel H. Al Wattar, Women’s Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University, London E1 2DD, UK

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jpm-2019-0302).

Received: 2019-08-08
Accepted: 2019-11-21
Published Online: 2020-01-11
Published in Print: 2020-02-25

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