Accessible Requires Authentication Published by De Gruyter August 31, 2020

Serum kallistatin level is decreased in women with preeclampsia

Onur Güralp, Nevin Tüten, Koray Gök, Kübra Hamzaoglu, Huri Bulut, Meike Schild-Suhren, Eduard Malik and Abdullah Tüten



To evaluate the serum levels of the serine proteinase inhibitor kallistatin in women with preeclampsia (PE).


The clinical and laboratory parameters of 55 consecutive women with early-onset PE (EOPE) and 55 consecutive women with late-onset PE (LOPE) were compared with 110 consecutive gestational age (GA)-matched (±1 week) pregnant women with an uncomplicated pregnancy and an appropriate for gestational age fetus.


Mean serum kallistatin was significantly lower in women with PE compared to the GA-matched-controls (27.74±8.29 ng/mL vs. 37.86±20.64 ng/mL, p<0.001); in women with EOPE compared to that of women in the control group GA-matched for EOPE (24.85±6.65 ng/mL vs. 33.37±17.46 ng/mL, p=0.002); and in women with LOPE compared to that of women in the control group GA-matched for LOPE (30.87±8.81 ng/mL vs. 42.25±22.67 ng/mL, p=0.002). Mean serum kallistatin was significantly lower in women with EOPE compared to LOPE (24.85±6.65 ng/mL vs. 30.87±8.81 ng/mL, p<0.001). Serum kallistatin had negative correlations with systolic and diastolic blood pressure, creatinine, and positive correlation with GA at sampling and GA at birth.


Serum kallistatin levels are decreased in preeclamptic pregnancies compared to the GA-matched-controls. This decrease was also significant in women with EOPE compared to LOPE. Serum kallistatin had negative correlation with systolic and diastolic blood pressure, creatinine and positive correlation with GA at sampling and GA at birth.

Corresponding author: Onur Güralp, MD, Senior Consultant, University Hospital of Obstetrics and Gynecology, Klinikum Oldenburg, AöR Carl von Ossietzky Oldenburg University, Rahel-Strauß-Str. 10, 26133, Oldenburg, Germany. Phone: 0049 441 403 2288, E-mail:


We would like to thank our beloved nurse Medine Eltutan from our pregnancy outpatient clinic for her kind support and dedication during the patient recruitment.

  1. Research funding: This study was financed by Istanbul Cerrahpasa University, Istanbul, Turkey, and Carl von Ossietzky University Oldenburg, University Hospital for Obstetrics and Gynecology in Klinikum Oldenburg AöR, Oldenburg, Germany.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The study protocol was approved by the Ethics Committee of Istanbul Cerrahpasa University, School of Medicine and informed consent was obtained from all women participating our study. We have complied with the World Medical Association Declaration of Helsinki regarding ethical conduct of research involving human subjects and/or animals.


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Supplementary Material

The online version of this article offers supplementary material (

Received: 2020-03-31
Accepted: 2020-07-30
Published Online: 2020-08-31
Published in Print: 2021-01-26

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