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Licensed Unlicensed Requires Authentication Published online by De Gruyter May 23, 2022

Expression pattern and clinical significance of microRNA-let-7a and IFN-gamma in placental tissue of patients with preeclampsia with severe features

Liping Wang, Xiaojie Yuan and Xuewu Zhou



Preeclampsia with severe features (PECsf) is a common disease in pregnant women. let-7a and IFN-gamma (interferon-gamma) are involved in diagnosis and prognosis of preeclampsia. This study explored effects of let-7a and IFN-gamma on PECsf patients.


The placental tissue of 21 PECsf, 19 preeclampsia without severe features (PEC), and 20 normal pregnant women were collected, and clinical data were recorded. let-7a and IFN-gamma expressions in placental tissue were detected. The correlation between let-7a/IFN-gamma expression and clinical indexes was analyzed. According to let-7a and IFN-gamma expressions, PECsf patients were assigned into Hlet-7a group (let-7a high expression group), Llet-7a group (let-7a low expression group), HIFN-gamma group (IFN-gamma high expression group) and LIFN-gamma group (IFN-gamma low expression group). The incidence of adverse prognosis was compared.


let-7a and IFN-gamma were highly expressed in placental tissue of preeclampsia patients, with significant differences between PEC and PECsf. The high expressions of let-7a and IFN-gamma were positively correlated with mean arterial pressure, lactate dehydrogenase, and 24 h urinary protein in placental tissues of PECsf patients. High let-7a and IFN-gamma expressions were correlated with adverse outcomes of PECsf.


High let-7a and IFN-gamma expressions were correlated with clinical features, and could be used as biomarkers for treatment and poor prognosis of PECsf.

Corresponding Authors: Liping Wang and Xiaojie Yuan, Department of Obstetrics and Gynecology, Daqing Longnan Hospital, Daqing, Heilongjiang, P. R. China, E-mail: (L. Wang), (X. Yuan), Phone: 19904860666
Liping Wang, Xiaojie Yuan and Xuewu Zhou contributed equally to this work.

  1. Research funding: Not applicable.

  2. Author contributions: LPW, XJY and XWZ contributed to the study concepts, study design, and definition of intellectual content; XJY contributed to the literature research; LPW contributed to the manuscript preparation; XJY and XWZ contributed to the manuscript editing and review; LPW, XJY and XWZ contributed to the experimental studies and data acquisition; LPW, XJY and XWZ contributed to the data analysis and statistical analysis. All authors read and approved the final manuscript.

  3. Competing interests: All authors declare that there is no conflict of interests in this study.

  4. Ethics approval: The experiments were authorized by the academic ethics committee of Daqing Longnan Hospital. All procedures were strictly implemented by the code of ethics. All the subjects involved were fully informed of the objective of the study and signed informed consent before sampling.

  5. Data availability: All the data generated or analyzed during this study are included in this published article.


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Received: 2021-03-24
Accepted: 2022-04-03
Published Online: 2022-05-23

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