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Licensed Unlicensed Requires Authentication Published online by De Gruyter May 13, 2022

The effect of advanced maternal age on perinatal outcomes in nulliparous pregnancies

Gülhan Elçi ORCID logo, Ayşegül Çakmak ORCID logo, Erkan Elçi ORCID logo and Sena Sayan ORCID logo

Abstract

Objectives

In the current study, we aimed to evaluate the effect of advanced maternal age on perinatal outcomes in nulliparous singleton pregnancy.

Methods

The perinatal outcome data of 11,366 patients who gave birth between 2015 and 2020 were evaluated retrospectively. Patients were subgrouped according to their age as control group (C) (20–29 years), late advanced maternal age group (30–34 years), advanced maternal age group (35–39 years), and very advanced maternal age group (≥40 years). Multinomial logistic regression analyses were performed to test the possible independent role of maternal age as a risk factor for adverse pregnancy outcomes.

Results

Statistically significant difference was observed between the control group and the other groups in terms of preterm delivery, preeclampsia, gestational diabetes mellitus (GDM), small gestational age (SGA), large gestational age (LGA), premature rupture of membranes (PROM), high birth weight (HBW), and perinatal mortality rates (p<0.05). An increased risk of the need for neonatal intensive care unit (NICU) and perinatal mortality was observed in groups over 35 years old.

Conclusions

Age poses a risk in terms of preterm delivery, preeclampsia, LGA, GDM, and HBW in the groups over 30 years of maternal age. The rates of PROM, NICU, and perinatal mortality increase in addition to those perinatal results in the groups above 35 years of maternal age.


Corresponding author: Erkan Elçi, MD, Department of Obstetrics and Gynecology, University of Health Sciences Umraniye Training and Research Hospital, Istanbul, Turkey, Adem Yavuz, Str No 01, Elmalıkent, Umraniye, Postal zip Code: 34070, Istanbul, Turkey, Phone: +90 506 484 5469, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was not required because of the retrospective nature of the study; the research involves no more than minimal risk to the subjects and the waiver will not adversely affect the rights and welfare of the subjects.

  5. Ethical approval: Ethics Committee approval was received from the local ethics committee (approval number: 11/02/2021-14).

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Received: 2021-06-17
Accepted: 2022-04-01
Published Online: 2022-05-13

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