Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter March 18, 2010

Outcomes of extremely low birth weight infants with varying doses and intervals of antenatal steroid exposure

  • Sanjay Chawla , Girija Natarajan , Sharayu Rane , Ronald Thomas , Josef Cortez and Jorge Lua
From the journal


Objective: To compare outcomes of extremely low birth weight (ELBW) infants exposed to no antenatal steroids (ANS); incomplete ANS and complete course of ANS at varying intervals prior to delivery.

Methods: A retrospective review was performed on 169 ELBW infants with ANS exposure at varied dose-intervals. The odds of mortality, intraventricular hemorrhage (IVH) and bronchopulmonary dysplasia (BPD) were compared between Group 1, infants born without ANS exposure, Group 2, infants born after one dose of ANS, Group 3, infants born after two doses of ANS given within a week, and Group 4, infants born after two doses of ANS >7 days prior to delivery.

Results: Mortality and IVH were significantly lower in Groups 3 (30% and 10%) and 4 (15% and 30%), compared to Groups 1 (56% and 69%) and 2 (56% and 38%). Increasing gestational age and exposure to complete course of ANS were significantly associated with decrease in mortality, BPD/mortality and IVH. Infants who received one dose of ANS had significantly lower incidence of severe IVH compared to infants without ANS exposure.

Conclusions: Beneficial impact of ANS on mortality and composite BPD/mortality is evident only after a complete course and persists even with its administration beyond a week from delivery.

Corresponding author: Sanjay Chawla, MD Department of Neonatology Wayne State University 3901 Beaubien Detroit MI 48201 USA

Received: 2009-8-24
Revised: 2009-12-29
Accepted: 2010-1-12
Published Online: 2010-03-18
Published Online: 2010-03-18
Published in Print: 2010-07-01

©2010 by Walter de Gruyter Berlin New York

Downloaded on 24.3.2023 from
Scroll Up Arrow