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Licensed Unlicensed Requires Authentication Published by De Gruyter August 13, 2010

Comparative analysis of insulin-like growth factor binding protein-1 (IGFBP-1), placental alpha-microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membranes in pregnancy

Shephali Tagore and Kenneth Kwek
From the journal

Abstract

Purpose: To compare insulin-like growth factor binding protein-1 (IGFBP-1) (non-phosphorylated), placental alpha-microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membrane to allow gestation-specific management.

Methods: We recruited 100 women with signs or symptoms of premature rupture of membranes (PROM), between 17 and 37 weeks at a tertiary referral center.

Results: In 100 women in whom PAMG-1 was performed, sensitivity was 92.7%, specificity was 100%, positive predictive value (PPV) was 100% and negative predictive value (NPV) was 95.2%. IGFBP-1 was performed in 94 women, the sensitivity was 87.5%, specificity was 94.4%, PPV was 92.1% and NPV was 91.1%. In 98 women in whom nitrazine test was performed, the sensitivity was 85%, specificity was 39.7%, PPV was 49.3% and NPV was 79.3%.

Conclusion: PAMG-1 was the most accurate test in diagnosing rupture of membranes and had the highest sensitivity, specificity, PPVs and NPVs.


Corresponding author: Dr. Shephali Tagore MBBS, DRCOG, MD, MRCOG Department of Maternal Fetal Medicine KK Women's and Children's Hospital 100 Bukit Timah Road Singapore 229899 Tel.: +65 81211676 Fax: +65 63941017

Received: 2010-3-1
Revised: 2010-5-19
Accepted: 2010-5-21
Published Online: 2010-08-13
Published Online: 2010-08-13
Published in Print: 2010-11-01

©2010 by Walter de Gruyter Berlin New York