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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access October 8, 2014

Isolated myeloid sarcoma of the neck and chest: differential diagnosis and therapeutic approach

Predrag Djurdjevic, Danijela Jovanovic and Darko Antic
From the journal Open Medicine

Abstract

In this article, we present the case of a 57-yearold man with cervical and mediastinal tumor mass, normal blood count as well as virusological status. Cervical tumor tissue biopsy revealed cells positive for CD34, CD13, LCA, CD33, and CD163 but negative for T-cell and B-cell markers, NK-cell markers, plasmacytic markers and anaplastic large cell lymphoma markers. These features were consistent with myeloid sarcoma of the neck with involvement of the mediastinum. We discussed differential diagnosis and therapy of isolated myeloid sarcoma and suggest that clinical presentation, cell morphology, complete immunophenotype, and specific genotypic lesions in some cases, must be evaluated.

References

[1] Pileri SA, Orayi A, Falini B: Myeloid sarcoma. In Swerdlow S,Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J,Vardiman JW (eds) WHO classification of tumours of haematopoetic and lymphoid tissues. Lyon, IARC, 2008, pp 140-141Search in Google Scholar

[2] Bakst RL, Tallman MS, Douer D, Yahalom J. How I treat extramedullary acute myeloid leukemia. Blood,2011,118(14),3785-379310.1182/blood-2011-04-347229Search in Google Scholar

[3] Klco JM, Welch JS, Nguyen TT, Hurley MY, Kreisel FH, Hassan A et al. State of the art in myeloid sarcoma. Int J Lab Hematol., 2011,33(6),555-56510.1111/j.1751-553X.2011.01361.xSearch in Google Scholar

[4] Burns A. Observation of surgical anatomy, head and neck. Edinburgh: Thomas Royce and co;1811, pp 364-366Search in Google Scholar

[5] King A. A case of chloroma. Monthly J med., 1853,17:97Search in Google Scholar

[6] Rappaport H. Tumors of the hematopoetic system. Armed Forces Inst Pathol., 1966, 241-243Search in Google Scholar

[7] Antic D, Elezovic I, Milic N, Suvajdzic N, Vidovic A, Perunicic M et al. Is there a “gold” standard treatment for patients with isolated myeloid sarcoma? Biomed Pharmacother., 2013,67(1),72-7710.1016/j.biopha.2012.10.014Search in Google Scholar

[8] Hutchinson RE, Kurec AS, Davey FR. Granulocytic sarcoma. Clin Lab Med., 1990, 10, 889-901Search in Google Scholar

[9] Paydas S, Zorludemir S, Ergin M. Granulocytic sarcoma: 32 cases and review of the literature. Leuk Lymphoma., 2006, 47(12),2527-254110.1080/10428190600967196Search in Google Scholar

[10] Antic D, Verstovsek S, Elezovic I, Grujicic D, Gotic M, Bila J et al. Spinal epidural granulocytic sarcoma in non-leukemic patient. Int J Hematol., 2009,89(1),95-9710.1007/s12185-008-0227-8Search in Google Scholar

[11] Antic D, Elezovic I, Bogdanovic A, Vukovic NS, Pavlovic A, Jovanovic MP et al. Isolated myeloid sarcoma of the gastrointestinal tract. Intern Med., 2010,49(9),853-85610.2169/internalmedicine.49.2874Search in Google Scholar

[12] Colović N, Jurišić V, Terzić T, Jevtovic D, Colović M. Alveolar granulocytic sarcoma of the mandible in a patient with HIV. Onkologie, 2011,34(1-2),55-810.1159/000317351Search in Google Scholar

[13] Audouin J, Comperat E, Le Tourneau A, Camilleri- Broët S, Adida C, Molina T et al. Myeloid sarcoma: clinical and morphologic criteria useful for diagnosis Int J Surg Pathol., 2003,11(4),271-28210.1177/106689690301100404Search in Google Scholar

[14] Alexiev BA, Wang W, Ning Y, Chumsri S, Gojo I, Rodgers WH et al. Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study. Diagn Pathol., 2007, 2:4210.1186/1746-1596-2-42Search in Google Scholar

[15] Meis JM, Butler JJ, Osborne BM, Manning JT. Granulocytic sarcoma in nonleukemic patients. Cancer, 1986,58(12),2697-270910.1002/1097-0142(19861215)58:12<2697::AID-CNCR2820581225>3.0.CO;2-RSearch in Google Scholar

[16] Byrd, J.C., Edenfield, W.J., Shields, D.J. and Dawson, N.A. Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: A Clinical Review J. Clin. Oncol.,1995, 13(7), 1800-181610.1200/JCO.1995.13.7.1800Search in Google Scholar

[17] Majhi U, Murhekar K, Sundersingh S. Primary myeloid sarcoma with megakaryocytic differentiation in lymph nodes and skin. Indian J Pathol Microbiol., 2011,54(3),660-110.4103/0377-4929.85146Search in Google Scholar

[18] Elyamany G, Khan M, El Hag I, El-Zimaity M, Albalawi M, Al Abdulaaly A. Generalized Lymphadenopathy as the First Presentation of Granulocytic Sarcoma: A Diagnostic Challenge. Case Rep Med., 2013,2013,48329110.1155/2013/483291Search in Google Scholar

[19] Kojima M, Nakamura S, Shimizu K, Yamane Y, Itoh H, Masawa N. Granulocytic sarcoma presenting with lymph node infarction at disease onset. APMIS, 2003,111(12),1133-610.1111/j.1600-0463.2003.apm1111209.xSearch in Google Scholar

[20] Breccia M, Mandelli F, Petti MC, D’Andrea M, Pescarmona E, Pileri SA et al. Clinicopathological characteristics of myeloid sarcoma at diagnosis and during follow-up: report of 12 cases from a single institution. Leuk Res., 2004,28(11),1165-116910.1016/j.leukres.2004.01.022Search in Google Scholar

[21] Neiman RS, Barcos M, Berard C, Bonner H, Mann R, Rydell RE et al. Granulocytic sarcoma: a clinicopathologic study of 61 biopsed cases. Cancer 1981,48, 1426-143710.1002/1097-0142(19810915)48:6<1426::AID-CNCR2820480626>3.0.CO;2-GSearch in Google Scholar

[22] Yamauchi K, Yasuda M. Comparison in treatments of nonleukemic granulocytic sarcoma: report of two cases and a review of 72 cases in the literature. Cancer. 2002,94(6),1739-174610.1002/cncr.10399Search in Google Scholar

[23] Tsimberidou AM, Kantarjian HM, Wen S, Keating MJ, O’Brien S, Brandt M et al. Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia. Cancer. 2008,113(6),1370-137810.1002/cncr.23691Search in Google Scholar

[24] Pileri SA Ascani S, Cox MC, Campidelli C, Bacci F, Piccioli M et al. Myeloid sarcoma: clinico pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia. 2007, 21(2),340-35010.1038/sj.leu.2404491Search in Google Scholar

[25] Lan TY, Lin DT, Tien HF, Yang RS, Chen CY, Wu K. Prognostic factors of treatment outcomes in patients with granulocytic sarcoma. Acta Haematol.,2009,122(4),238-24610.1159/000253592Search in Google Scholar

[26] Chevallier P, Labopin M, Cornelissen J, Socié G, Rocha V, Mohty M; ALWP of EBMT. Allogeneic hematopoietic stem cell transplantation for isolated and leukemic myeloid sarcoma in adults: a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation. Haemat ologica,2011,96(9),1391-139410.3324/haematol.2011.041418Search in Google Scholar PubMed PubMed Central

[27] Antic D, Milic N. systemic versus localized therapeutic approach for isolated myeloid sarcoma: meta-analysis of individual patient data. Haematologica, 2013, 98(s1),281. abstract n. 0667Search in Google Scholar

Received: 2013-10-8
Accepted: 2014-6-4
Published Online: 2014-10-8
Published in Print: 2015-1-1

© 2015 Predrag Djurdjevic, Danijela Jovanovic, Darko Antic

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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