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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access July 7, 2015

Formaldehyde may be found in cosmetic products even when unlabelled

Laura Malinauskiene , Audra Blaziene , Anzelika Chomiciene and Marléne Isaksson
From the journal Open Medicine

Abstract

Concomitant contact allergy to formaldehyde and formaldehyde-releasers remains common among patients with allergic contact dermatitis. Concentration of free formaldehyde in cosmetic products within allowed limits have been shown to induce dermatitis from shortterm use on normal skin.

The aim of this study was to investigate the formaldehyde content of cosmetic products made in Lithuania. 42 samples were analysed with the chromotropic acid (CA) method for semi-quantitative formaldehyde determination. These included 24 leave-on (e.g., creams, lotions) and 18 rinse-off (e.g., shampoos, soaps) products. Formaldehyde releasers were declared on the labels of 10 products. No formaldehyde releaser was declared on the label of the only face cream investigated, but levels of free formaldehyde with the CA method was >40 mg/ml and when analysed with a high-performance liquid chromatographic method – 532 ppm. According to the EU Cosmetic directive, if the concentration of formaldehyde is above 0.05% a cosmetic product must be labelled “contains formaldehyde“. It could be difficult for patients allergic to formaldehyde to avoid contact with products containing it as its presence cannot be determined from the ingredient labelling with certainty. The CA method is a simple and reliable method for detecting formaldehyde presence in cosmetic products.

References

[1] de Groot A.C., Flyvholm M.A., Lensen G., Menné T., Coenraads P.J., Formaldehyde-releasers: relationship to formaldehyde contact allergy. Contact allergy to formaldehyde and inventory of formaldehyde-releasers, Contact Dermatitis, 2009, 61, 63–85 10.1111/j.1600-0536.2009.01582.xSearch in Google Scholar

[2] Johansen Duus J., Frosch P.J., Lepoittevin J.-P., Contact Dermatitis, 5th ed., Springer, Berlin, 2011 10.1007/978-3-642-03827-3Search in Google Scholar

[3] Fregert S., Dahlquist I., Gruvberger B., A simple method for the detection of formaldehyde, Contact Dermatitis, 1984, 10, 132–134 10.1111/j.1600-0536.1984.tb00017.xSearch in Google Scholar

[4] Benassi C.A., Semenzato A., Bettero A., High-performance liquid chromatographic determination of free formaldehyde in cosmetics, J Chromatogr, 1989, 464, 387–393 10.1016/S0021-9673(00)94256-0Search in Google Scholar

[5] Blohm G., Formaldehyde contact dermatitis, Acta Derm Venereol, 1959, 39, 450–453 Search in Google Scholar

[6] Dahlquist I., Fregert S., Gruvberger B., Reliability of the chromotropic acid method for qualitative formaldehyde determination, Contact Dermatitis, 1980, 6, 357–358 10.1111/j.1600-0536.1980.tb04971.xSearch in Google Scholar PubMed

[7] Hamburger R., Azaz E., Donbrow M., Autoxidation of polyethylenic non-ionic surfactants and of polyethylene glycols, Pharm Acta Helv, 1975, 50, 10–17 Search in Google Scholar

[8] Rieger M.M., Peroxides in polyethylene glycols and polyethylene glycol derivatives, Cosmetics Perfumery, 1975, 90, 12–16 Search in Google Scholar

[9] Bergh M., Magnusson K., Nilsson J-L.G., Karlberg A-T., Contact allergenic activity of Tween 80 before and after air exposure, Contact Dermatitis, 1997, 37, 9–18 10.1111/j.1600-0536.1997.tb00368.xSearch in Google Scholar PubMed

[10] Goon A., Gruvberger B., Persson L., Isaksson M., Bruze M., Presence of formaldehyde in topical corticosteroid preparations available on the Swedish market, Contact Dermatitis, 2003, 48,199–203 10.1034/j.1600-0536.2003.00082.xSearch in Google Scholar PubMed

[11] Tegner E., Fregert F., Contamination of cosmetics with formaldehyde from tubes, Contact Dermatitis Newsletter, 1973, 13, 353 Search in Google Scholar

[12] Fregert S. Contamination of chemico-technical preparations with formaldehyde from packages, Contact Dermatitis, 1977, 3,109–110 10.1111/j.1600-0536.1977.tb03621.xSearch in Google Scholar PubMed

[13] de Groot A.C., White I., Flyvholm M.A., et al., Formaldehydereleasers in cosmetics: relationship to formaldehyde contact allergy. Part 1. Characterization, frequency and relevance of sensitization, and frequency of use in cosmetics. Contact Dermatitis, 2010, 62, 2-17 10.1111/j.1600-0536.2009.01615.xSearch in Google Scholar PubMed

[14] Gruvberger B., Bruze M., Tammela M., Preservatives in moisturizers on the Swedish market, Acta Derm Venereol, 1998, 78, 52-56 10.1080/00015559850135850Search in Google Scholar PubMed

[15] Rastogi S.C., A survey of formaldehyde in shampoos and skin creams on the Danish market, Contact Dermatitis 1992, 27, 235-240 10.1111/j.1600-0536.1992.tb03252.xSearch in Google Scholar PubMed

[16] Hauksson I., Pontén A., Isaksson M., et al., Formaldehyde in skin care products and cosmetics in dermatitis patients, Contact Dermatitis, 2012, 66, 47 Search in Google Scholar

[17] Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products, Off J Eur Union, 2009, L342, 59-209 Search in Google Scholar

[18] Hauksson I., Ponten A., Gruvberger B., et al., Skin care products containing low concentrations of formaldehyde detected by the chromotropic acid method cannot be safely used in formaldehyde-allergic individuals with irritant contact dermatitis. Submitted Search in Google Scholar

[19] Flyvholm M.A., Hall B.M., Agner T., Tiedemann E., Greenhill P., Vanderweken W., Freeberg F.E., Menné T., Threshold for occluded formaldehyde patch test in formaldehyde-sensitive patients, Contact Dermatitis, 1997, 36, 26–33 10.1111/j.1600-0536.1997.tb00918.xSearch in Google Scholar PubMed

[20] Bergh M., Magnusson K., Nilsson J.L., et al., Formation of formaldehyde and peroxides by air oxidation of high puritypolyoxyethylene surfactants, Contact Dermatitis, 1998, 39, 14-20 10.1111/j.1600-0536.1998.tb05805.xSearch in Google Scholar PubMed

[21] Hauksson I., Pontén A., Gruvberger B., et al., Clinically relevant contact allergy to formaldehyde may be missed by testing with formaldehyde 1.0%, Br J Dermatol, 2011, 164, 568-572 10.1111/j.1365-2133.2010.10151.xSearch in Google Scholar PubMed

[22] Shaughnessy C.N., Malajian D., Belsito D.V., Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: Reactivity to topical preservatives, J Am Acad Dermatol, 2014, 70, 102-117 10.1016/j.jaad.2013.08.046Search in Google Scholar PubMed

[23] Lundov M.D., Opstrup M.S., Johansen J.D., Methylisothiazolinone contact allergy-growing epidemic, Contact Dermatitis, 2013, 69, 271-275 10.1111/cod.12149Search in Google Scholar PubMed

[24] Warshaw E.M., Belsito D.V., Taylor J.S., Sasseville D., DeKoven J.G., Zirwas M.J., et al., North American Contact Dermatitis Group patch test results: 2009 to 2010, Dermatitis, 2013, 24, 50-59 10.1097/DER.0b013e3182819c51Search in Google Scholar PubMed

[25] Isaksson M., Hauksson I., Hindsen M., et al., Methylisothiazolinone contact allergy is rising to alarming heights also in southern Sweden, Acta Derm Venereol 2014, DOI:10.2340/00015555-1844 10.2340/00015555-1844Search in Google Scholar PubMed

[26] Gonçalo M., Goossens A., Whilst Rome burns: the epidemic of contact allergy to methylisothiazolinone, Contact Dermatitis, 2013, 68, 257-258 10.1111/cod.12098Search in Google Scholar PubMed

Received: 2015-2-2
Accepted: 2015-5-28
Published Online: 2015-7-7

© 2015 Laura Malinauskiene et al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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