Skip to content
BY 4.0 license Open Access Published by De Gruyter Open Access December 17, 2021

pH-responsive cisplatin-loaded niosomes: synthesis, characterization, cytotoxicity study and interaction analyses by simulation methodology

  • Saman Sargazi EMAIL logo , Seyedeh Maryam Hosseinikhah , Farshid Zargari , Narendra Pal Singh Chauhana , Mohadeseh Hassanisaadi and Soheil Amani
From the journal Nanofabrication

Abstract

Cisplatin (Cis) is an effective cytotoxic agent, but its administration has been challenged by kidney problems, reduced immunity system, chronic neurotoxicity, and hemorrhage. To address these issues, pH-responsive non-ionic surfactant vesicles (niosomes) by Span 60 and Tween 60 derivatized by cholesteryl hemisuccinate (CHEMS), a pH-responsive agent, and Ergosterol (helper lipid), were developed for the first time to deliver Cis. The drug was encapsulated in the niosomes with a high encapsulation efficiency of 89%. This system provided a responsive release of Cis in pH 5.4 and 7.4, thereby improving its targeted anticancer drug delivery. The noisome bilayer model was studied by molecular dynamic simulation containing Tween 60, Span 60, Ergosterol, and Cis molecules to understand the interactions between the loaded drug and noisome constituents. We found that the platinum and chlorine atoms in Cis are critical factors in distributing the drug between water and bilayer surface. Finally, the lethal effect of niosomal Cis was investigated on the MCF7 breast cancer cell line using 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Results from morphology monitoring and cytotoxic assessments suggested a better cell-killing effect for niosomal Cis than standard Cis. Together, the synthesis of stimuli-responsive niosomes could represent a promising delivery strategy for anticancer drugs.

References

[1] Kanaani L, Tabrizi MM, Khiyavi AA, Javadi IJAPJoCB. Improving the Efficacy of Cisplatin using Niosome Nanoparticles Against Human Breast Cancer Cell Line BT-20: An In Vitro Study. 2017;2(2):27-9.10.31557/apjcb.2017.2.2.27-29Search in Google Scholar

[2] Tang X, Loc WS, Dong C, Matters GL, Butler PJ, Kester M, et al. The use of nanoparticulates to treat breast cancer. Nanomedicine. 2017;12(19):2367-88.10.2217/nnm-2017-0202Search in Google Scholar PubMed PubMed Central

[3] Rahdar A, Hajinezhad MR, Hamishekar H, Ghamkhari A, Kyzas GZ. Copolymer/graphene oxide nanocomposites as potential anticancer agents. Polymer Bulletin. 2020:1-22.10.1007/s00289-020-03354-6Search in Google Scholar

[4] Alijani HQ, Iravani S, Pourseyedi S, Torkzadeh-Mahani M, Barani M, Khatami M. Biosynthesis of spinel nickel ferrite nanowhiskers and their biomedical applications. Scientific Reports. 2021;11(1):1-7.10.1038/s41598-021-96918-zSearch in Google Scholar PubMed PubMed Central

[5] Amiri MS, Mohammadzadeh V, Yazdi MET, Barani M, Rahdar A, Kyzas GZ. Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review. Molecules. 2021;26(6):1770.10.3390/molecules26061770Search in Google Scholar PubMed PubMed Central

[6] Arkaban H, Ebrahimi AK, Yarahmadi A, Zarrintaj P, Barani M. Development of a multifunctional system based on CoFe2O4@ polyacrylic acid NPs conjugated to folic acid and loaded with doxorubicin for cancer theranostics. Nanotechnology. 2021;32(30):305101.10.1088/1361-6528/abf878Search in Google Scholar PubMed

[7] Barani M, Bilal M, Rahdar A, Arshad R, Kumar A, Hamishekar H, et al. Nanodiagnosis and nanotreatment of colorectal cancer: An overview. J Nanoparticle Research. 2021;23(1):1-25.10.1007/s11051-020-05129-6Search in Google Scholar

[8] Barani M, Bilal M, Sabir F, Rahdar A, Kyzas GZ. Nanotechnology in ovarian cancer: Diagnosis and treatment. Life Sciences. 2020:118914.10.1016/j.lfs.2020.118914Search in Google Scholar PubMed

[9] Barani M, Mirzaei M, Mahani MT, Nematollahi MH. Lawsone-loaded Niosome and its Antitumor Activity in MCF-7 Breast Cancer Cell Line: A Nano-herbal Treatment for Cancer. DARU J Pharm Sci. 2018;26:1-7.10.1007/s40199-018-0207-3Search in Google Scholar PubMed PubMed Central

[10] Barani M, Mirzaei M, Torkzadeh-Mahani M, Adeli-Sardou M. Evaluation of carum-loaded niosomes on breast cancer cells: Physicochemical properties, in vitro cytotoxicity, flow cytometric, DNA fragmentation and cell migration assay. Scientific reports. 2019;9(1):1-10.10.1038/s41598-019-43755-wSearch in Google Scholar PubMed PubMed Central

[11] Mashayekhi S, Rasoulpoor S, Shabani S, Esmaeilizadeh N, Serati-Nouri H, Sheervalilou R, et al. Curcumin-loaded mesoporous silica nanoparticles/nanofiber composites for supporting long-term proliferation and stemness preservation of adipose-derived stem cells. Int J Pharm. 2020;587:119656.10.1016/j.ijpharm.2020.119656Search in Google Scholar PubMed

[12] Shakeri-Zadeh A, Zareyi H, Sheervalilou R, Laurent S, Ghaznavi H, Samadian H. Gold nanoparticle-mediated bubbles in cancer nanotechnology. Journal of Controlled Release. 2020.10.1016/j.jconrel.2020.12.022Search in Google Scholar PubMed

[13] Irajirad R, Ahmadi A, Najafabad BK, Abed Z, Sheervalilou R, Khoei S, et al. Combined thermo-chemotherapy of cancer using 1 MHz ultrasound waves and a cisplatin-loaded sonosensitizing nanoplatform: an in vivo study. Cancer chemotherapy and pharmacology. 2019;84(6):1315-21.10.1007/s00280-019-03961-9Search in Google Scholar PubMed

[14] Shirvalilou S, Khoei S, Esfahani AJ, Kamali M, Shirvaliloo M, Sheervalilou R, et al. Magnetic Hyperthermia as an adjuvant cancer therapy in combination with radiotherapy versus radiotherapy alone for recurrent/progressive glioblastoma: a systematic review. J Neuro-Oncology. 2021:1-10.10.1007/s11060-021-03729-3Search in Google Scholar PubMed

[15] Dasari S, Tchounwou PBJEjop. Cisplatin in cancer therapy: molecular mechanisms of action. 2014;740:364-78.10.1016/j.ejphar.2014.07.025Search in Google Scholar PubMed PubMed Central

[16] Dhar S, Kolishetti N, Lippard SJ, Farokhzad OCJPotNAoS. Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo. 2011;108(5):1850-5.10.1073/pnas.1011379108Search in Google Scholar PubMed PubMed Central

[17] Barani M, Mirzaei M, Torkzadeh-Mahani M, Lohrasbi-Nejad A, Nematollahi MH. A new formulation of hydrophobin-coated nio-some as a drug carrier to cancer cells. Materials Sci Eng: C. 2020;113:110975.10.1016/j.msec.2020.110975Search in Google Scholar PubMed

[18] Barani M, Mukhtar M, Rahdar A, Sargazi G, Thysiadou A, Kyzas GZ. Progress in the Application of Nanoparticles and Graphene as Drug Carriers and on the Diagnosis of Brain Infections. Molecules. 2021;26(1):186.10.3390/molecules26010186Search in Google Scholar PubMed PubMed Central

[19] Barani M, Nematollahi MH, Zaboli M, Mirzaei M, Torkzadeh-Mahani M, Pardakhty A, et al. In silico and in vitro study of magnetic niosomes for gene delivery: The effect of ergosterol and cholesterol. Mat Sci Eng: C. 2019;94:234-46.10.1016/j.msec.2018.09.026Search in Google Scholar PubMed

[20] Barani M, Sabir F, Rahdar A, Arshad R, Kyzas GZ. Nanotreatment and nanodiagnosis of prostate cancer: recent updates. Nanomaterials. 2020;10(9):1696.10.3390/nano10091696Search in Google Scholar PubMed PubMed Central

[21] Chauhan NPS, Jadoun S, Rathore BS, Barani M, Zarrintaj P. Redox polymers for capacitive energy storage applications. J Energy Storage. 2021;43:103218.10.1016/j.est.2021.103218Search in Google Scholar

[22] Das SS, Bharadwaj P, Bilal M, Barani M, Rahdar A, Taboada P, et al. Stimuli-responsive polymeric nanocarriers for drug delivery, imaging, and theragnosis. Polymers. 2020;12(6):1397.10.3390/polym12061397Search in Google Scholar PubMed PubMed Central

[23] Davarpanah F, Yazdi AK, Barani M, Mirzaei M, Torkzadeh-Mahani M. Magnetic delivery of antitumor carboplatin by using PEGylated-Niosomes. DARU J Pharm Sci. 2018;26(1):57-64.10.1007/s40199-018-0215-3Search in Google Scholar PubMed PubMed Central

[24] Ebrahimi AK, Barani M, Sheikhshoaie I. Fabrication of a new superparamagnetic metal-organic framework with core-shell nanocomposite structures: Characterization, biocompatibility, and drug release study. Mat Sci Eng: C. 2018;92:349-55.10.1016/j.msec.2018.07.010Search in Google Scholar PubMed

[25] Hajizadeh MR, Maleki H, Barani M, Fahmidehkar MA, Mahmoodi M, Torkzadeh-Mahani M. In vitro cytotoxicity assay of D-limonene niosomes: an efficient nano-carrier for enhancing solubility of plant-extracted agents. Research in Pharm Sci. 2019;14(5):448.10.4103/1735-5362.268206Search in Google Scholar PubMed PubMed Central

[26] Hajizadeh MR, Parvaz N, Barani M, Khoshdel A, Fahmidehkar MA, Mahmoodi M, et al. Diosgenin-loaded niosome as an effective phytochemical nanocarrier: Physicochemical characterization, loading efficiency, and cytotoxicity assay. DARU J Pharm Sci. 2019;27(1):329-39.10.1007/s40199-019-00277-0Search in Google Scholar PubMed PubMed Central

[27] Chiani M, Milani AT, Nemati M, Rezaeidian J, Ehsanbakhsh H, Ahmadi Z, et al. Anticancer effect of cisplatin-loaded poly (Butyl-cyanoacrylate) nanoparticles on A172 brain cancer cells line. 2019;20(1):303.10.31557/APJCP.2019.20.1.303Search in Google Scholar PubMed PubMed Central

[28] Rahdar A, Hajinezhad MR, Sivasankarapillai VS, Askari F, Noura M, Kyzas GZ. Synthesis, characterization, and intraperitoneal biochemical studies of zinc oxide nanoparticles in Rattus norvegicus. Applied Physics A. 2020;126(5):1-9.10.1007/s00339-020-03535-0Search in Google Scholar

[29] Salimi A, Zadeh BSM, Godazgari S, Rahdar A. Development and Evaluation of Azelaic Acid-Loaded Microemulsion for Transfollicular Drug Delivery Through Guinea Pig Skin: A Mechanistic Study. Adv Pharm bulletin. 2020;10(2):239.10.34172/apb.2020.028Search in Google Scholar PubMed PubMed Central

[30] Sivasankarapillai V, Das S, Sabir F, Sundaramahalingam M, Colmenares J, Prasannakumar S, et al. Progress in natural polymer engineered biomaterials for transdermal drug delivery systems. Materials Today Chemistry. 2021;19:100382.10.1016/j.mtchem.2020.100382Search in Google Scholar

[31] Sivasankarapillai VS, Pillai AM, Rahdar A, Sobha AP, Das SS, Mitropoulos AC, et al. On facing the SARS-CoV-2 (COVID-19) with combination of nanomaterials and medicine: possible strategies and first challenges. Nanomaterials. 2020;10(5):852.10.3390/nano10050852Search in Google Scholar PubMed PubMed Central

[32] Taimoory SM, Rahdar A, Aliahmad M, Sadeghfar F, Hajinezhad MR, Jahantigh M, et al. The synthesis and characterization of a magnetite nanoparticle with potent antibacterial activity and low mammalian toxicity. J Molecular Liquids. 2018;265:96-104.10.1016/j.molliq.2018.05.105Search in Google Scholar

[33] Farooq MA, Aquib M, Farooq A, Haleem Khan D, Joelle Maviah MB, Sied Filli M, et al. Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview. 2019;47(1):1674-92.10.1080/21691401.2019.1604535Search in Google Scholar PubMed

[34] Hasanein P, Rahdar A, Barani M, Baino F, Yari S. Oil-in-water microemulsion encapsulation of antagonist drugs prevents renal ischemia-reperfusion injury in rats. Appl Sci. 2021;11(3):1264.10.3390/app11031264Search in Google Scholar

[35] Hosseinikhah SM, Barani M, Rahdar A, Madry H, Arshad R, Mohammadzadeh V, et al. Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis. Int J Molecular Sci. 2021;22(6):3092.10.3390/ijms22063092Search in Google Scholar PubMed PubMed Central

[36] Motamedi N, Barani M, Lohrasbi-Nejad A, Mortazavi M, Riahi-Medvar A, Varma RS, et al. Enhancement of thermostability of aspergillus flavus urate oxidase by immobilization on the Ni-based magnetic metal–organic framework. Nanomaterials. 2021;11(7):1759.10.3390/nano11071759Search in Google Scholar PubMed PubMed Central

[37] Mukhtar M, Bilal M, Rahdar A, Barani M, Arshad R, Behl T, et al. Nanomaterials for diagnosis and treatment of brain cancer: Recent updates. Chemosensors. 2020;8(4):117.10.3390/chemosensors8040117Search in Google Scholar

[38] Nikazar S, Barani M, Rahdar A, Zoghi M, Kyzas GZ. Photo-and Magnetothermally Responsive Nanomaterials for Therapy, Controlled Drug Delivery and Imaging Applications. ChemistrySelect. 2020;5(40):12590-609.10.1002/slct.202002978Search in Google Scholar

[39] Okey-Onyesolu CF, Hassanisaadi M, Bilal M, Barani M, Rahdar A, Iqbal J, et al. Nanomaterials as Nanofertilizers and Nanopesticides: An Overview. ChemistrySelect. 2021;6(33):8645-63.10.1002/slct.202102379Search in Google Scholar

[40] Qindeel M, Barani M, Rahdar A, Arshad R, Cucchiarini M. Nanomaterials for the diagnosis and treatment of urinary tract infections. Nanomaterials. 2021;11(2):546.10.3390/nano11020546Search in Google Scholar PubMed PubMed Central

[41] Rahdar A, Hajinezhad MR, Nasri S, Beyzaei H, Barani M, Trant JF. The synthesis of methotrexate-loaded F127 microemulsions and their in vivo toxicity in a rat model. J Molecular Liquids. 2020;313:113449.10.1016/j.molliq.2020.113449Search in Google Scholar

[42] Rahdar A, Taboada P, Hajinezhad MR, Barani M, Beyzaei H. Effect of tocopherol on the properties of Pluronic F127 microemulsions: Physico-chemical characterization and in vivo toxicity. J Molecular Liquids. 2019;277:624-30.10.1016/j.molliq.2018.12.074Search in Google Scholar

[43] Sabir F, Barani M, Mukhtar M, Rahdar A, Cucchiarini M, Zafar MN, et al. Nanodiagnosis and nanotreatment of cardiovascular diseases: An overview. Chemosensors. 2021;9(4):67.10.3390/chemosensors9040067Search in Google Scholar

[44] Babaei M, Akbarzade A, Arjmand M, Safekordi A. Effect Of Cisplatin Niosome And Cisplatin Niosome Polyethylenglycol On A172 Cell Line. 2014.Search in Google Scholar

[45] Ag Seleci D, Seleci M, Walter J-G, Stahl F, Scheper TJJon. Niosomes as nanoparticular drug carriers: fundamentals and recent applications. 2016.10.1155/2016/7372306Search in Google Scholar

[46] Sabir F, Qindeel M, Zeeshan M, Ul Ain Q, Rahdar A, Barani M, et al. Onco-Receptors Targeting in Lung Cancer via Application of Surface-Modified and Hybrid Nanoparticles: A Cross-Disciplinary Review. Processes. 2021;9(4):621.10.3390/pr9040621Search in Google Scholar

[47] Sabir F, Zeeshan M, Laraib U, Barani M, Rahdar A, Cucchiarini M, et al. DNA based and stimuli-responsive smart nanocarrier for diagnosis and treatment of cancer: Applications and challenges. Cancers. 2021;13(14):3396.10.3390/cancers13143396Search in Google Scholar PubMed PubMed Central

[48] Sharma V, Dash SK, Govarthanan K, Gahtori R, Negi N, Barani M, et al. Recent Advances in Cardiac Tissue Engineering for the Management of Myocardium Infarction. Cells. 2021;10(10):2538.10.3390/cells10102538Search in Google Scholar PubMed PubMed Central

[49] Torkzadeh-Mahani M, Zaboli M, Barani M, Torkzadeh-Mahani M. A combined theoretical and experimental study to improve the thermal stability of recombinant D-lactate dehydrogenase immobilized on a novel superparamagnetic Fe3O4NPs@ metal–organic framework. Applied Organometallic Chemistry. 2020;34(5):e5581.10.1002/aoc.5581Search in Google Scholar

[50] Zeraati M, Kazemzadeh P, Barani M, Sargazi G. Selecting the appropriate carbon source in the synthesis of SiC nano-powders using an optimized Fuzzy Model. Silicon. 2021:1-12.10.1007/s12633-021-01082-8Search in Google Scholar

[51] Akbari A, Sabouri Z, Hosseini HA, Hashemzadeh A, Khatami M, Darroudi M. Effect of nickel oxide nanoparticles as a photocatalyst in dyes degradation and evaluation of effective parameters in their removal from aqueous environments. Inorganic Chemistry Communications. 2020;115:107867.10.1016/j.inoche.2020.107867Search in Google Scholar

[52] Alijani HQ, Pourseyedi S, Mahani MT, Khatami M. Green synthesis of zinc sulfide (ZnS) nanoparticles using Stevia rebaudiana Bertoni and evaluation of its cytotoxic properties. J Molecular Structure. 2019;1175:214-8.10.1016/j.molstruc.2018.07.103Search in Google Scholar

[53] Alijani HQ, Pourseyedi S, Torkzadeh-Mahani M, Seifalian A, Khatami M. Bimetallic nickel-ferrite nanorod particles: greener synthesis using rosemary and its biomedical efficiency. Artificial cells, nanomedicine, and biotechnology. 2020;48(1):242-51.10.1080/21691401.2019.1699830Search in Google Scholar PubMed

[54] Alkasir M, Samadi N, Sabouri Z, Mardani Z, Khatami M, Darroudi M. Evaluation cytotoxicity effects of biosynthesized zinc oxide nanoparticles using aqueous Linum Usitatissimum extract and investigation of their photocatalytic activityackn. Inorganic Chemistry Communications. 2020;119:108066.10.1016/j.inoche.2020.108066Search in Google Scholar

[55] Das SS, Bharadwaj P, Bilal M, Barani M, Rahdar A, Taboada P, et al. Stimuli-responsive polymeric nanocarriers for drug delivery, imaging, and theragnosis. 2020;12(6):1397.10.3390/polym12061397Search in Google Scholar PubMed PubMed Central

[56] Cosco D, Paolino D, Muzzalupo R, Celia C, Citraro R, Caponio D, et al. Novel PEG-coated niosomes based on bola-surfactant as drug carriers for 5-fluorouracil. 2009;11(5):1115-25.10.1007/s10544-009-9328-2Search in Google Scholar PubMed

[57] Gude R, Jadhav M, Rao S, Jagtap AJCB, Radiopharmaceuticals. Effects of niosomal cisplatin and combination of the same with theophylline and with activated macrophages in murine B16F10 melanoma model. 2002;17(2):183-92.10.1089/108497802753773801Search in Google Scholar PubMed

[58] Yang H, Deng A, Zhang J, Wang J, Lu BJJom. Preparation, characterization and anticancer therapeutic efficacy of cisplatin-loaded niosomes. 2013;30(3):237-44.10.3109/02652048.2012.717116Search in Google Scholar PubMed

[59] Catanzaro D, Nicolosi S, Cocetta V, Salvalaio M, Pagetta A, Ragazzi E, et al. Cisplatin liposome and 6-amino nicotinamide combination to overcome drug resistance in ovarian cancer cells. Oncotarget. 2018;9(24):16847.10.18632/oncotarget.24708Search in Google Scholar PubMed PubMed Central

[60] Huo T, Barth RF, Yang W, Nakkula RJ, Koynova R, Tenchov B, et al. Preparation, biodistribution and neurotoxicity of liposomal cisplatin following convection enhanced delivery in normal and F98 glioma bearing rats. PloS one. 2012;7(11):e48752.10.1371/journal.pone.0048752Search in Google Scholar PubMed PubMed Central

[61] Haghighat M, Alijani HQ, Ghasemi M, Khosravi S, Borhani F, Sharifi F, et al. Cytotoxicity properties of plant-mediated synthesized K-doped ZnO nanostructures. Bioprocess and Biosystems Engineering. 2021:1-9.10.1007/s00449-021-02643-2Search in Google Scholar PubMed

[62] Alahri MB, Arshadizadeh R, Raeisi M, Khatami M, Sajadi MS, Abdelbasset WK, et al. Theranostic applications of metal-organic frameworks (MOFs)-based materials in brain disorders: recent advances and challenges. Inorganic Chemistry Communications. 2021:108997.10.1016/j.inoche.2021.108997Search in Google Scholar

[63] Sabouri Z, Rangrazi A, Amiri MS, Khatami M, Darroudi M. Green synthesis of nickel oxide nanoparticles using Salvia hispanica L.(chia) seeds extract and studies of their photocatalytic activity and cytotoxicity effects. Bioprocess and Biosystems Engineering. 2021;44(11):2407-15.10.1007/s00449-021-02613-8Search in Google Scholar PubMed

[64] Sargazi S, Hajinezhad MR, Barani M, Rahdar A, Shahraki S, Karimi P, et al. Synthesis, characterization, toxicity and morphology assessments of newly prepared microemulsion systems for delivery of valproic acid. Journal of Molecular Liquids. 2021;338:116625.10.1016/j.molliq.2021.116625Search in Google Scholar

[65] Barani M, Sangiovanni E, Angarano M, Rajizadeh MA, Mehrabani M, Piazza S, et al. Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature. International Journal of Nanomedicine. 2021;16:6983-7022.10.2147/IJN.S318416Search in Google Scholar PubMed PubMed Central

[66] Zarrintaj P, Ghorbani S, Barani M, Singh Chauhan NP, Khodadadi Yazdi M, Saeb MR, et al. Polylysine for Skin Regeneration: A Review of Recent Advances and Perspectives. Bioengineering & Translational Medicine.e10261.Search in Google Scholar

[67] Ouyang D, Smith SC. Introduction to computational pharmaceutics. Computational Pharmaceutics. 2015:1-5.10.1002/9781118573983.ch1Search in Google Scholar

[68] Villalobos R, V Garcia E, Quintanar D, M Young P. Drug release from inert spherical matrix systems using Monte Carlo simulations. Current drug delivery. 2017;14(1):65-72.10.2174/1567201813666160512145800Search in Google Scholar PubMed

[69] Dickson CJ, Madej BD, Skjevik ÅA, Betz RM, Teigen K, Gould IR, et al. Lipid14: the amber lipid force field. Journal of chemical theory and computation. 2014;10(2):865-79.10.1021/ct4010307Search in Google Scholar PubMed PubMed Central

[70] Vanquelef E, Simon S, Marquant G, Garcia E, Klimerak G, Delepine JC, et al. RED Server: a web service for deriving RESP and ESP charges and building force field libraries for new molecules and molecular fragments. Nucleic Acids Res. 2011;39(suppl_2):W511-W7.10.1093/nar/gkr288Search in Google Scholar PubMed PubMed Central

[71] Sousa da Silva AW, Vranken WF. ACPYPE - AnteChamber PYthon Parser interfacE. BMC Research Notes. 2012;5(1):367.10.1186/1756-0500-5-367Search in Google Scholar PubMed PubMed Central

[72] Li P, Merz KM, Jr. MCPB.py: A Python Based Metal Center Parameter Builder. J Chem Inf Model. 2016;56(4):599-604.10.1021/acs.jcim.5b00674Search in Google Scholar PubMed

[73] Case D, Pearlman D, Caldwell J. Amber 18.(2018) University of California. San Francisco.Search in Google Scholar

[74] Sommer Br, Dingersen T, Gamroth C, Schneider SE, Rubert S, Krüger J, et al. CELLmicrocosmos 2.2 MembraneEditor: a modular interactive shape-based software approach to solve heterogeneous membrane packing problems. Journal of chemical information and modeling. 2011;51(5):1165-82.10.1021/ci1003619Search in Google Scholar

[75] Chen F, Smith PE. Simulated surface tensions of common water models. American Institute of Physics; 2007.10.1063/1.2745718Search in Google Scholar

[76] Nasseri B. Effect of cholesterol and temperature on the elastic properties of niosomal membranes. International journal of pharmaceutics. 2005;300(1-2):95-101.10.1016/j.ijpharm.2005.05.009Search in Google Scholar

[77] Baranyai A, Evans DJ. New algorithm for constrained molecular-dynamics simulation of liquid benzene and naphthalene. Molecular Physics. 1990;70(1):53-63.10.1080/00268979000100841Search in Google Scholar

[78] Berendsen HJ, van der Spoel D, van Drunen R. GROMACS: a message-passing parallel molecular dynamics implementation. Computer physics communications. 1995;91(1-3):43-56.10.1016/0010-4655(95)00042-ESearch in Google Scholar

[79] Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of immunological methods. 1983;65(1-2):55-63.10.1016/0022-1759(83)90303-4Search in Google Scholar

[80] Peltonen L, Hirvonen J, Yliruusi J. The effect of temperature on sorbitan surfactant monolayers. Journal of colloid and interface science. 2001;239(1):134-8.10.1006/jcis.2001.7520Search in Google Scholar PubMed

[81] Allen WJ, Lemkul JA, Bevan DR. GridMAT-MD: a grid-based membrane analysis tool for use with molecular dynamics. Journal of computational chemistry. 2009;30(12):1952-8.10.1002/jcc.21172Search in Google Scholar PubMed

[82] Aferni AE, Guettari M, Tajouri T, Rahdar A. The confinement of PVP in AOT microemulsions: Effect of water content and PVP concentration regime on electrical percolation phenomenon. J Molecular Liquids. 2020;318:114012.10.1016/j.molliq.2020.114012Search in Google Scholar

[83] Arshad R, Pal K, Sabir F, Rahdar A, Bilal M, Shahnaz G, et al. A review of the nanomaterials use for the diagnosis and therapy of salmonella typhi. J Molecular Structure. 2021:129928.10.1016/j.molstruc.2021.129928Search in Google Scholar

[84] Heydari M, Yousefi AR, Rahdar A, Nikfarjam N, Jamshidi K, Bilal M, et al. Microemulsions of tribenuron-methyl using Pluronic F127: Physico-chemical characterization and efficiency on wheat weed. J Molecular Liquids. 2021;326:115263.10.1016/j.molliq.2020.115263Search in Google Scholar

[85] Pillai AM, Sivasankarapillai VS, Rahdar A, Joseph J, Sadeghfar F, Rajesh K, et al. Green synthesis and characterization of zinc oxide nanoparticles with antibacterial and antifungal activity. J Molecular Structure. 2020;1211:128107.10.1016/j.molstruc.2020.128107Search in Google Scholar

[86] Rahdar A, Aliahmad M, Samani M, HeidariMajd M, Susan MABH. Synthesis and characterization of highly efficacious Fe-doped ceria nanoparticles for cytotoxic and antifungal activity. Ceramics International. 2019;45(6):7950-5.10.1016/j.ceramint.2019.01.108Search in Google Scholar

[87] Rahdar A, Beyzaei H, Askari F, Kyzas GZ. Gum-based cerium oxide nanoparticles for antimicrobial assay. Applied Physics A. 2020;126(5):1-9.10.1007/s00339-020-03507-4Search in Google Scholar

[88] Moghaddam FD, Akbarzadeh I, Marzbankia E, Farid M, Reihani AH, Javidfar M, et al. Delivery of melittin-loaded niosomes for breast cancer treatment: an in vitro and in vivo evaluation of anti-cancer effect. 2021;12(1):1-35.10.1186/s12645-021-00085-9Search in Google Scholar

[89] Mandriota G, Di Corato R, Benedetti M, De Castro F, Fanizzi FP, Rinaldi RJAam, et al. Design and application of cisplatin-loaded magnetic nanoparticle clusters for smart chemotherapy. 2018;11(2):1864-75.10.1021/acsami.8b18717Search in Google Scholar PubMed

[90] Doijad R, Manvi F, Swati S, Rony MJId. Niosomal drug delivery of Cisplatin: Development and characterization. 2008;45(9):713-8.Search in Google Scholar

[91] Al-Bahlani SM, Al-Bulushi KH, Al-Alawi ZM, Al-Abri NY, Al-Hadidi ZR, Al-Rawahi SS. Cisplatin induces apoptosis through the endoplasmic reticulum-mediated, calpain 1 pathway in triple-negative breast cancer cells. Clinical Breast Cancer. 2017;17(3):e103-e12.10.1016/j.clbc.2016.12.001Search in Google Scholar PubMed

[92] Ag Seleci D, Seleci M, Walter J-G, Stahl F, Scheper T. Niosomes as nanoparticular drug carriers: fundamentals and recent applications. J nanomaterials. 2016;2016.10.1155/2016/7372306Search in Google Scholar

[93] Kanaani L, Tabrizi MM, Khiyavi AA, Javadi I. Improving the Efficacy of Cisplatin using Niosome Nanoparticles Against Human Breast Cancer Cell Line BT-20: An In Vitro Study. Asian Pacific J Cancer Biology. 2017;2(2):27-9.10.31557/apjcb.2017.2.2.27-29Search in Google Scholar

[94] Yang H, Deng A, Zhang J, Wang J, Lu B. Preparation, characterization and anticancer therapeutic efficacy of cisplatin-loaded niosomes. J microencapsulation. 2013;30(3):237-44.10.3109/02652048.2012.717116Search in Google Scholar PubMed

[95] Ciarimboli G. Membrane transporters as mediators of cisplatin side-effects. Anticancer research. 2014;34(1):547-50.Search in Google Scholar

[96] Gude R, Jadhav M, Rao S, Jagtap A. Effects of niosomal cisplatin and combination of the same with theophylline and with activated macrophages in murine B16F10 melanoma model. Cancer Biotherapy and Radiopharmaceuticals. 2002;17(2):183-92.10.1089/108497802753773801Search in Google Scholar PubMed

[97] Marianecci C, Di Marzio L, Rinaldi F, Celia C, Paolino D, Alhaique F, et al. Niosomes from 80s to present: the state of the art. Advances in colloid and interface science. 2014;205:187-206.10.1016/j.cis.2013.11.018Search in Google Scholar PubMed

[98] Khoee S, Yaghoobian M. Niosomes: A novel approach in modern drug delivery systems. Nanostructures for drug delivery: Elsevier; 2017. p. 207-37.10.1016/B978-0-323-46143-6.00006-3Search in Google Scholar

Received: 2021-10-16
Accepted: 2021-10-28
Published Online: 2021-12-17

© 2020 Saman Sargazi et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Downloaded on 1.3.2024 from https://www.degruyter.com/document/doi/10.1515/nanofab-2020-0100/html
Scroll to top button