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BY 4.0 license Open Access Published by De Gruyter Open Access December 30, 2021

Eco friendly synthesis and characterization of zinc oxide nanoparticles from Aegle marmelos and its cytotoxicity effects on MCF-7 cell lines

  • Manikandan Dhayalan EMAIL logo , Malathi Selvaraj , Kumar B Karthick , Riyaz S.U. Mohammed and Mika Sillanpää EMAIL logo
From the journal Nanofabrication


An attempt was made to synthesize zinc oxide gum white nanoparticles (ZnO-GWNPs) by the greenway approach using Aegle marmelos (Bael fruit) juice extract as a capping and reducing agent. Synthesis of ZnO-GWNPs by greener approach is safer, more economical, more energy-efficient, eco-friendlier, and less toxic than chemically synthesized counterparts. The optical properties of the ZnO-GWNPs were ascertained through UV-Vis spectroscopy, Fourier Transform-Infrared (FT-IR), X-ray diffraction (XRD), High-resolution transmittance electron microscopy (HRTEM). A characteristic absorption peak at 385nm confirmed the presence of ZnO-GWNP using UV-Vis spectroscopy. FTIR spectrum revealed that the characteristic absorption peak of the Zn-O bond was observed at 467 cm-1. The XRD result for the ZnO showed the tendency of the three most intense diffraction peaks. The average crystallite size ZnO NPs at scattering angle (2θ) 22.89 and 32.15 was 39.14 and 26.08 nm and it showed the presence of miller indices of (100), (002), (101), (102) respectively. The EDX spectrum gave strong signals for zinc and oxygen indicating the occurrence of the nanoparticles in their oxide form rather than the pure zinc form. The SEM image showed the surface morphology of ZnO-GW NPs and the HR-TEM image showed the crystalline nature of ZnO-GW NPs. Cytotoxicity study of ZnO-GW NPs was determined against MCF-7 cell lines and the IC50 values were found to be 40 µg/mL and 60 µg/mL at 24 h and 48 h respectively.


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Received: 2021-05-07
Accepted: 2021-11-19
Published Online: 2021-12-30

© 2021 Manikandan Dhayalan et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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