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BY 4.0 license Open Access Published by De Gruyter Open Access December 17, 2021

Development of mucoadhesive thiomeric chitosan nanoparticles for the targeted ocular delivery of vancomycin against Staphylococcus aureus resistant strains

  • Faryal Jahan , Shahiq uz Zaman , Sohail Akhtar , Rabia Arshad , Ibrahim Muhammad Ibrahim , Gul Shahnaz EMAIL logo , Abbas Rahdar EMAIL logo and Sadanand Pandey EMAIL logo
From the journal Nanofabrication


This study aims to formulate mucoadhesive vancomycin loaded thiolated chitosan (TCS) nanoparticles. These nanoparticles are mucoadhesive and enhance the retention of the drug at the ocular site. For this purpose, TCS loaded vancomycin nanoparticles were prepared by the ion-gelation method and were characterized for their size, shape, polydispersity index, mucoadhesion, cellular uptake and anti-inflammatory activity. The average size of the synthesized nanoparticles was found to be 288 nm with positive zeta potential. Moreover, 85% vancomycin was successfully encapsulated in TCS nanoparticles by using this method. A 2-fold increase in mucoadhesion was found as compared to non-thiolated vancomycin formulation (p < 0.05). Zone of inhibition of vancomycin loaded TCS was also significantly improved compared to non-thiolated chitosan nanoparticles and vancomycin alone. In-vivo anti-inflammatory evaluation via histopathology resulted in ocular healing. Based on the results, it is inferred that TCS nanoparticles are a promising drug delivery carrier system for ocular delivery of vancomycin.


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Received: 2021-10-12
Accepted: 2021-11-24
Published Online: 2021-12-17

© 2020 Faryal Jahan et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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