The crystal structure of ( Z )-4-amino- N ′ - (1-(4-hydroxyphenyl)propylidene)benzohydrazide,

C 16 H 17 N 3 O 2 , monoclinic, P 2 1 / n (no. 14), a = 9.3503(9) Å, b = 9.1998(8) Å, c = 17.7180(18) Å, β = 97.636(9) ° , V = 1510.6(3) Å 3 , Z = 4, R gt ( F ) = 0.0564, wR ref ( F 2 ) = 0.1439, T = 293 K.


Source of materials
A 50 mL round-bottom flask, equipped with a stir bar and rubber septum, was utilized for the experiment.75 mg of 4-aminobenzohydrazide (0.5 mmol) and 75 mg of 4-hydroxypropiophenone (0.5 mmol) were combined with 25 mL of absolute alcohol in the flask.Following that, 3 drops of glacial acetic acid were added, and the resulting solution was stirred at room temperature for 20 min.The stirring was then continued for additional 5 h at 80 °C.Afterward, the solvent was evaporated using a rotary evaporator to obtain the crude product.Subsequently, the crude product was dissolved in a minimal amount of hot ethanol under controlled heating conditions, and the solution was gradually cooled to room temperature.During this cooling process, a single crystal was observed.The single crystal of the title compound was obtained after 5 days through slow solvent volatilization at room temperature.

Experimental details
The single crystal X-ray diffraction experiment utilized a Bruker APEX-II CCD [1].SHELXT [2] and SHELXL [3] software packages were employed to solve and refine the crystal structure.The OLEX2 [4] and VESTA [5] software packages were utilized for the visualization of the crystal structure.

Comment
The acylated derivatives of hydrazine exhibit various biological activities, such as antibacterial, antifungal, insecticidal,  and anticonvulsant properties.Additionally, they serve as crucial raw materials for pharmaceutical products, surfactants, and various derivatives [6].Among them, benzoyl hydrazine derivatives have been extensively studied due to their wide range of biological activities.Multiple crystal structures of these compounds have been reported [7][8][9][10][11].Previous studies on their single crystal structures have revealed the presence of different conformations around the C=N double bond, as well as the occurrence of intermolecular hydrogen bonding and π-π interactions [12][13][14][15][16].
The crystal structure of (Z)-4-amino-N′-(1-(4-hydroxyphenyl)propylidene) benzohydrazide exhibits a Z-type conformation.The 4-aminophenylformamide group and 4-hydroxyphenyl group are located on the same side of the C=N double bond.The two benzene rings undergo significant torsion, with an almost perpendicular arrangement.

Table  :
Data collection and handling.

Table  :
Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å  ).