Skip to content
BY 4.0 license Open Access Published by De Gruyter Open Access October 11, 2022

Potential Role of Functional Foods in the Management of SARS-CoV-2 Omicron Variant

  • V Venugopal , B deenadayalan , S Poonguzhali and K Maheshkumar EMAIL logo
From the journal Open Health

Abstract

Omicron is a more contagious variant of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), commonly known as Coronavirus disease 2019 (COVID- 19). Dietary management of COVID-19 with functional foods plays a significant role in reducing cytokine storm and the viral replication and survival. A thorough literature search was performed in electronic databases such as PubMed and EMBASE using the keywords Coronavirus, COVID-19, Omicron, functional foods, and phytonutrient. In total, 77 research articles were identified; of those, 10 papers were included after title, abstract and full text review. Most commonly used phytonutrients for the management of COVID-19 include bromelain, curcumin, quercetin, gingerol and epigallocatechin gallate (EGCG). These phytonutrients possessed anti-inflammatory properties, and were effective in targeting the spike proteins and docking sites of the SARS-CoV-2 virus, thereby preventing viral replication and survival. To the best of our knowledge, this is the first published review indicating the significance of functional foods in reducing the severity of the Omicron variant.

References

[1] Gowrisankar A, Priyanka TM, Banerjee S. Omicron: a mysterious variant of concern. Eur Phys J Plus. 2022;137(1):100.10.1140/epjp/s13360-021-02321-ySearch in Google Scholar PubMed PubMed Central

[2] Aman F, Masood S. How Nutrition can help to fight against COVID-19 Pandemic. Pak J Med Sci. 2020 May;36(COVID19- S4):S121-S12310.12669/pjms.36.COVID19-S4.2776Search in Google Scholar PubMed PubMed Central

[3] Beidelschies M, Alejandro-Rodriguez M, Ji X, Lapin B, Hanaway P, Rothberg MB. Association of the functional medicine model of care with patient-reported healthrelated quality-of-life outcomes. JAMA Netw Open. 2019 Oct;2(10):e1914017–1914017.10.1001/jamanetworkopen.2019.14017Search in Google Scholar PubMed PubMed Central

[4] Hosseini F, Bahramimeimandi B, Raoufi E, Mozafari MR. Prevention of SARS-CoV-2 Infection: A Liposomal Functional Food Approach. Int J Prev Med. 2021 Mar;12(3):26.Search in Google Scholar

[5] Raoufi E, Bahramimeimandi B, Salehi-Shadkami M, Chaosri P, Mozafari MR. Methodical design of viral vaccines based on avant-Garde nanocarriers: A multi-domain narrative review. Biomedicines. 2021 May;9(5):520.10.3390/biomedicines9050520Search in Google Scholar PubMed PubMed Central

[6] Kritis P, Karampela I, Kokoris S, Dalamaga M. The combination of bromelain and curcumin as an immuneboosting nutraceutical in the prevention of severe COVID-19. Metab Open. 2020 Dec;8:100066.10.1016/j.metop.2020.100066Search in Google Scholar PubMed PubMed Central

[7] Sagar S, Kumar Rathinavel A, Lutz WE, Struble LR, Khurana S, Schnaubelt AT, et al. Bromelain Inhibits SARS-CoV-2 Infection in VeroE6 Cells. bioRxiv 2020.09.16.297366 [Preprint]. 2020 [cited 2022 Sep 12]. Available from: https://www.biorxiv.org/content/10.1101/2020.09.16.297366v110.1101/2020.09.16.297366Search in Google Scholar PubMed PubMed Central

[8] Soni VK, Mehta A, Ratre YK, Tiwari AK, Amit A, Singh RP, et al. Curcumin, a traditional spice component, can hold the promise against COVID-19? Eur J Pharmacol. 2020 Nov;886:173551.10.1016/j.ejphar.2020.173551Search in Google Scholar PubMed PubMed Central

[9] Liu Z, Ying Y. The inhibitory effect of curcumin on virus-induced cytokine storm and its potential use in the associated severe pneumonia. Front Cell Dev Biol. 2020 Jun;8:479.10.3389/fcell.2020.00479Search in Google Scholar PubMed PubMed Central

[10] Colunga Biancatelli RM, Berrill M, Catravas JD, Marik PE. Quercetin and vitamin C: an experimental, synergistic therapy for the prevention and treatment of SARS-CoV-2 related disease (COVID-19). Front Immunol. 2020 Jun;11:1451.10.3389/fimmu.2020.01451Search in Google Scholar PubMed PubMed Central

[11] Sano M, Tabata M, Suzuki M, Degawa M, Miyase T, Maeda-Yamamoto M. Simultaneous determination of twelve tea catechins by high-performance liquid chromatography with electrochemical detection. Analyst (Lond). 2001 Jun;126(6):816–20.10.1039/b102541bSearch in Google Scholar PubMed

[12] Khan MF, Khan MA, Khan ZA, Ahamad T, Ansari WA. Identification of dietary molecules as therapeutic agents to combat COVID-19 using molecular docking studies. Research square [Preprint]. 2020 [cited 2022 Sep 22]. Available from: https://doi.org/10.21203/rs.3.rs-19560/v1.10.21203/rs.3.rs-19560/v1Search in Google Scholar

[13] Menegazzi M, Campagnari R, Bertoldi M, Crupi R, Di Paola R, Cuzzocrea S. Protective effect of epigallocatechin-3-gallate (EGCG) in diseases with uncontrolled immune activation: could such a scenario be helpful to counteract COVID-19? Int J Mol Sci. 2020 Jul;21(14):5171.10.3390/ijms21145171Search in Google Scholar PubMed PubMed Central

[14] Jafarzadeh A, Jafarzadeh S, Nemati M. Therapeutic potential of ginger against COVID-19: is there enough evidence? J Tradit Chin Med Sci. 2021;8(4):267–79.10.1016/j.jtcms.2021.10.001Search in Google Scholar

[15] Kumar Verma A, Kumar V, Singh S, Goswami BC, Camps I, Sekar A, et al. Repurposing potential of Ayurvedic medicinal plants derived active principles against SARS-CoV-2 associated target proteins revealed by molecular docking, molecular dynamics and MM-PBSA studies. Biomed Pharmacother. 2021 May;137:111356.10.1016/j.biopha.2021.111356Search in Google Scholar PubMed PubMed Central

Received: 2022-04-15
Accepted: 2022-09-06
Published Online: 2022-10-11

© 2022 V Venugopal et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Downloaded on 1.12.2023 from https://www.degruyter.com/document/doi/10.1515/openhe-2022-0025/html
Scroll to top button