Accessible Requires Authentication Published by De Gruyter October 17, 2017

Organometallic chemical biology: an organometallic approach to bioconjugation

Ekaterina V. Vinogradova

Abstract

This review summarizes the history and recent developments of the field of organometallic chemical biology with a particular emphasis on the development of novel bioconjugation approaches. Over the years, numerous transformations have emerged for biomolecule modification with the use of organometallic reagents; these include [3+2] cycloadditions, C–C, C–S, C–N, and C–O bond forming processes, as well as metal-mediated deprotection (“decaging”) reactions. These conceptually new additions to the chemical biology toolkit highlight the potential of organometallic chemistry to make a significant impact in the field of chemical biology by providing further opportunities for the development of chemoselective, site-specific and spatially resolved methods for biomolecule structure and function manipulation. Examples of these transformations, as well as existing challenges and future prospects of this rapidly developing field are highlighted in this review.

Acknowledgements

I am truly grateful to Profs. Stephen L. Buchwald and Bradley L. Pentelute for their continuous support during my graduate studies at the Massachusetts Institute of Technology and for assembling an outstanding group of coworkers providing a stimulating scientific environment. I would also like to thank Prof. Benjamin F. Cravatt for opening the doors of his lab for my post-doctoral training, his encouragement and insightful discussions. Prof. Alex M. Spokoyny, Dr. Sean Reed, Prof. Simon Meek are acknowledged for their critical input during the preparation of this manuscript. E. V. V. is currently the recipient of the Life Sciences Research Foundation Fellowship sponsored by Pfizer. The content of this manuscript is solely the responsibility of the author and does not represent the official views of LSRF.

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Published Online: 2017-10-17
Published in Print: 2017-10-26

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