Abstract
The Australia Group (AG) is a forum of like-minded states seeking to harmonize export controls to prevent the proliferation of chemical and biological weapons. The AG Chemical Weapons Precursors list features dual-use chemicals that can be used as precursors for the synthesis of chemical weapons, all individually enumerated. This is in contrast with the Chemical Weapons Convention (CWC) Schedules, which, alongside entries describing discrete chemicals, also include entries that describe families of chemicals. By using families of chemicals, the CWC achieves the objective of covering with a single entry a wide array of related chemicals of concern, including chemicals that have not yet been made. There are practical reasons why the AG Chemical Weapons Precursors list is exclusively based on the enumeration of individual chemicals. A cheminformatics tool of which we have developed a prototype, the Nonproliferation Compliance Cheminformatics Tool (NCCT), has the potential to enable export control officers to handle control lists that contain families of chemicals. Thus, it opens the way to expand the AG Chemical Weapons Precursors list to a family-based approach for some of its entries. Such a change would result in a closer alignment of the chemical space covered by the AG Chemical Weapons Precursors list with that covered by the CWC Schedules, thus closing loopholes that could be exploited by proliferators.
Article note:
A collection of invited papers based on presentations at the Virtual Conference on Chemistry and its Applications 2022 (VCCA-2022) held on-line, 8–12 August 2022.
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Research funding: This work was supported by Global Affairs Canada under award CWC-2022-0002 (P0011281).
References
[1] S. Costanzi. Kirk-Othmer Encyclopedia of Chemical Technology, pp. 1–32, Wiley Online Library (2020).10.1002/0471238961.0308051308011818.a01.pub3Search in Google Scholar
[2] OPCW. The Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on their Destruction, https://www.opcw.org/chemical-weapons-convention.Search in Google Scholar
[3] R. K. Hersman, W. Pittinos. in Restoring Restraint: Enforcing Accountability for Users of Chemical Weapons, Rowman & Littlefield, Lantham, MD (2018).Search in Google Scholar
[4] R. K. Hersman, S. Claeys. Rigid Structures, Evolving Threat: Preventing the Proliferation and Use of Chemical Weapons, Center for Strategic & International Studies (2019).Search in Google Scholar
[5] The Australia Group. The Australia Group: An Introduction, https://www.dfat.gov.au/publications/minisite/theaustraliagroupnet/site/en/precursors.html.Search in Google Scholar
[6] J. I. Seevaratnam. Nonproliferation Rev. 13, 401 (2006), https://doi.org/10.1080/10736700601012227.Search in Google Scholar
[7] The Australia Group. Chemical Weapons Precursors, https://www.dfat.gov.au/publications/minisite/theaustraliagroupnet/site/en/precursors.html.Search in Google Scholar
[8] R. J. Mathews. Chem. Weapons Convent. Bull. 1, 1–3 (1993).Search in Google Scholar
[9] S. Costanzi, C. K. Slavick, B. O. Hutcheson, G. D. Koblentz, R. T. Cupitt. J. Chem. Inf. Model. 60, 4804 (2020), https://doi.org/10.1021/acs.jcim.0c00896.Search in Google Scholar PubMed
[10] OPCW. Annex on Chemicals, https://www.opcw.org/chemical-weapons-convention/annexes/annex-chemicals/annex-chemicals.Search in Google Scholar
[11] G. Pontes, J. Schneider, P. Brud, L. Benderitter, B. Fourie, C. Tang, C. M. Timperley, J. E. Forman. J. Chem. Educ. 97, 1715 (2020), https://doi.org/10.1021/acs.jchemed.0c00547.Search in Google Scholar
[12] C. M. Timperley, J. E. Forman. J. Chem. Educ. 98, 1468 (2021), https://doi.org/10.1021/acs.jchemed.1c00134.Search in Google Scholar
[13] S. Costanzi, G. D. Koblentz, R. T. Cupitt. Strat. Trade Rev. 6, 69 (2020).Search in Google Scholar
[14] M. Kloske, Z. Witkiewicz. Chemosphere 221, 672 (2019), https://doi.org/10.1016/j.chemosphere.2019.01.054.Search in Google Scholar PubMed
[15] S. Costanzi, J.-H. Machado, M. Mitchell. ACS Chem. Neurosci. 9, 873 (2018), https://doi.org/10.1021/acschemneuro.8b00148.Search in Google Scholar PubMed
[16] S. Costanzi, G. D. Koblentz. Nonproliferation Rev. 26, 1 (2019).10.1080/10736700.2019.1615757Search in Google Scholar
[17] S. Costanzi, G. D. Koblentz. Arms Control Today 50, 16 (2020).Search in Google Scholar
[18] S. Costanzi, G. D. Koblentz. Nonproliferation Rev. 0, 1 (2022).Search in Google Scholar
[19] The Australia Group. Australia Group Common Control List Handbook, https://www.dfat.gov.au/sites/default/files/australia-group-common-control-list-handbook-volume-i.pdf.Search in Google Scholar
[20] S. Costanzi, C. K. Slavick, J. M. Abides, G. D. Koblentz, M. Vecellio, R. T. Cupitt. Pure Appl. Chem. 94, 783 (2022), https://doi.org/10.1515/pac-2021-1107.Search in Google Scholar
[21] ChemAxon. Instant IChem, https://chemaxon.com/products/instant-jchem.Search in Google Scholar
[22] D. Taylor, S. G. Bowden, R. Knorr, D. R. Wilson, J. Proudfoot, A. E. Dunlop. Drug Discov. Today 20, 175 (2015), https://doi.org/10.1016/j.drudis.2014.09.021.Search in Google Scholar PubMed
[23] Scitegrity. Controlled Substances Squared, https://scitegrity.co.uk/index.php?page=cs2.Search in Google Scholar
[24] ChemAxon. Compliance Checker, https://chemaxon.com/products/compliance-checker.Search in Google Scholar
[25] D. Weininger. J. Chem. Inf. Comput. Sci. 28, 31 (1988), https://doi.org/10.1021/ci00057a005.Search in Google Scholar
[26] D. Weininger, A. Weininger, J. L. Weininger. J. Chem. Inf. Comput. Sci. 29, 97 (1989), https://doi.org/10.1021/ci00062a008.Search in Google Scholar
[27] S. R. Heller, A. McNaught, I. Pletnev, S. Stein, D. Tchekhovskoi. J. Cheminf. 7, 23 (2015), https://doi.org/10.1186/s13321-015-0068-4.Search in Google Scholar PubMed PubMed Central
[28] C. M. Timperley, J. E. Forman, M. Abdollahi, A. S. Al-Amri, I. P. Alonso, A. Baulig, V. Borrett, F. A. Cariño, C. Curty, D. Gonzalez, Z. Kovarik, R. Martínez-Álvarez, R. Mikulak, N. M. Fusaro Mourão, P. Ramasami, S. Neffe, S. K. Raza, V. Rubaylo, K. Takeuchi, C. Tang, F. Trifirò, F. M. van Straten, P. S. Vanninen, V. Zaitsev, F. Waqar, M. S. Zina, S. Holen, H. A. Weinstein. Pure Appl. Chem. 90, 1647 (2018), https://doi.org/10.1515/pac-2018-0803.Search in Google Scholar
[29] OPCW. Response to the Director-General’s request to the Scientific Advisory Board to provide further advice on scheduled chemicals, SAB-23/WP.1 (2016), https://www.opcw.org/sites/default/files/documents/CSP/RC-4/en/rc4dg01_e_.pdf.Search in Google Scholar
[30] OPCW. Report of The Scientific Advisory Board on Developments in Science and Technology for the Fourth Special Session of the Conference of the States Parties to Review Figure the Operation of the Chemical Weapons Convention, RC-4/DG.1, pp. 30–31 (2018), https://www.opcw.org/sites/default/files/documents/CSP/RC-4/en/rc4dg01_e_.pdf.Search in Google Scholar
[31] International Trade Administration. Special Documents used in Exporting, https://www.trade.gov/special-documents.Search in Google Scholar
[32] OSHA. Hazard Communication Standard: Safety Data Sheets, https://www.osha.gov/sites/default/files/publications/OSHA3514.pdf.Search in Google Scholar
[33] UNECE. Globally Harmonized System of Classification and Labelling of Chemicals (GHS) – Eighth revised edition, p. 37, https://unece.org/fileadmin/DAM/trans/danger/publi/ghs/ghs_rev08/ST-SG-AC10-30-Rev8e.pdf.Search in Google Scholar
[34] OPCW. Annex on Chemicals – Schedule 1, https://www.opcw.org/chemical-weapons-convention/annexes/annex-chemicals/schedule-1.Search in Google Scholar
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