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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access March 31, 2015

Unravelling peptidomes by in silico mining

  • Johannes Koehbach and Kathryn A.V. Jackson
From the journal Peptidomics


Peptides of great number and diversity occur in all domains of life and exhibit a range of pharmaceutically relevant bioactivities. The complexity of biological samples including human cells or tissues, plant extracts or animal venom cocktails, often impedes the discovery of novel bioactive peptides using mass spectrometrybased peptidomics analysis. An increasing number of publicly available genome and transcriptome datasets, together with refined bioinformatics analysis, allows for rapid identification of novel peptides which may have been previously unrecognized. Moreover, a combination of information extracted from in silico mining approaches together with data derived from mass spectrometrybased studies provides new impetus for future peptidome analyses, including the discovery of novel bioactive peptides that can serve as starting points for drug development.


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Received: 2014-12-1
Accepted: 2015-2-11
Published Online: 2015-3-31

© 2015 Johannes Koehbach, Kathryn A.V. Jackson

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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