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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access January 20, 2016

Serum metal evaluation in a small cohort of Amyotrophic Lateral Sclerosis patients reveals high levels of thiophylic species

  • Stefano De Benedetti , Giorgio Lucchini , Alessandro Marocchi , Silvana Penco , Christian Lunetta , Stefania Iametti , Elisabetta Gianazza and Francesco Bonomi
From the journal Peptidomics


Amyotrophic Lateral Sclerosis (ALS) has often been associated with improper/altered metal metabolism. Analysis of thiophylic metals in serum from a small and geographically restricted cohort of ALS patients indicates contents of Pb and Ni much higher in patients than in controls (Ni, 5-fold; Pb, 2-fold). Se levels are also higher in the patients’ group, which has instead lower As levels than controls. Thiophylic metals may impair biogenesis of FeS clusters or substitute for iron, even in folded proteins; Se may non-functionally replace S. Thus, improper assembly/ function of FeS proteins could represent another possible issue to be considered in ALS pathogenesis.


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Received: 2015-7-28
Accepted: 2015-10-16
Published Online: 2016-1-20

© 2015 Stefano De Benedetti et al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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