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Licensed Unlicensed Requires Authentication Published by De Gruyter March 16, 2015

Non-invasive detection of free hemoglobin in red blood cell concentrates for quality assurance

Nicht-invasive Bestimmung des freien Hämoglobins in Erythrozytenkonzentraten zur Qualitätssicherung
  • Uwe J. Netz EMAIL logo , Lesley Hirst and Moritz Friebel


There is currently no non-invasive measurement method available on the market for the quality control of red cell concentrates (RCCs). As the level of free hemoglobin is an indicator for hemolysis resulting from destroyed or overaged red blood cells, it is an important parameter to assess the quality and usability of RCCs before transfusion. A new optical device has been developed and tested to enable the measurement of the free hemoglobin concentration non-invasively in RCCs.


Zurzeit ist keine Methode zur nicht-invasiven Qualitätskontrolle von Erythrozytenkonzentraten verfügbar. Das freie Hämoglobin ist ein Maß für die Hämolyse, welche die Schädigung oder überalterung der roten Blutkörperchen anzeigt und daher ein wichtiger Parameter für die Beurteilung der Qualität und der Verwendbarkeit der Erythrozytenkonzentrate vor der Transfusion ist. Ein neues Gerät zur optischen nicht-invasiven Messung der Konzentration von freiem Hämoglobin in Erythrozytenkonzentraten wurde entwickelt und getestet.

Corresponding author: Uwe J. Netz, Laser- und Medizin-Technologie GmbH, Berlin (LMTB), Fabeckstr. 60-62, 14195 Berlin, Germany, e-mail:


Financial support by Berlin Senate Department of Commerce, Technology and Research (IBB, ProFIT 10147774), co-financed by the European Fund for Regional Development (EFRE) is gratefully acknowledged. Our thanks go to the DRK-Blutspendedienst Nord-Ost for their help in supplying us with blood products.

  1. Conflict of interest statement: There is no conflict of interest to report.


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Received: 2014-12-12
Revised: 2015-2-18
Accepted: 2015-2-20
Published Online: 2015-3-16
Published in Print: 2015-5-1

©2015 Walter de Gruyter GmbH, Berlin/Boston

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