Non-invasive detection of free hemoglobin in  red blood cell concentrates for quality assurance:

Uwe J. Netz; Lesley Hirst; Moritz Friebel

doi:10.1515/plm-2014-0054

Published by De Gruyter March 16, 2015

Non-invasive detection of free hemoglobin in red blood cell concentrates for quality assurance

Nicht-invasive Bestimmung des freien Hämoglobins in Erythrozytenkonzentraten zur Qualitätssicherung

Uwe J. Netz , Lesley Hirst and Moritz Friebel

From the journal Photonics & Lasers in Medicine

https://doi.org/10.1515/plm-2014-0054

Showing a limited preview of this publication:

Abstract

There is currently no non-invasive measurement method available on the market for the quality control of red cell concentrates (RCCs). As the level of free hemoglobin is an indicator for hemolysis resulting from destroyed or overaged red blood cells, it is an important parameter to assess the quality and usability of RCCs before transfusion. A new optical device has been developed and tested to enable the measurement of the free hemoglobin concentration non-invasively in RCCs.

Zusammenfassung

Zurzeit ist keine Methode zur nicht-invasiven Qualitätskontrolle von Erythrozytenkonzentraten verfügbar. Das freie Hämoglobin ist ein Maß für die Hämolyse, welche die Schädigung oder überalterung der roten Blutkörperchen anzeigt und daher ein wichtiger Parameter für die Beurteilung der Qualität und der Verwendbarkeit der Erythrozytenkonzentrate vor der Transfusion ist. Ein neues Gerät zur optischen nicht-invasiven Messung der Konzentration von freiem Hämoglobin in Erythrozytenkonzentraten wurde entwickelt und getestet.

Keywords: hemolysis; optical; sensor; quality control; storage lesion; blood; tubing

Schlüsselwörter: Hämolyse; optisch; Sensor; Qualitätskontrolle; Lagerungsschäden; Blut; Schlauch

Corresponding author: Uwe J. Netz, Laser- und Medizin-Technologie GmbH, Berlin (LMTB), Fabeckstr. 60-62, 14195 Berlin, Germany, e-mail: u.netz@LMTB.de

Acknowledgments

Financial support by Berlin Senate Department of Commerce, Technology and Research (IBB, ProFIT 10147774), co-financed by the European Fund for Regional Development (EFRE) is gratefully acknowledged. Our thanks go to the DRK-Blutspendedienst Nord-Ost for their help in supplying us with blood products.

Conflict of interest statement: There is no conflict of interest to report.

References

[1] Commission Directive 2004/33/EC of 22 March 2004 implementing Directive 2002/98/EC of the European Parliament and of the Council as regards certain technical requirements for blood and blood components. http://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32004L0033 [Accessed on January 7, 2015].Search in Google Scholar

[2] Council of Europe. Guide to the preparation, use and quality assurance of blood components. 16th edition. Strasbourgh: Council of Europe Publishing; 2010.Search in Google Scholar

[3] Sowemimo-Coker SO. Red blood cell hemolysis during processing. Transfus Med Rev 2002;16(1):46–60.10.1053/tmrv.2002.29404Search in Google Scholar PubMed

[4] Meinke M, Friebel M, Helfmann J, Notter M. A novel device for the non-invasive measurement of free hemoglobin in blood bags. Biomed Tech (Berl) 2005;50(1–2):2–7.10.1515/BMT.2005.001Search in Google Scholar PubMed

Received: 2014-12-12

Revised: 2015-2-18

Accepted: 2015-2-20

Published Online: 2015-3-16

Published in Print: 2015-5-1