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Licensed Unlicensed Requires Authentication Published by De Gruyter April 21, 2020

Ion exchange in downstream processing in biotechnology

  • Venko N. Beschkov EMAIL logo
From the journal Physical Sciences Reviews


Ion exchange is one of the promising methods for downstream processing in biotechnology. Its advantages are based on selectivity and therefore obtaining of products with reasonable concentration and purity, mild conditions, simple operation and saving of time and energy for product separation. Additional advantage is the possible in situ extraction of ionogenic products from the fermentation broth, including removal of potential inhibitors during the fermentation process.

In the case of biotechnology, ion exchange could be considered in two separate ways: ion-exchange solvent extraction and traditional liquid/solid ion exchange by ion-exchange resins. Both approaches have been studied.

In this paper, this approach is shown on two important case studies: L(+)-lactic acid and L-lysine recovery from fermentation processes.


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