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Licensed Unlicensed Requires Authentication Published by De Gruyter April 19, 2021

Poly(glycerol sebacate) – a revolutionary biopolymer

  • Israd H. Jaafar EMAIL logo , Sabrina S. Jedlicka and John P. Coulter
From the journal Physical Sciences Reviews


Novel materials possessing physical, mechanical, and chemical properties similar to those found in vivo provide a potential platform for building artificial microenvironments for tissue engineering applications. Poly(glycerol sebacate) is one such material. It has tunable mechanical properties within the range of common tissue, and favorable cell response without surface modification with adhesive ligands, and biodegradability. In this chapter, an overview of the material is presented, focusing on synthesis, characterization, microfabrication, use as a substrate in in vitro mammalian cell culture, and degradation characteristics.

Corresponding author: Israd H. Jaafar, Mechanical Engineering, Utah Valley University, 800 W University Parkway, Orem, UT, USA, E-mail:

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.


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Published Online: 2021-04-19

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