Accessible Requires Authentication Published by Oldenbourg Wissenschaftsverlag November 4, 2015

Optimized separation procedure for production of no-carrier-added radiomanganese for positron emission tomography

Martin Buchholz, Ingo Spahn and Heinz H. Coenen
From the journal Radiochimica Acta


The natCr(p, xn)-process is a very efficient route for production of 52gMn (T1/2 = 5.59 d). Based on measurements of distribution coefficients with different media and ion-exchange resins, an optimized chromatographic separation of radiomanganese from natCr with the resin Amberlite CG400 was developed. With this system natCr is eluted first with an acetic acid/methanol 1:1 mixture at room temperature and 52gMn thereafter with 3 M HCl at 50 ℃. Within a separation time of 4 h the method yielded 99.5% of the n.c.a. 52gMn in 2–3 mL of 3 M HCl. An ICP-MS analysis revealed a chromium impurity of 0.07 mg (0.014%) in the n.c.a. 52gMn solution, making this separation method suitable for the production of 52gMn for medical applications like positron emission tomography (PET).


The authors would like to thank Prof. Dr. Dr. h.c. mult. S. M. Qaim for very helpful discussions and his constructive advice. Sincere thanks also go to Mr. Holzgreve, Mr. Adrian, and Mr. Spellerberg involved in the cyclotron irradiations and radionuclide production.

Received: 2015-9-4
Accepted: 2015-10-12
Published Online: 2015-11-4
Published in Print: 2015-12-28

©2015 Walter de Gruyter Berlin/Boston