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Licensed Unlicensed Requires Authentication Published by De Gruyter (O) October 21, 2017

Preparation and biological evaluation of 99mTc N-histamine as a model for brain imaging: in silico study and preclinical evaluation

  • M. H. Sanad EMAIL logo and Alhussein A. Ibrahim
From the journal Radiochimica Acta


In the present work, [99mTc]N-histamine has been labeled using [99mTc≡N]2+ core. Factors such as, amount of substrate, pH, reaction temperature, in vitro stability and reaction time, have been systematically studied to optimize high radiochemical purity (>99±0.3). Biodistribution studies indicate the suitability of [99mTc]N-histamine as a novel tracer to image brain. The complex of [99mTc]N-histamine may be considered a highly selective radiotracer for brain imaging.


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Received: 2017-4-9
Accepted: 2017-9-20
Published Online: 2017-10-21
Published in Print: 2018-3-28

©2018 Walter de Gruyter GmbH, Berlin/Boston

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