Skip to content
BY 4.0 license Open Access Published by De Gruyter (O) May 13, 2022

Nuclear data for light charged particle induced production of emerging medical radionuclides

  • Gaia Pupillo EMAIL logo , Liliana Mou , Simone Manenti EMAIL logo , Flavia Groppi , Juan Esposito and Ferid Haddad
From the journal Radiochimica Acta


Whatever the radionuclide to be used in nuclear medicine, it is essential to know the expected yield during the production process, but also of all the possible radionuclidic impurities coproduced, that can have an impact on the product final quality, as well as in the related waste management. The availability of the majority of emerging radioisotopes, including the theranostic ones or pairs, is mainly limited by the fact that, for most of them, the optimal production route still needs to be strengthened if not defined in some cases. The aim of this work is to present a review on the charged particle induced nuclear cross sections to produce some emerging radionuclides for medical applications to show that all types of projectiles should be considered in the quest of producing medical radionuclides. An accurate analysis of the production routes is presented for some radionuclides (67Cu, 47Sc, 89Zr, 103Pd, 186gRe, 97Ru, 211At) chosen as examples to highlight (i) how the quality of the final product strongly depends on the chosen target/projectile/energy parameters set, (ii) how deuteron production routes may sometimes be more effective than the proton ones or lead to a different impurity profile and (iii) how α-particle beams may allow to bypass the limitations occurring when using Z = 1 beams. An overview of possible advantages and drawbacks of the cited production routes and of potential cross sections that still need to be measured, is also reported.

1 Introduction

1.1 Radionuclides in nuclear medicine

Nuclear Medicine is a medical field that uses radionuclides both for diagnosis and therapy. The physical characteristics of radioactive decay of radionuclides determine their use in nuclear medicine [1], [2], [3]. In most cases, radionuclides must be labelled to a vector molecule, forming what is commonly called a radiopharmaceutical. The vector molecule allows to efficiently target a dedicated cell type, due to its high affinity for it, or for a specific function of the human organ. In general, radionuclides employed in nuclear medicine both for diagnostic and therapeutic purposes, should meet the following specific requirements:

  1. appropriate physical properties for the selected application, in terms of half-life (T1/2), decay mode and radiation emission energy;

  2. suitable chemical properties to allow their labelling to a vector molecule with high radiochemical yields through the labelling process;

  3. ability to deliver an appropriate radiation dose to the target tissue, sufficient to accomplish the intended clinical duty (diagnosis or therapy), but without causing damages to the patient;

  4. an appropriate purity, as the vector molecule can be expensive or the number of targeted sites limited;

  5. a reasonable price.

A new frontier of nuclear medicine is the so-called “theranostic approach” that combines therapy and diagnosis stages (preferentially PET imaging that can give a quantitative dosimetry) [4], and which includes a single radiopharmaceutical that:

  1. has both diagnostic and therapeutic properties, i.e. a bioactive molecule labelled with an isotope whose radiation decay pattern is suitable both for diagnosis and therapy, such as 47Sc, 67Cu, 67Ga, 111In, 117mSn 123I, 131I, 153Sm, 177Lu, 186Re, 213Bi, etc.; as previously noted, the use of gamma-emitters instead of positron-emitters is recently attracting considerable interest [4];

  2. can be labelled with different radioisotopes of the same element, one being utilized for diagnosis while the other one for therapy, such as 43/44Sc/47Sc, 61/64Cu/67Cu, 68Ga/67Ga, 86Y/90Y, 124I/131I, the terbium family 149/152Tb/155/161Tb, etc. [5];

  3. can be labelled with different isotopes each belonging to a different element but having similar chemical properties (surrogate pair), where one radionuclide is utilized for diagnosis and the other for therapy, such as 68Ga/177Lu, 68Ga/therapeutic lanthanide, etc.

The theranostic approach allows for collecting pre-therapy information with low-dose diagnostic imaging, aimed at optimizing the following high-dose therapeutic administration to the patient [6]. This strategy is getting closer to the realization of personalized medicine, in which low-dose molecular imaging performed with SPECT/CT or PET/CT is a necessary step to provide preliminary information about biodistribution, dosimetry on the tumor and limiting or critical organs or tissues, and the maximum tolerable dose [7].

Whatever the radionuclide to be used in nuclear medicine, it is thus essential to get knowledge of the possible presence of coproduced radionuclidic impurities that can have an impact on the final product quality and in the waste management during the production process or in the use at the hospital. Moreover, the availability of the majority of theranostic radionuclides is mainly limited by the fact that most of them are currently emerging and the optimal production route still needs to be improved or defined [8, 9].

1.2 The use of accelerators for emerging medical radionuclides production

Most of the radionuclides used in nuclear medicine are artificially produced by using either nuclear reactors or accelerators delivering charged particle beams or inducing a γ-irradiation. This work is focused on light-charged particles induced reactions, even if there is an increasing interest on photo-production as for example for 47Sc, 67Cu, etc. [10], [11], [12].

In order to select the optimal way to produce a given radionuclide, it is mandatory to explore all possible nuclear reaction routes and thus to measure the nuclear cross sections for the concerned radioisotope, as well as of related main contaminants. Among the possible production routes, proton or light-charged particles (e.g. deuteron, 3He and 4He) are of great potential, mainly for positron emitters and some therapeutic radionuclides [13, 14]. In recent years, high energy (70 MeV) and multi particle accelerators have been made available from accelerators’ manufacturers. This allows to widen the range of possible nuclear reaction routes which may be explored and radionuclides that may be thus produced (e.g. 211At or 82Sr, 68Ge, etc.). Examples in Europe are the ARRONAX facility [15] and the SPES cyclotron used in the LARAMED project [16].

1.3 The importance of accurate nuclear cross section determination and thick target yields (TTY) measurements in medical radionuclides production

By definition, the cross section σ(E) is the probability of a specific nuclear reaction to occur at the given energy E, i.e. the interaction probability of one bombarding particle and one target atom. This quantity is required to calculate the production yield of the radionuclide of interest. Indeed, the resulting activity at the End Of Bombardment (TTYEOB) of a given radionuclide, produced by a particle beam hitting a thick target, which also depends on the irradiation time tIRR and the decay constant λ [s−1], is calculated considering the following formula [3, 17]:

(1) T T Y E O B = N A N b A T ( 1 e λ t i r r ) E o u t E i n σ ( E ) d E S T ( E )

where N A is the Avogadro constant [mol−1], N b is the number of bombarding particles [s−1], A T is the atomic weight of the target material [g⋅mol−1] and S T(E) is the mass stopping power of the particle beam through the target material at the energy E, expressed as dE/d(ρx). The term ( 1 e λ t i r r ) is the so-called saturation factor (SF) that takes into account both the production of nuclei due to the considered nuclear reaction and the decay of nuclei that have already been produced. In a thick target, the impinging projectile energy decreases as it penetrates into the target thickness, thus the energy variation against target thickness, and the related variation of the cross section versus energy, must be considered.

The parameters that have an impact on the production yield (TTY) are the beam intensity, the irradiation time and the beam energy range: the beam intensity is limited by the maximum beam current available by the accelerator and also by the thermal-mechanical main features associated to the targetry; the irradiation time can be increased, keeping in mind that the SF trend keeps linear until the irradiation time remains below one T1/2; the projectile energy range can be adapted to exploit the maximum cross section value, considering the limitation due to the coproduction of contaminants, by adjusting the incident energy and the target thickness. The presence of contaminants, especially radionuclides with close to or longer half-life than the desired radionuclide, affects the purity of the final product and may cause a dose increase to the patient.

To limit as much as possible the reaction routes which may be opened, and thus the coproduction of undesired radionuclides, it is often necessary to use expensive isotopically enriched materials. Even considering the ideal case of a fully monoisotopic target, it is foreseen the coproduction of isotopic contaminants, depending upon the beam energy range chosen. A good knowledge of production cross sections for all the occurring nuclear reaction routes is therefore a key point that has to be carefully considered. The production cross section of the concerned radionuclide, as well as those of main contaminants, the optimal irradiation parameters may be at last selected, i.e. the irradiation time and beam energy range, in order to ensure the achievement of the best final product purity given by the Specific Activity AS [Bq⋅g−1], the Radio Nuclidic Purity RNP [%] and the Isotopic Purity IP [%] parameters [218].

1.3.1 Experimental details on a nuclear cross section measurement

The use of a single thin homogeneous target foil, followed by a precise Faraday cup to measure the hitting beam current, is the best method to obtain an accurate measurement of a specific nuclear cross section. However, due to the limited access to beam time it is often preferred to use the well-known stacked-foils technique that allows, by the simultaneous bombardment of patterns composed of target and degrader foils, to get the experimental determination of some cross section values at different beam energies during the same irradiation run. In order to control the beam energy loss through the target stack, it is desirable to insert in the structure at least two monitor foils of an element for which the production cross section of a given reaction route is well known and that acts as a reference. Particular attention has also to be paid to the material used in the stack both for degrader and monitor foils, since the recoil effect, i.e. when some atoms jump out of one foil and are trapped in the following one, may also cause some additional interferences in the γ-spectrometry acquisitions.

In addition to the aforementioned parameters that have to be taken under control for a precise nuclear cross section measurement, it is important to remind the role of the target thickness (homogeneity and purity), the beam stability during the irradiation run and the beam energy precision (the possibility to use a tunable energy accelerator is favourable), the detector calibration (energy and efficiency) and the possible interferences in the emitted γ-lines or in the decay relations among metastable/ground state or parent/daughter radionuclides.

1.3.2 Theoretical aspects on nuclear cross sections assessment

Theoretical description of nuclear reactions, occurring below 100 MeV/amu, imply many different interaction processes, such as the compound-nucleus reaction, the direct nuclear reaction, and the pre-equilibrium nuclear reactions [19]. Several nuclear reaction codes are available that include models that implement these different nuclear reaction mechanisms between a target nucleus and a hitting particle. The most used ones are TALYS [20, 21], EMPIRE [22], FLUKA [23, 24] and MCNPX [25]. They are usually exploited to estimate the trend contributions for those nuclear reaction routes, whose cross sections data are not measured yet. The IAEA tool ISOTOPIA [26] is instead based on the IAEA data as well as on the TENDL library [27], a nuclear database built on the TALYS code. TALYS is used to simulate nuclear reactions involving protons, neutrons, deuterons, photons, tritons, 3He and α-particles, in the 1 keV to 200 MeV energy range and covers target nuclides of mass 12 and heavier. TALYS includes a large number of different models and some of them are invoked in calculation by default. Concerning compound reaction contributions, TALYS 1.9, the last version available to date, performs default calculations in the Hauser–Feshbach approach with Moldauer width fluctuation corrections. Koning and Delaroche local parametrization for the optical model is used with different models to take into account direct reaction contributions: Distorted-Wave Born Approximation (DWBA) Coupled-channels (rotational and vibrational approaches). Since TALYS has been used in many works to benchmark the experimental determination of nuclear cross sections for many radionuclides of interest in medicine, we mainly refer to this code in this review study. We focused on TENDL-2021 which is based on the last version of the TALYS code. However, in some cases the TENDL-2021 cross sections are different from the earlier versions (and in few cases less in agreement with available data), underlining the need of additional work, both for new experimental data to constrain the code and in the optimal identification of the TALYS parameters that better describe the nuclear reactions for this kind of applications [28].

2 Charged-particles induced reactions

Nowadays, most accelerator-based radionuclides are produced using proton beams. This is mostly linked to the fact that there is a large installed network of low-energy cyclotrons, often called Small Medical Cyclotron (SMC) [29], and that protons can be accelerated as negative ions that are extracted with nearly 100% efficiency using stripper foils. Alpha particles may instead only be accelerated as positive ions and the extraction process is more challenging. With the larger availability of both medium and high energy accelerators, new linear accelerator like SPIRAL2 [30] or the one available at SOREQ [31] providing p, d, α-particles beams with mA intensities, and multiparticle cyclotrons allowing access to high energy deuterons and α particles beams, the production routes for established as well as emerging radionuclides may thus be re-investigated. In all cases, by changing the projectile type and/or its energy and/or the target material, it is possible to adapt the production yield and the profile of contaminants [32]. In the following examples, we will present some cases showing that:

  1. the quality of the final product strongly depends on the chosen target/projectile/energy parameters set (67Cu and 47Sc cases);

  2. the deuterons-based production route may sometimes lead to a different impurity profile (67Cu and 89Zr examples) or be more effective than the protons-based one (103Pd and 186Re case). This latter property is basically due to the more complex deuteron-induced interaction process with respect to the proton one (i.e. involving the breakup mechanism, direct reaction stripping, and pre-equilibrium and compound-nucleus) that have been studied in different former works which details may be found in [33], [34], [35]. Because of the weak binding energy of deuterons, Bd = 2.224 MeV, a more complex interaction process indeed occurs, that involves different reaction routes started by neutrons and protons following the deuteron breakup that enhance the production route. Moreover, a reliable description of the deuteron-nucleus interaction is a good test for the quality of the reaction mechanism modeling, as well as the evaluation of the nuclear data;

  3. α-particle beams may allow to bypass the limitations occurring when using proton beams (97Ru and 211At examples). A complete description of potential of alpha beam can be found in [14].

Table 1 shows the decay characteristics, extracted from the NuDat 3.0 database [36], of the medical radionuclides considered in this review. When available, the recommended IAEA curves [37], [38], [39] will be used instead of the available data sets [40] for simplicity and readability.

Table 1:

Main decay data of the radionuclides of interest [36].

RN Half-life Main γ-ray energy, intensity [keV] (%) Mean β + energy, intensity [keV] (%) Mean βenergy, intensity [keV] (%) Auger and IC electrons Main α-particle energy, intensity [keV] (%)
67Cu 61.83 h 184.577 (48.7) 141 (100) Yes
47Sc 3.3492 d 159.381 (68.3) 162 (100) Yes
89Zr 78.41 h 909.15 (99.04) 396 (22.74) Yes
103Pd 16.991 d Yes
186gRe 3.7183 d 137.157 (9.47) 346.7 (92.59) Yes
97Ru 2.83 d 215.70 (85.62) Yes
324.49 (10.79)
211At 7.214 h 687.0 (0.261) Yes 5869.5 (41.8)

2.1 67Cu

67Cu has a half-life of 61.83 h and it is emitting β and γ radiation [36]. The energy of β particles is appropriate for therapy (141 keV as mean energy, corresponding to about 200–300 μm range in soft tissue), while the 185 keV photons are suitable for pre-therapy low dose imaging (SPECT or SPECT/CT). These physical characteristics allow the use of 67Cu for both therapy and associated diagnostic applications, thus making 67Cu a promising theranostic radionuclide. It can be also used as a therapeutic counterpart of the 64Cu (12.7 h half-life and β+ emitter), a PET radionuclide [5, 41, 42]. Production techniques for 64Cu are well known and are usually based on the 64Ni(p,n)64Cu and 64Ni(d,2n)64Cu reactions routes [43], even if there are other possibilities [43, 44].

The use of 67Cu has been prevented by the lack of regular availability in enough amounts for preclinical and clinical studies, although it is possible to produce it through many production routes [9, 45, 46]. There is currently not a clear consensus about the best nuclear reaction route to be used for a massive production, due to the impact of the coproduced isotopic 64Cu that occurs with some specific routes [47]. Indeed, the presence of the 64Cu annihilation photons affects the total dose received by the patient and the staff, while the emitted Auger electrons, the positron and the electrons release their energy close to the decay point, adding their contribution to the dose in tissues.

Nuclear data are therefore important to help in defining benefits and drawbacks associated with each of these production routes. Among the feasible ones are the following:

  1. 68Zn(p,2p): this production method has quite a low cross section (maximum value of around 10 mb) [40] and requires intermediate energy proton-beams (30 < E < 100 MeV), although it can be exploited also at higher energies [48], [49], [50], [51], [52], [53]. In order to limit the coproduction of other Cu-radionuclides, which directly affects the radionuclidic purity of the final product, the use of enriched 68Zn targets is mandatory, as well as the recycling of the target material to make this production route affordable. Among the variety of radionuclides produced during the bombardment of a zinc target, 67Ga (half-life 3.2617 d) is particularly relevant: it presents the same γ-lines of 67Cu since they both decay into 67Zn [36]. Moreover, they have a similar half-life, and therefore it is not possible to infer the precise activity determination of one radionuclide waiting for the decay of the other one. For these reasons a radiochemical procedure, aimed at the separation of copper from gallium elements, is thus mandatory to obtain a precise cross section for 67Cu production [49, 54]. The separation procedure, as well as the use of different target materials (natural or enriched), selected monitor reactions or not up-to-date decay data, could explain the large discrepancies of the published data. The measurement carried out at the ARRONAX facility led to an estimated difference on the 67Cu production yield of up to 15% in the 70–35 MeV energy range [54]. This difference has a direct impact on the planning of sustainable production of 67Cu for medical purposes. It should also be outlined that with this production route a large amount of 64Cu is coproduced, as indicated by the 68Zn(p,x)64Cu cross section recommended by the IAEA up to 100 MeV [37]. 64Cu can be limited in the final product by waiting for its decay up to the desired value of the 67Cu radionuclidic purity, however loosing part of the 67Cu activity.

  2. 70Zn(p,α): this nuclear reaction, already measured up to 35 MeV by Levkovskij (1991) [50] and Kastleiner et al. (1999) [55], has a maximum cross section value of 15 mb at about 15 MeV. This production route can allow the supply of pure 67Cu as there is no coproduction of 64Cu below Ethr = 23.8 MeV (threshold energy associated with 64Cu production). Considering the low cross section value this production route provides quite a low yield, i.e. 5.75 MBq/µAh for the 30–10 MeV energy range (corresponding to a 1.79 mm thick target of 100% enriched 70Zn). Also in this case, enriched target material and recycling are mandatory.

  3. 70Zn(p,x): The use of 70Zn targets at proton energies higher than 35 MeV allows to increase the 67Cu yield (Figure 1 left), limiting the 64Cu coproduction in comparison to the use of 68Zn targets [56]. The 67Cu production cross section reaches a value around 22 mb at 70 MeV, thus it is almost a double value than the recommended cross section by the IAEA, based on 68Zn target. In addition to that, the 64Cu coproduction occurring with 70Zn targets shows a decreasing trend versus the increasing energy, while the opposite trend can be noted when using 68Zn targets (Figure 1 right). TENDL library values [27] seem to overestimate the 70Zn(p,x)67Cu reaction, as well as the 68Zn(p,2p)67Cu cross section (Figure 1 left). On the other hand, TENDL results of the 68Zn(p,x)64Cu cross section slightly underestimate IAEA recommended values and show an energy shift of about 5 MeV for the peak below 30 MeV (Figure 1 right); the trend of the 70Zn(p,x)67Cu cross section is well described by the TENDL-data, but there is an underestimation of the experimental values by about a factor of 2.

  4. 70Zn(d,x): this nuclear reaction has already been measured in 2012 [57] and in 2021 [58] up to 29 MeV. From the most recent data it was possible to identify the cross section peak value associated with this nuclear reaction (about 30 mb at 23 MeV). The comparison between the cross sections data obtained with 70Zn as target material for proton or deuteron beams (Figure 2) shows that the deuteron production route is more efficient than the one using protons. Furthermore, since the threshold associated with 64Cu production is 26.5 MeV, this isotope is not produced in significant amount up to 30 MeV, allowing for a “pure” 67Cu production. The preferred energy range through this route is thus 16–26 MeV, that corresponds to a 70Zn thickness of 576 µm. Considering this energy range, 1 µA beam intensity, 1 h of irradiation time, and a target purity of 97.5%, the estimated production yield is 6.2 MBq [58].

  5. 64Ni(α,p): this nuclear reaction has been measured since the 1960s up to 50 MeV [50, 5962] and it presents the maximum value of about 38 mb at 22 MeV. Since the threshold for 64Cu production is 23.7 MeV, this radioisotope is not produced in large amount up to 30 MeV allowing, also in this case, a “pure” production of 67Cu [63]. The main advantage of this production route is the fact that enriched 64Ni target (natural abundance equal to 0.9255%) is well mastered as it is the target used for 64Cu production. A pure 67Cu production requires the use of enriched 64Ni and recycling, making the enrichment level of the target material a crucial aspect (currently it is commercially available with an enrichment level >99%).

Figure 1: 

67Cu (left) and 64Cu (right) production cross sections induced by proton-beams on 68Zn and 70Zn targets.
Figure 1:

67Cu (left) and 64Cu (right) production cross sections induced by proton-beams on 68Zn and 70Zn targets.

Figure 2: 

67Cu production cross sections induced by deuteron and proton beams on 70Zn targets.
Figure 2:

67Cu production cross sections induced by deuteron and proton beams on 70Zn targets.

To compare the charged-particles induced nuclear reactions, Table 2 presents the 67Cu (and 64Cu) production yields calculated using the IAEA tool ISOTOPIA [26], assuming 100% enriched materials and the same irradiation conditions (67Cu SF = 24%, 64Cu SF = 73%) considering proton, deuteron and α-beams on 70Zn, 68Zn, and 64Ni targets [61].

Table 2:

67Cu and 64Cu production yields obtained by using proton, deuteron and α-beams on 70Zn, 68Zn, and 64Ni enriched target materials assuming I = 30 µA and Tirr = 24 h.

Beam Target Energy range (MeV) Thickness (mm) 67Cu at EOB (GBq) 64Cu at EOB (GBq)
Protons 70Zn 25–10 1.22 3.0
68Zn 70–35 6.43 17.5 150
70Zn 68–45 4.61 22.2 140
Deuterons 70Zn 26–13 0.68 4.3
Alpha 64Ni 30–0 0.15 1.0

The values reported in Table 2 show that with a hypothetical fully enriched target material (68/70Zn or 64Ni) the most convenient route to obtain 67Cu (without 64Cu coproduction) is by using deuteron beams and 70Zn targets. The final 67Cu quality using this route will be close to that obtained by photo-production [64, 65]. If some 64Cu coproduction is acceptable for clinical application, the 68Zn(p,2p)67Cu reaction seems to be a better option since it provides a larger 67Cu yield in comparison with the 70Zn(d,x)67Cu route mostly because more intense proton beams can be available (hundreds of µA as compared to tens of µA for deuterons). With the same motivation, also the high-energy 70Zn(p,x)67Cu route seems to be interesting. The α-beam production route may benefit soon from the newly available multiparticle 30 MeV accelerators providing tens of µA. The first two machines have been installed in Europe (Jülich and Warsaw) and some others are available in Japan. In the future, linear accelerators that can provide very intense deuteron and α-beam (mA range) are soon foreseen, however in this case the major challenge will be the design of specific targets able to withstand such high currents.

2.2 47Sc

47Sc (half-life 3.3492 d) is one of the radionuclides of interest in theranostic applications thanks to its β and γ-radiation (β mean energy 162 keV, 100% intensity; Eγ = 159.381 keV, 68.3% intensity) which makes it suitable for both therapeutic and diagnostic purposes [41, 42]. The interest in 47Sc is also due to the possibility to pair it with a β+ emitter isotope, such as 44gSc and 43Sc, allowing to carry out also PET imaging [66]. 47Sc can be produced via different nuclear reaction routes by using cyclotrons, nuclear reactors, and electron linear accelerators [5]; moreover, 47Sc may be produced either directly or by the decay of its parent radionuclide, 47Ca, as shown in Table 3. Particular care must be paid to the other Sc-isotopes produced during irradiation, since they cannot be chemically separated from 47Sc. Among the Sc-isotopic contaminants, the most critical one is 46Sc, due to its long half-life (half-life 83.79 d) and γ emissions (889.277 keV with 99.9840% intensity and 1120.545 keV with 99.9870% intensity).

Table 3:

Direct and indirect reactions to produce 47Sc with the nuclear reactions induced by charged particles or neutrons.

Target Particle accelerator Nuclear reactor
p d α n
Direct reactions Ti 50Ti(p,α)47Sc 50Ti(d,αn)47Sc 47Ti(n,p)47Sc (fast neutrons)
49Ti(p,2pn)47Sc 49Ti(d,α)47Sc
48Ti(p,2p)47Sc 48Ti(d,2pn)47Sc
Ca 48Ca(p,2n)47Sc 48Ca(d,3n)47Sc 44Ca(α,p)47Sc
V 51V(p,αp)47Sc 51V(d,x)47Sc
Indirect reactions Ti 50Ti(p,3pn)47Ca→47Sc 50Ti(d,αp)47Ca→47Sc
V 51V(p,x)47Ca→47Sc 51V(d,x)47Ca→47Sc
Ca 48Ca(p,pn)47Ca→47Sc 48Ca(d,p2n)47Ca→47Sc 46Ca(n,γ)47Ca→47Sc (thermal neutrons)

Considering the proton induced-reactions, the:

  1. natTi(p,x)47Sc cross section has been widely studied by many research groups, but no energy range has been found in which the 47Sc is produced without 46Sc. Considering the composition of natTi (natural abundances: 50Ti 5.18%, 49Ti 5.41%, 48Ti 73.72%, 47Ti 7.44%, and 46Ti 8.25%) it is not possible to extract from the whole cross sections the contribution of each titanium isotope to the production of the specific radionuclides of interest. Since no data are available for the 49Ti(p,x)47Sc cross section and only a few data sets are published for the 50Ti(p,x)47Sc [45] and the 48Ti(p,2p)47Sc [50, 67, 68] reactions, both studied up to 85 MeV, it will be desirable to add new experimental data in order to evaluate if one of these production routes can be competitive.

  2. 48Ca(p,2n)47Sc excitation function was measured in 2019 up to 30 MeV [69] reaching a value of 1100 mb at about 18 MeV. However, it must be taken into account that, despite the large cross section value, the natural abundance of 48Ca is only 0.187%, thus making this production route feasible with highly-enriched targets only (enrichment levels available up to 97%), that are anyway very expensive (recycling is mandatory).

  3. natV(p,x)47Sc cross section has been measured by many authors [28, 50, 7074] up to 200 MeV, reaching a maximum value of about 12 mb at 34 MeV and for energies higher than 80 MeV. A recent work reported new experimental data for 47Sc and contaminants coproduction using natV targets, compared with theoretical estimations obtained by varying the level densities using the TALYS code [28]. Considering natV targets it is possible to limit the coproduction of the 46Sc by using the energy range 35–19 MeV. The theoretical 47/46Sc production estimates based on the experimental results and the well-known DOTA-folate conjugate cm10 ([47Sc]-cm10) biodistribution, allowed to evaluate the dose increase due to the presence of the 46Sc contaminant [75]. The calculations showed that for Ep < 35 MeV and specific irradiation conditions considered, the effective Dose Increase (DI) due to the presence of contaminants was maintained within the 10% limit required for clinical use [75, 76]. However, to limit the presence of the 46Sc contaminant, the calculated 47Sc yield in the 35–19 MeV energy range is rather low, i.e. 0.1 GBq (irradiation conditions: 1 µA proton beams and 24 h of irradiation time), still suitable for preclinical studies [75].

Regarding the indirect reactions induced by protons to obtain the 47Ca → 47Sc precursor system, only few data are available in the international database [40]. The 51V(p,x)47Ca cross section was measured up to 250 MeV with a maximum value of about 0.2 mb making this route unfeasible [69]. No experimental data are present for the 50Ti(p,x)47Ca and the 49Ti(p,x)47Ca nuclear reactions, whose threshold energies are 24.5 and 21.2 MeV, respectively. On the other hand, the trend of the 48Ca(p,x)47Ca cross section was measured up to 19 MeV in 2019 [69], showing a maximum value of about 240 mb at 17 MeV. The low natural abundance of the target material (0.187%) has to be reminded that would make this route very expensive.

Considering the deuteron-induced reactions to produce 47Sc, the:

  1. natTi(d,x)47Sc excitation function has been measured by several authors [77], [78], [79], [80], [81], [82], [83], [84], showing a good agreement in the increasing trend of the reaction cross section from low energy up to 50 MeV. Also the co-production of 46Sc has been measured by different research teams and it is not possible to indicate a deuteron energy range where there is a pure 47Sc production [77], [78], [79], [80], [81], [82], [83], [84], [85], [86].

  2. 50Ti(d,αn)47Sc cross section was measured in 1964 [87], showing an increasing trend up to about 65 mb at 17.5 MeV; unfortunately, there are no data on the coproduction of 46Sc, whose production threshold energy is 4.6 MeV.

  3. 49Ti(d,α)47Sc excitation function was measured in the same experimental campaign in 1964 [87], depicting a peak of about 45 mb at around 10 MeV. In this case, the 46Sc coproduction was measured in the same energy range (7–20 MeV), obtaining an increasing trend with a plateau value of about 25 mb from 17.5 MeV up to 20 MeV; the lowest 49Ti(d,αn)46Sc cross section value is at 12 MeV, amounting to ca. 7 mb.

  4. 48Ti(d,x)47Sc cross section has never been measured (Ethr = 6.2 MeV). In the 1960s the 48Ti(d,α)46Sc excitation function was measured by different authors [87], [88], [89], giving a peak of 40 mb at around 12 MeV. It can be noted that there is a large discrepancy in the low energy region, around 7 MeV, with the value reported by Hall et al. [89] very close to 0 mb and the value measured by Chen et al. [87] around 24 mb; considering the agreement in the values reported by Chen et al. and Anders et al. [88], one may conclude that the 24 mb value is more reliable.

  5. 47Ti(d,2p)47Sc excitation function was also measured in 1964 by Chen et al. [87], showing an increasing trend from 10 MeV up to 20 MeV, with a maximum value of ca. 45 mb. There are no data regarding the 46Sc coproduction, whose threshold energy is 5.2 MeV.

  6. 48Ca(d,3n)47Sc and 46Ca(d,n)47Sc cross sections were not measured, and also not for 46Sc coproduction; the threshold energies are respectively 11.4 and 22.5 MeV for 47Sc and 46Sc production with 48Ca targets, 0 and 4.8 MeV in case of 46Ca targets.

  7. natV(d,x)47Sc cross section has been measured up to 90 MeV by three research teams, with agreeing results [90], [91], [92]. The cross section starts at 25 MeV and it reaches the maximum value of about 30 mb at ca. 40 MeV, then it decreases to 20 mb at 60 MeV with almost a flat trend up to the maximum energy. Unfortunately, the co-production of 46Sc can be avoided only for deuteron energies <30 MeV. Below 40 MeV there is a low co-production of 46Sc, since its production cross section is still at 5 mb, but it rapidly increases up to about 50 mb at ca. 55 MeV, keeping a quite flat trend up to 90 MeV.

Regarding the indirect reactions induced by deuterons to obtain the 47Ca, it is possible to irradiate natV targets: however, the production cross section is quite low (<0.4 mb) in the entire 30–90 MeV energy range investigated [91, 92].

Considering the α-induced reactions, the:

  1. 44Ca(α,p)47Sc cross section has been measured up to 45 MeV reaching a maximum value for 47Sc production of about 120 mb at 14 MeV [50]; the same author also measured the coproduction of 46Sc, finding a peak of about 400 mb at around 25–30 MeV. Although the natural abundance of 44Ca is only 2.086%, the advantage in the use of α-beams lies in the short range of α particles in Ca targets, allowing the use of a limited amount of enriched 44Ca target material, compared to the use of proton and deuteron beams. The work published by Minegishi et al. [93] also reports the 47Sc yield of about 11 MBq at the end of preparation (approximately 1.5 h from the EOB), obtained by irradiating a [44Ca]CaO (44Ca = 97.0 atom%, 40Ca = 2.89 atom%) target of 200 mg in the energy range 28→0 MeV at 10 eμA, for 2 h irradiation. To obtain pure 47Sc it is necessary to take into account the expected large coproduction of 46Sc, not reported in the work by Minegishi et al. [93].

  2. 46Ca(α,t)47Sc cross sections are not known [40]; the threshold energies are respectively 12.3 and 23.9 MeV for 47Sc and 46Sc production.

In conclusion, some charged-particle induced reactions need to be measured to verify if they are feasible as 47Sc production routes, e.g. 48/49/50Ti(p,x)47Sc, 47Ca → 47Sc, 47/48/49/50Ti(d,x)47Sc, 46Ca/48Ca(d,x)47Sc and 46Ca(α,x). From all the data available it turns out that the only ways to get 47Sc without 46Sc using light charged particle induced reactions lead to low production yield, not suitable for clinical use. It is thus necessary to study how to add a mass separation step to remove 46Sc. Also in this case further cross section measurements will be needed to identify a precise impurity profile associated with each possible production route and it will be necessary to carefully look at mass separation technique, presumably coupled to laser ionization to be able to extract pure 47Sc with high efficiency [94, 95].

2.3 89Zr

Thanks to its nuclear characteristics (T1/2 = 78.41 h, 22.3% positron emission with a maximum energy of 900 keV), zirconium-89 (89Zr) is a very promising radionuclide for immuno-PET [96]. Different experimental results obtained to produce zirconium-89 from a 89Y target [97] may be compared by using both proton and deuteron beams [50]. The proton thick target yield is higher up to 26.5 MeV leading to higher production yield, whereas above 26.5 MeV the achievable yield with protons is lower than that obtained with deuterons [96, 98]. At the same time, a lower amount of radionuclidic impurities is produced by deuteron irradiation. For example, to keep a radionuclidic purity of 99.9%, it is possible to use a higher beam energy for deuterons (20.5 MeV) than for protons (16.2 MeV) which turns out in about 10% higher production yield for deuteron.

It is also possible to investigate other routes, such as the reactions 87,88Sr(α,xn)89Zr [50] that can be the object of further investigation as they seem competitive in the production of 89Zr with possibly high radionuclidic purity.

2.4 103Pd

103Pd (T1/2 = 16.991 d) decays almost exclusively (99.90%) by electron capture (EC) to 103mRh (T1/2 = 56.12 min) which de-excites through internal transition (IT) [36]. As a result of these processes (EC and IT) Auger-electrons and X-rays are emitted which are ideally suited for cancer therapy. Considering also the de-excitation of the “daughter” nuclide 103mRh, every 100 decays of 103Pd are accompanied by the emission of about 263 Auger electrons, 188 low-energy conversion electrons and 97 X-rays. A comparison between the IAEA curve for the deuteron production and the IAEA curve for the proton production of 103Pd [99] shows that the yields are comparable up to 12 MeV. For higher particle energies the achievable thick-target yield with deuterons is higher.

There are only two works reporting the production of 103Pd by particles other than protons and deuterons [100], [101], [102]. Some of these reactions, mainly 101Ru(α,2n)103Pd and 103Rh(3He,x)103Pd, may be worth the effort for further investigation in order to evaluate the achievable specific activity and the radionuclidic purities.

2.5 186gRe

186gRe is a β/γ emitter radionuclide with a half-life of 90.64 h. The β end-point energies of 1.07 and 0.93 MeV suggest that this radionuclide is a good candidate for therapy of cancers with small tumour dimensions (from few millimetres to a few centimetres) [103]. Moreover, its γ-emission at 137.15 keV (very close to that of 99mTc) is in the energy range suitable for SPECT imaging (i.e., sufficiently high energy to penetrate the body and sufficiently low to be collimated by thin collimators and detected by thin detectors) [41, 42].

Very high specific activity 186gRe can be produced by either proton [104], [105], [106], [107], [108], [109] or deuteron [77, 110116] cyclotron irradiation [117], provided an enriched target is used. It is possible to compare the experimental results obtained to produce rhenium-186g from a natW target using proton and deuteron beams. The cross section values for the deuteron beams are considerably greater than for the proton beams. The maximum value that is possible to obtain with deuterons is almost 9 times greater than the maximum value for the protons. This effect is also confirmed by the study of thick target yield [118]. It is possible to compare the integrated thin target yields of 186gRe by using proton or deuteron beam: the two curves are coincident till energy of almost 8 MeV. From this energy up to 9 MeV, the yield of the proton bombardment is slightly larger than the deuteron one but starting from 9 MeV the deuteron yield grows much faster than that of the proton irradiation.

Even if there is a very short energy range in which proton irradiation is competitive with the deuteron one, there is no reason to prefer proton beams. In fact, the advantage of using deuterons over protons for the preparation of 186gRe is double: more 186gRe is formed and less 186W is needed for the target, due to larger -dE/dx in the case of deuterons, by a factor of 4. This lower amount of target material is advantageous both to lower production cost and to simplify the dissolution of the target and its separation from the produced 186gRe, with advantages also for waste and radioprotection purposes. This makes the deuteron route at facilities with medium-size cyclotrons the best choice for 186gRe production.

It is also possible to investigate other routes [119], [120], [121] among which the 192Os(p,α3n)186gRe [119] and 186W(α,x)186gRe [120, 121] reactions may be of some interest. However, there is a high probability that other rhenium isotopes are produced and will affect the specific activity and the radionuclidic purity of the final product.

2.6 97Ru

The radionuclide 97Ru, with a half-life of T1/2 = 2.83 d, emits low-energy high-intensity γ lines (215.7 keV with 85.8% intensity and 324.5 keV with 10.8%) which have favourable characteristics for SPECT imaging. This can be beneficial to select a patient that may respond to new chemotherapy agents developed with ruthenium [122]. It decays by electron capture (EC) leading to Auger emission that can be used for Auger therapy. It can form a theranostic matched pair with 103Ru (T1/2 = 39.26 d) that decays to the short-lived Auger emitter 103mRh (T1/2 = 56.12 min), a promising γ-free therapeutic agent.

Production of 97Ru can be done by irradiation of 99Tc with protons [123]. Unfortunately, Tc as a radioelement (T1/2 = 2.111⋅105 y) is not easily available and it requires a dedicated infrastructure to be used as target material. Other reactions with proton-beams can be measured [124], [125], [126], but it seems more attractive to explore the use of an α particle beam coupled to a molybdenum target that is easily available as natural molybdenum or as enriched material [127], [128], [129]. Recently, new cross section values [130] were measured toward higher energy in coherence with commercially available cyclotrons [15] which are able to deliver α-beam up to 70 MeV. These data allow the optimization of natMo(⍺,x)97Ru production route and constrain the nuclear codes to explore the possibility to use enriched Mo targets. Figure 3 shows recent data reported in the literature for the cross sections of natMo(⍺,x) reactions to produce 97Ru [123, 130132].

Figure 3: 
Measured cross section for natMo(⍺,x)97Ru reaction [130] compared with data available in the literature [40, 131, 132].
Figure 3:

Measured cross section for natMo(⍺,x)97Ru reaction [130] compared with data available in the literature [40, 131, 132].

A plateau is reached above 20 MeV coming from the fact that natMo is a mixture of six stable isotopes with comparable abundance. If enriched 95Mo or 96Mo targets are used instead, one can increase the production by a factor of five–six thanks to the natural abundances of these isotopes, that are respectively 15.84 and 16.67%, and considering that the beam energy can be defined adequately to favour the (α,2n) and (α,3n) reactions. Using a natMo target with a thickness of 100 mg/cm2 and a 30 MeV beam energy, 3.5 MBq/µAh can be obtained. This example shows the benefit of having an α beam to allow for an alternative route when the target material is not easily available (see also [14]).

2.7 211At

211At (Z = 85) is an α emitter that is promising for targeted α therapy. It has a half-life T1/2 = 7.214 h and it emits one α particle per decay, either directly decaying to 207Bi (41.80%, Eα = 5.869 MeV) or indirectly through EC (58.2%) to 211Po, that quickly (T1/2 = 0.516 s) decays to 207Pb (Eα = 7.3695 MeV). In the emitted radiation by 211At there are also X-rays that can be used for imaging purpose. As the heavier stable element in the radionuclide chart is 209Bi (Z = 83) and there is no long lived radionuclide in the close vicinity of 211At, it is not possible to use low or medium energy proton or deuteron beams to produce it. The only possibility is to rely on an α particles beam impinging on a bismuth target (Z = 83). Bismuth is by chance monoisotopic, which makes target fabrication not expensive and easy to manufacture by evaporation under vacuum.

The energy threshold for 211At production through the (α,2n) reaction is 20.7 MeV. In Figure 4, the family curves of integrated thick target Yields Y(E,ΔE) and the loci of the maxima, corresponding to optimal irradiation conditions for production, are presented. From these curves, it is clear that increasing the incident energy allows increasing the 211At production. Unfortunately, 210At (T1/2 = 8.1 h) can also be produced by irradiation of a bismuth target with an alpha beam starting at 28.613 MeV (energy threshold of this reaction). This radionuclide must be avoided as much as possible, as it decays to the bone seeker 210Po (T1/2 = 138 d) that decays by α emission and it is highly radiotoxic. One possibility is to restrict the beam energy below the energy threshold of 210At production but this will limit the production yield of 211At at the same time. The rise of the 210At production cross section is slow and there is room to optimize the irradiation parameters if one can define the acceptable limit of 210At in the final 211At product. This point is of fairly high importance as beam delivered by accelerators have some energy dispersion. In Table 4 the measured 210At/211At activity ratio are presented [133], [134], [135], showing how the ratio evolves as a function of the beam energy close to 210At production energy threshold. From these data, it is clear how the choice of an incident energy of 28.8 MeV, slightly higher than the threshold energy (28.613 MeV) for the 209Bi(α,3n)210At reaction, allows to produce limited quantities of the 210At radionuclide impurity, remaining below 1%, considered as a limit value.

Figure 4: 
Integrated thick target yield for 211At as a function of energy and energy loss into the target, with the loci of maxima corresponding to the couples (E,ΔE) for optimal irradiation conditions to produce the radionuclide with higher as possible yield, radionuclidic purity and specific activity [134].
Figure 4:

Integrated thick target yield for 211At as a function of energy and energy loss into the target, with the loci of maxima corresponding to the couples (E,ΔE) for optimal irradiation conditions to produce the radionuclide with higher as possible yield, radionuclidic purity and specific activity [134].

Table 4:

Experimental activity 210At/211At ratio [134].

Beam energy (MeV) 27.6 28.6 28.8a 29.1 29.6 30.1 32.8a
210At/211At (%) <4.4E-4 <0.01 0.001 0.023 0.18 0.7 7.4
  1. The data (a) are reported in [134, 135].

More precise cross section values close to the 210At threshold may help optimize production yield as a function of 211At purity. In parallel, some toxicology studies on the impact of 210At content in the final 211At product are needed to get a consensus on the acceptable level of 210At for medical application.

3 Discussion and conclusion

Through the radionuclides discussed in this review (67Cu, 47Sc, 89Zr, 103Pd, 186gRe, 97Ru, 211At) it has been high-lighted how the accelerated beam type and/or its energy and/or the target material have a direct impact on the production yield, the purity and the contaminants profile of the final product to be used for radiopharmaceuticals labelling procedure. Since the quality of the final product strongly depends on the chosen target/projectile/energy parameters set, the accurate knowledge of the production cross section of the desired radionuclide and related contaminants is the key point for the irradiation parameters optimization. Considering the frequently need of using isotope-enriched materials to limit as much as possible the coproduction of contaminants, the possibility to recover and reuse the irradiated target materials is an additional key aspect for the economical sustainability of the production cycle. For this reason, it is also useful to study the coproduction of radioactive isotopes (especially the long-lived ones) that may affect the recovery process.

An interesting example of this work is the 67Cu case, whose production is usually based on the well-known (p,2p) reaction on 68Zn targets; however, the high-energy 70Zn(p,x)67Cu route seems to be an interesting option and even a favourable route above 56 MeV, not only for the higher 67Cu production yield (almost double), but also for the lower 64Cu coproduction. From a practical point of view, it has to be outlined that the price of the enriched 68Zn and 70Zn material differs by a factor of about four, considering that the natural abundances of these zinc isotopes are 18.45 and 0.61%, respectively. The expenses of the enriched 68/70Zn isotopes can be amortised considering the possibility to recover and reuse the irradiated material, to manufacture new targets for a defined number of production cycles. In this case, it is important to know the production cross sections of the long-lived 65Zn isotope (243.93 d half-life), to properly define the methods for the recovery process considering the activation of the material, minimizing as much as possible the dose imparted to the operator. With the development of high-energy high-intensity deuteron beams, the 70Zn(d,x) production route will become attractive as it allows to obtain high-purity 67Cu, as provided through the use of e-LINAC exploiting the 68Zn(γ,x)67Cu reaction [65].

As previously shown, the use of deuteron beams instead of the proton ones can sometimes be more effective (as for examples the 103Pd and 186Re case) or lead to a different impurity profile (e.g. the 67Cu and 89Zr cases). The criticality of these production routes is linked to the practical availability of accelerators with deuteron beams providing beam energies larger than 9 MeV and reasonable intensity (≥50 μA). On the other hand, considering radionuclides with a mid half-life as for the 186gRe (3.7186 d) and 89Zr (78.41 h) cases, nothing prevents to produce in centralized facilities with medium-size cyclotrons and ship them to the clinical centres over long distances. Also the increasing availability of intense α-beams may allow to bypass the limitations occurring when using protons or deuterons: this is the case of 97Ru and 211At production, and the possibility to investigate the new route for 186gRe based on the 186W(α,x)186gRe cross section. On the other hand, also considering proton beams some interesting production routes have still to be investigated: as examples it can be reminded the 47Sc production and the use of enriched Ti-targets, such as 49Ti and 50Ti.

A paradigmatic case is linked to the supply of the medically relevant Tb-isotopes, i.e. 149Tb, 152Tb, 155Tb and 161Tb [66]. These isotopes can be produced with different projectile/target/energy ranges, obtaining different yields and contaminant profiles; among the possible nuclear reactions to be exploited, some of them have still to be investigated. For the 155Tb case [136], [137], [138], [139], [140], [141], [142], the main routes are based on the 155Gd(p,n) and 156Gd(p,2n) reactions, as outlined by a recent work [143], finding a purer 155Tb with the (p,n) reaction and a higher yield with the (p,2n) one. On the other hand, 155Tb can be also produced with a 155Dy→155Tb precursor system, exploiting the 155Dy decay (9.9 h half-life). In this case, 155Dy can be produced with high-energy proton beams and natural Tb-targets, using the 159Tb(p,5n)155Dy reaction [138, 144, 145]. Particular attention has to be paid to the coproduction of Dy-isotopes that decay to Tb and that may affect the final 155Tb purity: the irradiation, decay, separation and elution times have thus to be carefully studied to maximize the 155Tb radionuclidic purity. The advantage of the 159Tb(p,5n)155Dy→155Tb route relies on the use of natural targets, even if the separation and purification chemistry among lanthanides is known to be challenging. The therapeutic 161Tb is instead produced in nuclear reactors, exploiting the 160Gd(n,γ)161Gd→161Tb route. Considering the charged particles induced reactions [136, 139, 140146], only deuterons can be competitive via the 160Gd(d,x)161Tb route (with a cross section of about 200 mb at ca. 10–15 MeV) [146], while the use of α-beams is possible, but curtailed by scarce availability and the low production yield of the natGd(α,x)161Tb reaction [140]. The 149Tb radionuclide, under the spotlight of the international community as α-emitter, can be produced with high-energy protons [147, 148]: in this case the coproduction of Tb-isotopes cannot be avoided, requiring the use of a mass separation method (either on-line or off-line) to select the desired radionuclide. The 152Tb case is interesting since it is possible to compare the cross sections measured using proton, deuteron and α-beams on 151Eu and natGd targets [137, 142147]. A promising production route may be the natGd(d,x)152Tb reaction, that was measured up to 50 MeV obtaining an increasing trend with the maximum value of ca. 100 mb; however, the coproduction of contaminants has to be carefully evaluated. As for the 47Sc case, it is particularly useful for the Tb-isotopes to take into account the possibility to use the mass separation method, as proposed by the ISOLDE-MEDICIS collaboration [94] and the PRISMAP consortium [95], to maximize the production yield and the final radionuclidic purity.

Reliable nuclear codes are useful tools to describe the production of the radionuclides difficult to be measured (such as stable isotopes, long-lived or short-lived radionuclides, etc.) and to evaluate their impact on the final product quality. Most of the available nuclear codes reproduce quite well the low-energy region of proton induced reactions. However, in the estimation of more exotic reactions induced by either high-energy protons or heavier projectiles (such as deuteron and α particles) there is room for improvements. This is also partly due to the scarce availability of experimental data to constrain the nuclear codes in these regimes, another indication that further investigations are needed.

Considering the future availability of multi-particle accelerators and high-intensity beams, possibly coupled to mass separation techniques, it is foreseen that precise and complete set of cross section measurements will be needed to identify the best production route for the radionuclides of interest.

Corresponding authors: Gaia Pupillo, Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro (INFN-LNL), Viale dell’Università 2, 35020 Legnaro (PD), Italy, E-mail: ; and Simone Manenti, Department of Physics, University of Milan, Via Celoria 16, I-20133, Milano, Italy; and Department of Physics, Laboratorio Acceleratori e Superconduttività Applicata (LASA), University of Milan and INFN-Milan, Via F.lli Cervi 201, I-20090, Segrate, Italy, E-mail:

Funding source: CNRS

Award Identifier / Grant number: recurrent funding

Funding source: INSERM

Award Identifier / Grant number: recurrent funding

Funding source: INCa

Award Identifier / Grant number: INCa-DGOS-Inserm_12558

Funding source: Nantes Université

Award Identifier / Grant number: recurrent funding

Funding source: French National Agency for research

Award Identifier / Grant number: ANR-11-EQPX-0004, ANR-11-LABX-18-01 and ANR-16-IDEX-007

Funding source: INFN

Award Identifier / Grant number: recurrent funding

Funding source: Italian Ministry of Education and Research (MUR)

Award Identifier / Grant number: 0000450-08/01/2014-SCCLA-Y31PREV-A, 0015764-05/05/2016-SCCLA-Y31PREV-A

  1. Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: The National Institute of Nuclear Physics (INFN) of Italy has funded these research activities in the mainframe of projects approved by Interdisciplinary National Scientific Commission five since the eighties. The LARAMED project is funded by the Italian Ministry of Education, Universities and Research and it is based at the INFN Legnaro National Laboratories. The cyclotron Arronax is supported by CNRS, Inserm, INCa, the Nantes University, the Regional Council of Pays de la Loire, local authorities, the French government and the European Union. This work has been, in part, supported by a grant from the French National Agency for Research called “Investissements d’Avenir”, Equipex Arronax-Plus noANR-11-EQPX-0004, Labex IRON noANR-11-LABX-18-01 and ISITE NExT no ANR-16-IDEX-007.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

  4. Employment or leadership: None declared.

  5. Honorarium: None declared.


1. 2016-2022 World Nuclear Association, registered in England and Wales, number 01215741. Registered office: Tower House, 10 Southampton Street, London, WC2E 7HA, United Kingdom. Radioisotopes in medicine|nuclear medicine. in Google Scholar

2. Qaim, S. M. Medical Radionuclide Production, Science and Technology; De Gruyter: Berlin/Boston, 2020.10.1515/9783110604375Search in Google Scholar

3. Qaim, S.M. Nuclear data relevant to cyclotron produced short-lived medical radioisotopes. Radiochim. Acta 1982, 30, 147.Search in Google Scholar

4. Qaim, S. M. Theranostic radionuclides: recent advances in production methodologies. J. Radioanal. Nucl. Chem. 2019, 322, 1257.10.1007/s10967-019-06797-ySearch in Google Scholar

5. Qaim, S. M., Scholten, B., Neumaier, B. New developments in the production of theranostic pairs of radionuclides. J. Radioanal. Nucl. Chem. 2018, 318, 1493.10.1007/s10967-018-6238-xSearch in Google Scholar

6. Herzog, H., Rösch, F., Stöcklin, G., Lueders, C., Qaim, S. M., Feinendegen, L. E. Measurement of pharmacokinetics of yttrium-86 radiopharmaceuticals with PET and radiation dose calculation of analogous yttrium-90 radiotherapeutics. J. Nucl. Med. 1993, 34, 2222.Search in Google Scholar

7. Srivastava, S. A bridge not too far: personalized medicine with the use of theragnostic radiopharmaceuticals. J. Postgrad. Med. Educ. Res. 2013, 47, 31.10.5005/jp-journals-10028-1054Search in Google Scholar

8. Qaim, S. M. Nuclear data for production and medical application of radionuclides: present status and future needs. Nucl. Med. Biol. 2017, 44, 31.10.1016/j.nucmedbio.2016.08.016Search in Google Scholar PubMed

9. Qaim, S. M., Hussain, M., Spahn, I., Neumaier, B. Continuing nuclear data research for production of accelerator-based novel radionuclides for medical use: a mini-review. Front. Phys. 2021, 9, 639290.10.3389/fphy.2021.639290Search in Google Scholar

10. Merrick, M. J., Rotsch, D. A., Tiwari, A., Nolen, J., Brossard, T., Song, J., Wadas, T. J., Sunderland, J. J., Graves, S. A. Imaging and dosimetric characteristics of 67Cu. Phys. Med. Biol. 2021, 66, 035002.10.1088/1361-6560/abca52Search in Google Scholar PubMed

11. Loveless, C. S., Radford, L. L., Ferran, S. J., Queern, S. L., Shepherd, M. R., Lapi, S. E. Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide 47Sc. EJNMMI Res. 2019, 9, 42.10.1186/s13550-019-0515-8Search in Google Scholar PubMed PubMed Central

12. Kazakov, A. G., Ekatova, T. Y., Babenya, J. S. Photonuclear production of medical radiometals: a review of experimental studies. J. Radioanal. Nucl. Chem. 2021, 328, 493.10.1007/s10967-021-07683-2Search in Google Scholar

13. IAEA. Cyclotron produced radionuclides: principles and practice. Technical Reports Series No 2008, 465. in Google Scholar

14. Qaim, S. M., Spahn, I., Scholten, B., Neumaier, B. Uses of alpha particles, especially in nuclear reaction studies and medical radionuclide production. Radiochim. Acta 2016, 104, 601.10.1515/ract-2015-2566Search in Google Scholar

15. Haddad, F., Ferrer, L., Guertin, A., Carlier, T., Michel, N., Barbet, J., Chatal, J.-F. ARRONAX, a high-energy and high-intensity cyclotron for nuclear medicine. Eur. J. Nucl. Med. Mol. Imag. 2008, 35, 1377.10.1007/s00259-008-0802-5Search in Google Scholar PubMed

16. Esposito, J., Bettoni, D., Boschi, A., Calderolla, M., Cisternino, S., Fiorentini, G., Keppel, G., Martini, P., Maggiore, M., Mou, L., Pasquali, M., Pranovi, L., Pupillo, G., Rossi Alvarez, C., Sarchiapone, L., Sciacca, G., Skliarova, H., Favaron, P., Lombardi, A., Antonini, P., Duatti, A. LARAMED: a laboratory for radioisotopes of medical interest. Molecules 2019, 24, 20.10.3390/molecules24010020Search in Google Scholar PubMed PubMed Central

17. IAEA. Cyclotron produced radionuclides: physical characteristics and production methods. 2009, in Google Scholar

18. Groppi, F., Bonardi, L. M., Bonardi, L., Alfassi, Z. B. Preparation of radionuclides and their measurement by high resolution γ-spectrometry, β-spectrometry and high resolution α-spectrometry. In NATO Science for Peace and Security Series B: Physics and Biophysics, 2009.10.1007/978-1-4020-9600-6_21Search in Google Scholar

19. Koning, A. J., Akkermans, J. M. Pre-equilibrium nuclear reactions: an introduction to classical and quantum-mechanical models. In Proceedings of the Workshop: Nuclear reaction data and nuclear reactors; World Scientific: Singapore, 1999; pp. 143–158.Search in Google Scholar

20. Goriely, S., Hilaire, S., Koning, A. J. Improved Predictions of Nuclear Reaction Rates with the TALYS Reaction Code for Astrophysical Applications; Astronomy & Astrophysics, 487, 2008; p. 767.10.1051/0004-6361:20078825Search in Google Scholar

21. Koning, A. J., Rochman, D. Modern nuclear data evaluation with the TALYS code system. Nucl. Data Sheets 2012, 113, 2841.10.1016/j.nds.2012.11.002Search in Google Scholar

22. Herman, M., Capote, R., Carlson, B. V., Obložinský, P., Sin, M., Trkov, A., Wienke, H., Zerkin, V. EMPIRE: nuclear reaction model code system for data evaluation. Nucl. Data Sheets 2007, 108, 2655.10.1016/j.nds.2007.11.003Search in Google Scholar

23. Böhlen, T. T., Cerutti, F., Chin, M. P. W., Fassò, A., Ferrari, A., Ortega, P. G., Mairani, A., Sala, P. R., Smirnov, G., Vlachoudis, V. The FLUKA code: developments and challenges for high energy and medical applications. Nucl. Data Sheets 2014, 120, 211.10.1016/j.nds.2014.07.049Search in Google Scholar

24. Ferrari, A., Sala, P. R., Fasso, A., Ranft, J. FLUKA: A Multi-Particle Transport Code; SLAC National Accelerator Lab: Menlo Park, CA (United States), 2005.10.2172/877507Search in Google Scholar

25. Pelowitz, D. B., Durkee, J. W., Elson, J. S., Fensin, M. L., Hendricks, J. S., James, M. R., Johns, R. C., McKinney, G. W., Mashnik, S. G., Verbeke, J. S., Waters, L. S., Wilcox, T. A. MCNPX 2.7.0 extensions. 2011. in Google Scholar

26. Koning, A. ISOTOPIA-1.0: simulation of medical isotope production with accelerators. 2019. in Google Scholar

27. TENDL-2021 nuclear data library. in Google Scholar

28. Barbaro, F., Canton, L., Carante, M. P., Colombi, A., De Dominicis, L., Fontana, A., Haddad, F., Mou, L., Pupillo, G. New results on proton-induced reactions on vanadium for 47Sc production and the impact of level densities on theoretical cross sections. Phys. Rev. C 2021, 104, 044619.10.1103/PhysRevC.104.044619Search in Google Scholar

29. Synowiecki, M. A., Perk, L. R., Nijsen, J. F. W. Production of novel diagnostic radionuclides in small medical cyclotrons. Eur. J. Nucl. Med. Mol. I 2018, 3, 3.10.1186/s41181-018-0038-zSearch in Google Scholar PubMed PubMed Central

30. Gales, S. SPIRAL2 at GANIL: next generation of ISOL facility for intense secondary radioactive ion beams. Nucl. Phys. 2010, 834, 717c.10.1016/j.nuclphysa.2010.01.130Search in Google Scholar

31. Pichoff, N., Bredy, P., Ferrand, G., Girardot, P., Gougnaud, F., Jacquemet, M., Mosnier, A., Bertrand, P., Di Giacomo, M., Ferdinand, R., Berkovits, D., Luner, J., Rodnizki, J. The SARAF-LINAC Project for SARAF-PHASE 2. In 6th International Particle Accelerator Conference (IPAC2015); JACoW Publishing: Richmond, VA, USA, 2015; pp. 3683–3685.Search in Google Scholar

32. Alliot, C., Audouin, N., Barbet, J., Bonraisin, A.-C., Bossé, V., Bourdeau, C., Bourgeois, M., Duchemin, C., Guertin, A., Haddad, F., Huclier-Markai, S., Kerdjoudj, R., Laizé, J., Métivier, V., Michel, N., Mokili, M., Pageau, M., Vidal, A. Is there an interest to use deuteron beams to produce non-conventional radionuclides? Front. Med. 2015, 2, 1–7; in Google Scholar PubMed PubMed Central

33. Šimečková, E., Bém, P., Honusek, M., Štefánik, M., Fischer, U., Simakov, S. P., Forrest, R. A., Koning, A. J., Sublet, J.-C., Avrigeanu, M., Roman, F. L., Avrigeanu, V. Low and medium energy deuteron-induced reactions on 63,65Cu nuclei. Phys. Rev. C 2011, 84, 014605.10.1103/PhysRevC.84.014605Search in Google Scholar

34. Baron, N., Cohen, B. L. Activation cross-section survey of deuteron-induced reactions. Phys. Rev. 1963, 129, 2636.10.1103/PhysRev.129.2636Search in Google Scholar

35. Avrigeanu, M., Avrigeanu, V., Mǎnǎilescu, C. On reaction mechanisms involved in the deuteron-induced surrogate reactions. AIP Conference Proceedings 2015, 1645, 139.10.1063/1.4909568Search in Google Scholar

36. National Nuclear Data Center (NNDC) at Brookhaven National Laboratory. NuDat, 3. in Google Scholar

37. Charged-particle cross section database for medical radioisotope production and beam monitor reactions. in Google Scholar

38. IAEA. Nuclear data for the production of therapeutic radionuclides. 2011. in Google Scholar

39. Engle, J. W., Ignatyuk, A. V., Capote, R., Carlson, B. V., Hermanne, A., Kellett, M. A., Kibédi, T., Kim, G., Kondev, F. G., Hussain, M., Lebeda, O., Luca, A., Nagai, Y., Naik, H., Nichols, A. L., Nortier, F. M., Suryanarayana, S. V., Takács, S., Tárkányi, F. T., Verpelli, M. Recommended nuclear data for the production of selected therapeutic radionuclides. Nucl. Data Sheets 2019, 155, 56.10.1016/j.nds.2019.01.003Search in Google Scholar

40. NDS, IAEA, Experimental nuclear reaction data (EXFOR). in Google Scholar

41. NDS, IAEA. Therapeutic radiopharmaceuticals labelled with copper-67, rhenium-186 and scandium-47. 2021. in Google Scholar

42. Jalilian, A. R., Gizawy, M. A., Alliot, C., Takacs, S., Chakarborty, S., Rovais, M. R. A., Pupillo, G., Nagatsu, K., Park, J. H., Khandaker, M. U., Mikolajczak, R., Bilewicz, A., Okarvi, S., Gagnon, K., Al Rayyes, A. H., Lapi, S. E., Starovoitova, V., Korde, A., Osso, J. A. IAEA activities on 67Cu, 186Re, 47Sc theranostic radionuclides and radiopharmaceuticals. Curr. Rad. 2021, 14, 306.10.2174/1874471013999200928162322Search in Google Scholar PubMed

43. Aslam, M., Sudár, S., Hussain, M., Malik, A. A., Shah, H. A., Qaim, S. M. Charged particle induced reaction cross section data for production of the emerging medically important positron emitter 64Cu: a comprehensive evaluation. Radiochim. Acta 2009, 97, 669.10.1524/ract.2009.1670Search in Google Scholar

44. Bonardi, M. L., Groppi, F., Mainardi, H. S., Kokhanyuk, V. M., Lapshina, E. V., Mebel, M. V., Zhuikov, B. L. Cross section studies on 64Cu with zinc target in the proton energy range from 141 down to 31 MeV. J. Radioanal. Nucl. Chem. 2005, 264, 101.10.1007/s10967-005-0681-1Search in Google Scholar

45. Mou, L., Martini, P., Pupillo, G., Cieszykowska, I., Cutler, C. S., Mikołajczak, R. 67Cu production capabilities: a mini review. Molecules 2022, 27, 1501.10.3390/molecules27051501Search in Google Scholar

46. Qaim, S. M. The present and future of medical radionuclide production. Radiochim. Acta 2012, 100, 635.10.1524/ract.2012.1966Search in Google Scholar

47. De Nardo, L., Pupillo, G., Mou, L., Esposito, J., Rosato, A., Meléndez-Alafort, L. A feasibility study of the therapeutic application of a mixture of 67/64Cu radioisotopes produced by cyclotrons with proton irradiation. Med. Phys. 2022, 49, 2709–2724.10.1002/mp.15524Search in Google Scholar

48. Szelecsényi, F., Steyn, G. F., Dolley, S. G., Kovács, Z., Vermeulen, C., van der Walt, T. Investigation of the 68Zn(p,2p)67Cu nuclear reaction: new measurements up to 40 MeV and compilation up to 100 MeV. Nucl. Instrum. Methods Phys. Res., Sect. B 2009, 267, 1877.10.1016/j.nimb.2009.03.097Search in Google Scholar

49. Stoll, T., Kastleiner, S., Shubin, Y. N., Coenen, H. H., Qaim, S. M. Excitation functions of proton induced reactions on 68Zn from threshold up to 71 MeV, with specific reference to the production of 67Cu. Radiochim. Acta 2002, 90, 309.10.1524/ract.2002.90.6.309Search in Google Scholar

50. Levkovski, V. N. Cross Sections of Medium Mass Nuclide Activation (A=40-100) by Medium Energy Protons and Alpha-Particles (E=10-50 MeV); Intervesy: Moscow, USSR, 1991.Search in Google Scholar

51. McGee, T., Rao, C., Saha, G., Yaffe, L. Nuclear interactions of 45Sc and 68Zn with protons of medium energy. Nucl. Phys. 1970, A150, 11–29.10.1016/0375-9474(70)90451-3Search in Google Scholar

52. Morrison, D. L., Caretto, A. A. Recoil study of the Zn68(p,2p)Cu67 reaction. Phys. Rev. 1964, 133, B1165.10.1103/PhysRev.133.B1165Search in Google Scholar

53. Cohen, B. L., Newman, E., Handley, T. H. (p,pn)+(p,2n) and (p,2p) cross sections in medium weight elements. Phys. Rev. 1955, 99, 723.10.1103/PhysRev.99.723Search in Google Scholar

54. Pupillo, G., Sounalet, T., Michel, N., Mou, L., Esposito, J., Haddad, F. New production cross sections for the theranostic radionuclide 67Cu. Nucl. Instrum. Methods Phys. Res., Sect. B 2018, 415, 41.10.1016/j.nimb.2017.10.022Search in Google Scholar

55. Kastleiner, S., Coenen, H. H., Qaim, S. M. Possibility of production of 67Cu at a small-sized cyclotron via the (p,α)-reaction on enriched 70Zn. Radiochim. Acta 1999, 84, 107.10.1524/ract.1999.84.2.107Search in Google Scholar

56. Pupillo, G., Mou, L., Martini, P., Pasquali, M., Boschi, A., Cicoria, G., Duatti, A., Haddad, F., Esposito, J. Production of 67Cu by enriched 70Zn targets: first measurements of formation cross sections of 67Cu, 64Cu, 67Ga, 66Ga, 69mZn and 65Zn in interactions of 70Zn with protons above 45 MeV. Radiochim. Acta 2020, 108, 593.10.1515/ract-2019-3199Search in Google Scholar

57. Kozempel, J., Abbas, K., Simonelli, F., Bulgheroni, A., Holzwarth, U., Gibson, N. Preparation of 67Cu via deuteron irradiation of 70Zn. Radiochim. Acta 2012, 100, 419.10.1524/ract.2012.1939Search in Google Scholar

58. Nigron, E., Guertin, A., Haddad, F., Sounalet, T. Is 70Zn(d, x)67Cu the best way to produce 67Cu for medical applications? Front. Med. 2021, 8, 674617.10.3389/fmed.2021.674617Search in Google Scholar

59. Skakun, Ye., Qaim, S. M. Excitation function of the 64Ni(α,p)67Cu reaction for production of 67Cu. Appl. Radiat. Isot. 2004, 60, 33.10.1016/j.apradiso.2003.09.003Search in Google Scholar

60. Tanaka, S. Reactions of nickel with alpha-particles. J. Phys. Soc. Jpn. 1960, 15, 2159.10.1143/JPSJ.15.2159Search in Google Scholar

61. Takács, S., Aikawa, M., Haba, H., Komori, Y., Ditrói, F., Szűcs, Z., Saito, M., Murata, T., Sakaguchi, M., Ukon, N. Cross sections of alpha-particle induced reactions on natNi: production of 67Cu. Nucl. Instrum. Methods Phys. Res., Sect. B 2020, 479, 125.10.1016/j.nimb.2020.06.022Search in Google Scholar

62. Antropov, A. E., Zarubin, P. P., Aleksandrov, Y. A., Gorshkov, I. Y. Study of the cross section for the reactions (p, n), (α,pn), (α,xn) on medium weight nuclei. Presented at the Conf. Nucl. Spectr. and Nucl. Struct., Leningrad, USSR 1985, 369.Search in Google Scholar

63. Ohya, T., Nagatsu, K., Suzuki, H., Fukada, M., Minegishi, K., Hanyu, M., Zhang, M.-R. Small-scale production of 67Cu for a preclinical study via the 64Ni(α,p)67Cu channel. Nucl. Med. Biol. 2018, 59, 56.10.1016/j.nucmedbio.2018.01.002Search in Google Scholar

64. NIDC: National Isotope Development Center. in Google Scholar

65. Merrick, M. J., Rotsch, D. A., Tiwari, A., Nolen, J., Brossard, T., Song, J., Wadas, T. J., Sunderland, J., Graves, S. Imaging and dosimetric characteristics of 67Cu. Phys. Med. Biol. 2020, 66, 035002.10.1088/1361-6560/abca52Search in Google Scholar

66. Müller, C., Domnanich, K. A., Umbricht, C. A., van der Meulen, N. P. Scandium and terbium radionuclides for radiotheranostics: current state of development towards clinical application. Br. J. Radiol. 2018, 91, 20180074.10.1259/bjr.20180074Search in Google Scholar

67. Gadioli, E., Gadioli Erba, E., Hogan, J. J., Burns, K. I. Emission of alpha particles in the interaction of 10 85 MeV protons with 48,50Ti. Z. Phys. A-Hadron. Nucl. 1981, 301, 289.10.1007/BF01421692Search in Google Scholar

68. Pupillo, G., Fontana, A., Canton, L., Haddad, F., Skliarova, H., Cisternino, S., Martini, P., Pasquali, M., Boschi, A., Esposito, J., Duatti, A., Mou, L. Preliminary results of the PASTA project. Il Nuovo Cimento C 2019, 42, 1.Search in Google Scholar

69. Carzaniga, T. S., Braccini, S. Cross-section measurement of 44mSc,47Sc, 48Sc and 47Ca for an optimized 47Sc production with an 18 MeV medical PET cyclotron. Appl. Radiat. Isot. 2019, 143, 18.10.1016/j.apradiso.2018.10.015Search in Google Scholar

70. Michel, R., Peiffer, F., Stück, R. Measurement and hybrid model analysis of integral excitation functions for proton-induced reactions on vanadium, manganese and cobalt up to 200 MeV. Nucl. Phys. 1985, 441, 617.10.1016/0375-9474(85)90441-5Search in Google Scholar

71. Michel, R., Brinkmann, G., Weigel, H., Herr, W. Measurement and hybrid-model analysis of proton-induced reactions with V, Fe and Co. Nucl. Phys. 1979, 322, 40.10.1016/0375-9474(79)90332-4Search in Google Scholar

72. Ditrói, F., Tárkányi, F., Takács, S., Hermanne, A. Activation cross-sections of proton induced reactions on vanadium in the 37–65 MeV energy range. Nucl. Instrum. Methods Phys. Res., Sect. B 2016, 381, 16.10.1016/j.nimb.2016.05.015Search in Google Scholar

73. Pupillo, G., Mou, L., Boschi, A., Calzaferri, S., Canton, L., Cisternino, S., De Dominicis, L., Duatti, A., Fontana, A., Haddad, F., Martini, P., Pasquali, M., Skliarova, H., Esposito, J. Production of 47Sc with natural vanadium targets: results of the PASTA project. J. Radioanal. Nucl. Chem. 2019, 322, 1711.10.1007/s10967-019-06844-8Search in Google Scholar

74. Pupillo, G., Mou, L., Boschi, A., Calzaferri, S., Canton, L., Cisternino, S., De Dominicis, L., Duatti, A., Fontana, A., Haddad, F., Martini, P., Pasquali, M., Skliarova, H., Esposito, J. Correction to: production of 47Sc with natural vanadium targets: results of the PASTA project. J. Radioanal. Nucl. Chem. 2021, 328, 1407.10.1007/s10967-021-07791-zSearch in Google Scholar

75. Nardo, L. D., Pupillo, G., Mou, L., Furlanetto, D., Rosato, A., Esposito, J., Meléndez-Alafort, L. Preliminary dosimetric analysis of DOTA-folate radiopharmaceutical radiolabelled with 47Sc produced through natV(p,x)47Sc cyclotron irradiation. Phys. Med. Biol. 2021, 66, 025003.10.1088/1361-6560/abc811Search in Google Scholar

76. Meléndez-Alafort, L., Ferro-Flores, G., De Nardo, L., Bello, M., Paiusco, M., Negri, A., Zorz, A., Uzunov, N., Esposito, J., Rosato, A. Internal radiation dose assessment of radiopharmaceuticals prepared with cyclotron-produced 99mTc. Med. Phys. 2019, 46, 1437.10.1002/mp.13393Search in Google Scholar

77. Duchemin, C., Guertin, A., Haddad, F., Michel, N., Métivier, V. Cross section measurements of deuteron induced nuclear reactions on natural tungsten up to 34 MeV. Appl. Radiat. Isot. 2015, 97, 52.10.1016/j.apradiso.2014.12.011Search in Google Scholar

78. Gagnon, K., Avila-Rodriguez, M. A., Wilson, J., McQuarrie, S. A. Experimental deuteron cross section measurements using single natural titanium foils from 3 to 9 MeV with special reference to the production of 47V and 51Ti. Nucl. Instrum. Methods Phys. Res., Sect. B 2010, 268, 1392.10.1016/j.nimb.2010.01.025Search in Google Scholar

79. Takács, S., Király, B., Tárkányi, F., Hermanne, A. Evaluated activation cross sections of longer-lived radionuclides produced by deuteron induced reactions on natural titanium. Nucl. Instrum. Methods Phys. Res., Sect. B 2007, 262, 7.10.1016/j.nimb.2007.05.011Search in Google Scholar

80. Hermanne, A., Sonck, M., Takács, S., Tárkányi, F. Experimental study of excitation functions for some reactions induced by deuterons (10–50 MeV) on natural Fe and Ti. Nucl. Instrum. Methods Phys. Res., Sect. B 2000, 161–163, 178.10.1016/S0168-583X(99)00987-8Search in Google Scholar

81. Takácss, S., Sonck, M., Scholten, B., Hermanne, A., Tárkányi, F. Excitation functions of deuteron induced nuclear reactions on natTi up to 20 MeV for monitoring deuteron beams. Appl. Radiat. Isot. 1997, 48, 657.10.1016/S0969-8043(97)00001-8Search in Google Scholar

82. Lebeda, O., Štursa, J., Ráliš, J. Experimental cross-sections of deuteron-induced reaction on 89Y up to 20 MeV; comparison of natTi(d, x)48V and 27Al(d,x)24Na monitor reactions. Nucl. Instrum. Methods Phys. Res., Sect. B 2015, 360, 118.10.1016/j.nimb.2015.08.036Search in Google Scholar

83. Khandaker, M. U., Haba, H., Kanaya, J., Otuka, N. Excitation functions of (d,x) nuclear reactions on natural titanium up to 24 MeV. Nucl. Instrum. Methods Phys. Res., Sect. B 2013, 296, 14.10.1016/j.nimb.2012.12.003Search in Google Scholar

84. Khandaker, M. U., Haba, H., Kanaya, J., Otuka, N., Kassim, H. A. Activation cross-sections of deuteron-induced nuclear reactions on natural titanium. Nucl. Data Sheets 2014, 119, 252.10.1016/j.nds.2014.08.069Search in Google Scholar

85. Hermanne, A., Tárkányi, F., Takács, S., Ditrói, F., Amjed, N. Excitation functions for production of 46Sc by deuteron and proton beams in natTi: a basis for additional monitor reactions. Nucl. Instrum. Methods Phys. Res., Sect. B 2014, 338, 31.10.1016/j.nimb.2014.07.026Search in Google Scholar

86. Jung, P. Helium production and long-term activation by protons and deuterons in metals for fusion reactor application. J. Nucl. Mater. 1987, 144, 43.10.1016/0022-3115(87)90278-9Search in Google Scholar

87. Chen, K. L., Miller, J. M. Comparison between reactions of alpha particles with scandium-45 and deuterons with titanium-47. Phys. Rev. 1964, 134, B1269.10.1103/PhysRev.134.B1269Search in Google Scholar

88. Anders, O. U., Meinke, W. W. Absolute (d,α)-reaction cross sections of zirconium, molybdenum, titanium, and sulfur. Phys. Rev. 1960, 120, 2114.10.1103/PhysRev.120.2114Search in Google Scholar

89. Hall, K. L., Meinke, W. W. Determination of (d,alpha) reaction cross-sections. J. Inorg. Nucl. Chem. 1959, 9, 193–199.10.1016/0022-1902(59)80221-9Search in Google Scholar

90. Sonzogni, A. A., Romo, A. S. M. A., Mosca, H. O., Nassiff, S. J. Alpha and deuteron induced reactions on vanadium. J. Radioanal. Nucl. Chem. 1993, 170, 143.10.1007/BF02134585Search in Google Scholar

91. Qaim, S. M., Probst, H. J. Excitation functions of deuteron induced nuclear reactions on vanadium with special reference to the production of 43K: systematics of (d,xn) reaction cross sections relevant to the formation of highly neutron deficient radioisotopes. Radiochim. Acta 1984, 35, 11.10.1524/ract.1984.35.1.11Search in Google Scholar

92. Tárkányi, F., Ditrói, F., Takács, S., Hermanne, A., Baba, M., Ignatyuk, A. V. Investigation of activation cross-sections of deuteron induced reactions on vanadium up to 40 MeV. Nucl. Instrum. Methods Phys. Res., Sect. B 2011, 269, 1792.10.1016/j.nimb.2011.05.003Search in Google Scholar

93. Minegishi, K., Nagatsu, K., Fukada, M., Suzuki, H., Ohya, T., Zhang, M.-R. Production of scandium-43 and -47 from a powdery calcium oxide target via the nat/44Ca(α,x)-channel. Appl. Radiat. Isot. 2016, 116, 8.10.1016/j.apradiso.2016.07.017Search in Google Scholar PubMed

94. Duchemin, C., Ramos, J. P., Stora, T., Ahmed, E., Aubert, E., Audouin, N., Barbero, E., Barozier, V., Bernardes, A.-P., Bertreix, P., Boscher, A., Bruchertseifer, F., Catherall, R., Chevallay, E., Christodoulou, P., Chrysalidis, K., Cocolios, T. E., Comte, J., Crepieux, B., Deschamps, M., Dockx, K., Dorsival, A., Fedosseev, V. N., Fernier, P., Formento-Cavaier, R., El Idrissi, S., Ivanov, P., Gadelshin, V. M., Gilardoni, S., Grenard, J.-L., Haddad, F., Heinke, R., Juif, B., Khalid, U., Khan, M., Köster, U., Lambert, L., Lilli, G., Lunghi, G., Marsh, B. A., Palenzuela, Y. M., Martins, R., Marzari, S., Menaa, N., Michel, N., Munos, M., Pozzi, F., Riccardi, F., Riegert, J., Riggaz, N., Rinchet, J.-Y., Rothe, S., Russell, B., Saury, C., Schneider, T., Stegemann, S., Talip, Z., Theis, C., Thiboud, J., van der Meulen, N. P., van Stenis, M., Vincke, H., Vollaire, J., Vuong, N.-T., Webster, B., Wendt, K., Wilkins, S. G. The CERN-MEDICIS collaboration: CERN-MEDICIS: a review since commissioning in 2017. Front. Med. 2021, 8, 693682.10.3389/fmed.2021.693682Search in Google Scholar PubMed PubMed Central

95. PRISMAP — building a European network for medical radionuclides. in Google Scholar

96. Amjed, N., Wajid, A. M., Ahmad, N., Ishaq, M., Aslam, M. N., Hussain, M., Qaim, S. M. Evaluation of nuclear reaction cross sections for optimization of production of the important non-standard positron emitting radionuclide 89Zr using proton and deuteron induced reactions on 89Y target. Appl. Radiat. Isot. 2020, 165, 109338.10.1016/j.apradiso.2020.109338Search in Google Scholar PubMed

97. Cisternino, S., Cazzola, E., Skliarova, H., Amico, J., Malachini, M., Gorgoni, G., Anselmi-Tamburini, U., Esposito, J. Target manufacturing by spark plasma sintering for efficient 89Zr production. Nucl. Med. Biol. 2022, 104–105, 38.10.1016/j.nucmedbio.2021.11.004Search in Google Scholar PubMed

98. Manenti, S., Haddad, F., Groppi, F. New excitation functions measurement of nuclear reactions induced by deuteron beams on yttrium with particular reference to the production of 89Zr. Nucl. Instrum. Methods Phys. Res., Sect. B 2019, 458, 57.10.1016/j.nimb.2019.08.002Search in Google Scholar

99. IAEA. Charged particle cross-section database for medical radioisotope production: diagnostic radioisotopes and monitor reactions 2001, IAEA-TECDOC-1211. in Google Scholar

100. Hussain, M., Sudar, S., Aslam, M. N., Shah, H. A., Ahmad, R., Malik, A. A., Qaim, S. M. A comprehensive evaluation of charged-particle data for production of the therapeutic radionuclide 103Pd. Appl. Radiat. Isot. 2009, 67, 1842.10.1016/j.apradiso.2009.06.010Search in Google Scholar PubMed

101. Ali, B. M., Al-Abyad, M., Kandil, S., Solieman, A. H. M., Ditrói, F. Excitation functions of 3He-particle-induced nuclear reactions on 103Rh: experimental and theoretical investigations. Eur. Phys. J. Plus. 2018, 133, 9.10.1140/epjp/i2018-11838-xSearch in Google Scholar

102. Skakun, Ye., Qaim, S. M. Measurement of excitation functions of helion-induced reactions on enriched Ru targets for production of medically important 103Pd and 101mRh and some other radionuclides. Appl. Radiat. Isot. 2008, 66, 653.10.1016/j.apradiso.2007.11.013Search in Google Scholar PubMed

103. Boschi, A., Uccelli, L., Pasquali, M., Duatti, A., Taibi, A., Pupillo, G., Esposito, J. 188W/188Re generator system and its therapeutic applications. J. Chem. 2014, 2014, 529406.10.1155/2014/529406Search in Google Scholar

104. Tárkányi, F., Takács, S., Szelecsényi, F., Ditrói, F., Hermanne, A., Sonck, M. Excitation functions of proton induced nuclear reactions on natural tungsten up to 34 MeV. Nucl. Instrum. Methods Phys. Res., Sect. B 2006, 252, 160.10.1016/j.nimb.2006.09.010Search in Google Scholar

105. Shigeta, N., Matsuoka, H., Osa, A., Koizumi, M., Izumo, M., Kobayashi, K., Hashimoto, K., Sekine, T., Lambrecht, R. M. Production method of no-carrier-added 186Re. J Radioanal Nucl Ch 1996, 205, 85.10.1007/BF02040553Search in Google Scholar

106. Zhang, X., Li, W., Fang, K., He, W., Sheng, R., Ying, D., Hu, W. Excitation Functions for natW(p,xn)181-186Re Reactions and Production of No-Carrier-Added 186Re via 186W(p,n)186Re Reaction. Radiochim. Acta 1999, 86, 11.10.1524/ract.1999.86.12.11Search in Google Scholar

107. Lapi, S., Mills, W. J., Wilson, J., McQuarrie, S., Publicover, J., Schueller, M., Schyler, D., Ressler, J. J., Ruth, T. J. Production cross-sections of 181–186Re isotopes from proton bombardment of natural tungsten. Appl. Radiat. Isot. 2007, 65, 345.10.1016/j.apradiso.2006.08.015Search in Google Scholar

108. Khandaker, M. U., Uddin, M. S., Kim, K., Lee, M. W., Kim, K. S., Lee, Y. S., Kim, G. N., Cho, Y. S., Lee, Y. O. Excitation functions of proton induced nuclear reactions on natW up to 40 MeV. Nucl. Instrum. Methods Phys. Res., Sect. B 2008, 266, 1021.10.1016/j.nimb.2008.02.037Search in Google Scholar

109. Bonardi, M., Groppi, F., Persico, E., Manenti, S., Abbas, K., Holzwarth, U., Simonelli, F., Alfassi, Z. B. Excitation functions and yields for cyclotron production of radiorhenium via natW(p,†xn)181-186gRe nuclear reactions and tests on the production of 186gRe using enriched 186W. Radiochim. Acta 2011, 99, 1.10.1524/ract.2011.1789Search in Google Scholar

110. Manenti, S., Persico, E., Abbas, K., Bonardi, M. L., Gini, L., Groppi, F., Holzwarth, U., Simonelli, F. Excitation functions and yields for cyclotron production of radiorhenium via deuteron irradiation: natW(d,xn)181,182(A+B),183,184(m+g),186gRe nuclear reactions and tests on the production of 186gRe using enriched 186W. Radiochim. Acta 2014, 102, 669.10.1515/ract-2013-2194Search in Google Scholar

111. Tárkányi, F., Takács, S., Szelecsényi, F., Ditrói, F., Hermanne, A., Sonck, M. Excitation functions of deuteron induced nuclear reactions on natural tungsten up to 50 MeV. Nucl. Instrum. Methods Phys. Res., Sect. B 2003, 211, 319.10.1016/S0168-583X(03)01389-2Search in Google Scholar

112. Nassiff, S. J., Münzel, H. Cross sections for the Reactions 66Zn(d,n)67Ga, 52Cr(d,2n)52gMn and 186W (d,2n)186Re. Radiochim. Acta 1973, 19, 97.10.1524/ract.1973.19.3.97Search in Google Scholar

113. Pement, F. W., Wolke, R. L. Compound-statistical features of deuteron-induced reactions. ii. the compound nucleus and stripping-evaporation mechanisms in (d,2n) reactions. Nucl. Phys. 1966, 86, 429–442.10.1016/0029-5582(66)90550-5Search in Google Scholar

114. Zhenlan, T., Fuying, Z., Huiyuan, A. Q., Gongqing, W. Excitation functions for 182-186W(d,2n)182-186Re and 186W(d,p)187W reactions. Chin. J. Nucl. Phys. 1981, 3, 242.Search in Google Scholar

115. Ishioka, N. S., Watanabe, S., Osa, A., Koizumi, M., Matsuoka, H., Sekine, T. Excitation functions of rhenium isotopes on the natW(d,xn) reactions and production of No-carrier-added 186Re. J. Nucl. Sci. Technol. 2002, 39, 1334.10.1080/00223131.2002.10875351Search in Google Scholar

116. Khandaker, M. U., Nagatsu, K., Minegishi, K., Wakui, T., Zhang, M.-R., Otuka, N. Study of deuteron-induced nuclear reactions on natural tungsten for the production of theranostic 186Re via AVF cyclotron up to 38 MeV. Nucl. Instrum. Methods Phys. Res., Sect. B 2017, 403, 51.10.1016/j.nimb.2017.04.087Search in Google Scholar

117. Hussain, M., Sudár, S., Aslam, M. N., Malik, A. A., Ahmad, R., Qaim, S. M. Evaluation of charged particle induced reaction cross section data for production of the important therapeutic radionuclide 186Re. Radiochim. Acta 2010, 98, 385.10.1524/ract.2010.1733Search in Google Scholar

118. Bonardi, M. L., Groppi, F., Manenti, S., Persico, E., Gini, L. Production study of high specific activity NCA Re-186g by proton and deuteron cyclotron irradiation. Appl. Radiat. Isot. 2010, 68, 1595.10.1016/j.apradiso.2010.03.014Search in Google Scholar

119. Szelecsényi, F., Steyn, G. F., Kovács, Z., Aardaneh, K., Vermeulen, C., van der Walt, T. N. Production possibility of 186Re via the 192Os(p,α3n)186Re nuclear reaction. J. Radioanal. Nucl. Chem. 2009, 282, 261.10.1007/s10967-009-0147-ySearch in Google Scholar

120. Scott, N. E., Cobble, J. W., Daly, P. J. A comparison of reactions induced by medium-energy 3He and 4He ions in heavy target nuclei. Nucl. Phys. 1968, 119, 131.10.1016/0375-9474(68)90810-5Search in Google Scholar

121. Aliev, R. A., Zagryadskiy, V. A., Kormazeva, E. S., Latushkin, S. T., Malamut, T. Yu., Moiseeva, A. N., Novikov, V. I., Skobelin, I. I., Unezhev, V. N. Measurement of 186W(4He, p3n)186Re, 186W(4He, pn)188Re, 186W(4He,p)189Re reaction cross sections by 4He irradiation of 186W target. At. Energy 2021, 130, 36.10.1007/s10512-021-00770-3Search in Google Scholar

122. Lee, S. Y., Kim, C. Y., Nam, T.-G. Ruthenium complexes as anticancer agents: a brief history and perspectives. Drug Des. Dev. Ther. 2020, 14, 5375.10.2147/DDDT.S275007Search in Google Scholar PubMed PubMed Central

123. Zaitseva, N. G., Rurarz, E., Vobecký, M., Hwan, K. H., Nowak, K., Téthal, T., Khalkin, V. A., Popinenkova, L. M. Excitation function and yield for 97Ru production in 99Tc(p,3n)97Ru reaction in 20 – 100 MeV proton energy range. In Nuclear Data for Science and Technology; Qaim, S. M., Ed.; Springer: Berlin, Heidelberg, 1992; pp. 613–615.10.1007/978-3-642-58113-7_175Search in Google Scholar

124. Tárkányi, F., Ditrói, F., Takács, S., Csikai, J., Hermanne, A., Uddin, M. S., Baba, M. Activation cross sections of proton induced nuclear reactions on palladium up to 80 MeV. Appl. Radiat. Isot. 2016, 114, 128.10.1016/j.apradiso.2016.05.022Search in Google Scholar

125. Uddin, M. S., Hagiwara, M., Baba, M., Tarkanyi, F., Ditroi, F. Experimental studies on excitation functions of the proton-induced activation reactions on silver. Appl. Radiat. Isot. 2005, 62, 533.10.1016/j.apradiso.2004.10.011Search in Google Scholar

126. Ditrói, F., Tárkányi, F., Takács, S., Mahunka, I., Csikai, J., Hermanne, A., Uddin, M. S., Hagiwara, M., Baba, M., Ido, T., Shubin, Yu., Dityuk, A. I. Measurement of activation cross sections of the proton induced nuclear reactions on palladium. J. Radioanal. Nucl. Chem. 2007, 272, 231.10.1007/s10967-007-0506-5Search in Google Scholar

127. Comparetto, G., Qaim, S. M. A comparative study of the production of short-lived neutron deficient isotopes 94,95,97Ru in α- and 3He-particle induced nuclear reactions on natural molybdenum. Radiochim. Acta 1980, 27, 177.10.1524/ract.1980.27.4.177Search in Google Scholar

128. Esterlund, R. A., Pate, B. D. Analysis of excitation functions via the compound statistical model: angular momentum effects. Nucl. Phys. 1965, 69, 401.10.1016/0029-5582(65)90059-3Search in Google Scholar

129. Graf, H. P., Münzel, H. Excitation functions for α-particle reactions with molybdenum isotopes. J. Inorg. Nucl. Chem. 1974, 36, 3647.10.1016/0022-1902(74)80143-0Search in Google Scholar

130. Sitarz, M., Nigron, E., Guertin, A., Haddad, F., Matulewicz, T. New cross-sections for natMo(α,x) reactions and medical 97Ru production estimations with radionuclide yield calculator. Instruments 2019, 3, 7.10.3390/instruments3010007Search in Google Scholar

131. Ditrói, F., Hermanne, A., Tárkányi, F., Takács, S., Ignatyuk, A. V. Investigation of the α-particle induced nuclear reactions on natural molybdenum. Nucl. Instrum. Methods Phys. Res., Sect. B 2012, 285, 125.10.1016/j.nimb.2012.05.030Search in Google Scholar

132. Tárkányi, F., Hermanne, A., Ditrói, F., Takács, S., Ignatyuk, A. Investigation of activation cross section data of alpha particle induced nuclear reaction on molybdenum up to 40 MeV: review of production routes of medically relevant 97,103Ru. Nucl. Instrum. Methods Phys. Res., Sect. B 2017, 399, 83.10.1016/j.nimb.2017.03.043Search in Google Scholar

133. Henriksen, G., Messelt, S., Olsen, E., Larsen, R. H. Optimisation of cyclotron production parameters for the 209Bi(α,2n)211At reaction related to biomedical use of 211At. Appl. Radiat. Isot. 2001, 54, 839.10.1016/S0969-8043(00)00346-8Search in Google Scholar

134. Morzenti, S., Bonardi, M. L., Groppi, F., Zona, C., Persico, E., Menapace, E., Alfassi, Z. B. Cyclotron production of 211At/211gPo by 209Bi(α,2n) reaction. J. Radioanal. Nucl. Chem. 2008, 276, 843.10.1007/s10967-008-0642-6Search in Google Scholar

135. Groppi, F., Bonardi, M. L., Birattari, C., Menapace, E., Abbas, K., Holzwarth, U., Alfarano, A., Morzenti, S., Zona, C., Alfassi, Z. B. Optimisation study of α-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes. Appl. Radiat. Isot. 2005, 63, 621.10.1016/j.apradiso.2005.05.041Search in Google Scholar PubMed

136. Tárkányi, F., Ditrói, F., Takács, S., Csikai, J., Hermanne, A., Ignatyuk, A. V. Activation cross-sections of long lived products of deuteron induced nuclear reactions on dysprosium up to 50 MeV. Appl. Radiat. Isot. 2014, 83, 18.10.1016/j.apradiso.2013.10.011Search in Google Scholar PubMed

137. Tárkányi, F., Takács, S., Ditrói, F., Csikai, J., Hermanne, A., Ignatyuk, A. V. Activation cross-sections of deuteron induced reactions on natGd up to 50 MeV. Appl. Radiat. Isot. 2014, 83, 25.10.1016/j.apradiso.2013.10.010Search in Google Scholar PubMed

138. Tárkányi, F., Takács, S., Ditrói, F., Hermanne, A., Ignatyuk, A. V. Activation cross-sections of longer-lived radioisotopes of deuteron induced nuclear reactions on terbium up to 50 MeV. Nucl. Instrum. Methods Phys. Res., Sect. B 2013, 316, 183.10.1016/j.nimb.2013.09.008Search in Google Scholar

139. Szelecsényi, F., Kovács, Z., Nagatsu, K., Zhang, M.-R., Suzuki, K. Investigation of deuteron-induced reactions on natGd up to 30 MeV: possibility of production of medically relevant 155Tb and 161Tb radioisotopes. J. Radioanal. Nucl. Chem. 2016, 307, 1877.10.1007/s10967-015-4528-0Search in Google Scholar

140. Gayoso, R. E., Sonzogni, A. A., Nassiff, S. J. (α,pxn) reactions on natural gadolinium. Radiochim. Acta 1996, 72, 55.10.1524/ract.1996.72.2.55Search in Google Scholar

141. Mosca, H. O., Capurro, O., Vedoya, M. V., Nassiff, S Excitation functions and thick target yields of (α,αxn) and (α, 2pxn) reactions on 159Tb. J. Radioanal. Nucl. Chem. 1989, 131, 435–443.10.1007/BF02060609Search in Google Scholar

142. Duchemin, C., Guertin, A., Haddad, F., Michel, N., Métivier, V. Deuteron induced Tb-155 production, a theranostic isotope for SPECT imaging and auger therapy. Appl. Radiat. Isot. 2016, 118, 281.10.1016/j.apradiso.2016.09.030Search in Google Scholar PubMed

143. Favaretto, C., Talip, Z., Borgna, F., Grundler, P. V., Dellepiane, G., Sommerhalder, A., Zhang, H., Schibli, R., Braccini, S., Müller, C., van der Meulen, N. P. Cyclotron production and radiochemical purification of terbium-155 for SPECT imaging. Eur. J. Nucl. Med. Mol. I 2021, 6, 37.10.1186/s41181-021-00153-wSearch in Google Scholar PubMed PubMed Central

144. Tárkányi, F., Hermanne, A., Ditrói, F., Takács, S., Ignatyuk, A. V. Activation cross-sections of longer lived radioisotopes of proton induced nuclear reactions on terbium up to 65 MeV. Appl. Radiat. Isot. 2017, 127, 7.10.1016/j.apradiso.2017.04.030Search in Google Scholar PubMed

145. Engle, J. W., Mashnik, S. G., Parker, L. A., Jackman, K. R., Bitteker, L. J., Ullmann, J. L., Gulley, M. S., Pillai, C., John, K. D., Birnbaum, E. R., Nortier, F. M. Nuclear excitation functions from 40 to 200 MeV proton irradiation of terbium. Nucl. Instrum. Methods Phys. Res., Sect. B 2016, 366, 206.10.1016/j.nimb.2015.10.049Search in Google Scholar

146. Tárkányi, F., Hermanne, A., Takács, S., Ditrói, F., Csikai, J., Ignatyuk, A. V. Cross-section measurement of some deuteron induced reactions on 160Gd for possible production of the therapeutic radionuclide 161Tb. J. Radioanal. Nucl. Chem. 2013, 298, 1385.10.1007/s10967-013-2507-xSearch in Google Scholar

147. Moiseeva, A. N., Aliev, R. A., Unezhev, V. N., Gustova, N. S., Madumarov, A. S., Aksenov, N. V., Zagryadskiy, V. A. Alpha particle induced reactions on 151Eu: possibility of production of 152Tb radioisotope for PET imaging. Nucl. Instrum. Methods Phys. Res., Sect. B 2021, 497, 59.10.1016/j.nimb.2021.04.007Search in Google Scholar

148. Formento-Cavaier, R., Haddad, F., Alliot, C., Sounalet, T., Zahi, I. New excitation functions for proton induced reactions on natural gadolinium up to 70 MeV with focus on 149Tb production. Nucl. Instrum. Methods Phys. Res., Sect. B 2020, 478, 174.10.1016/j.nimb.2020.06.029Search in Google Scholar

Received: 2022-01-14
Accepted: 2022-04-14
Published Online: 2022-05-13
Published in Print: 2022-06-27

© 2022 Gaia Pupillo et al., published by De Gruyter, Berlin/Boston

This work is licensed under the Creative Commons Attribution 4.0 International License.

Downloaded on 25.9.2023 from
Scroll to top button