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BY-NC-ND 3.0 license Open Access Published by De Gruyter October 12, 2012

Metal ion sensors for trace determination of metals in drugs and pharmaceuticals

  • Rasiklal N. Guna , Jayant M. Vyas , Ajmeer Ramkishan and Yadvendra K. Agrawal EMAIL logo


The new specific metal sensors for copper, zinc, nickel, cobalt, iron, arsenic, antimony, bismuth, vanadium, molybdenum, selenium, and lead were synthesized by using N-phenyl[1,2 methane fullerene C60]C61 complexes. The metal sensors were characterized by pH range, electrode response, response time, and associated metals. The limit of detection of the sensors was found to range between 3×10-7 and 5×10-7, with lifetime between 6 and 8 months. These metal sensors were used for the detection and quantitative determination of trace metal impurities in drugs and pharmaceuticals.

Corresponding author: Yadvendra K. Agrawal, Institute of Research and Development, Gujarat Forensic Sciences University, Sector 18/A, Near Police Bhavan, Gandhinagar, Gujrat, India

Received: 2012-6-18
Accepted: 2012-9-12
Published Online: 2012-10-12
Published in Print: 2012-11-01

©2012 by Walter de Gruyter Berlin Boston

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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