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BY-NC-ND 3.0 license Open Access Published by De Gruyter May 20, 2011

Study of Zn(II)-coumarin complex by electrochemical method with increased anticoagulant potency

  • Rakesh Choure EMAIL logo , Neelam Vaidya and Krishna Sadashiv Pitre


The formation of complexes of coumarin and Zn(II) was studied in aqueous media at pH 8.2±0.1 by polarography and spectroscopy. The polarogram indicated formation of complexes between coumarin and Zn(II). Coumarin produces a well-defined direct current polarogram and differential pulse polarogram in 1 m ammonium tartrate (supporting electrolyte) at pH 8.2±0.1. The stoichiometry of the Zn(II)-coumarin complex is 1:1. Anticoagulant studies on the drug and its metal complex have been performed in albino mice, revealing the complex to be more potent in anticoagulation activity compared to the parent drug.

Published Online: 2011-05-20
Published in Print: 2011-06-01

©2011 by Walter de Gruyter Berlin Boston

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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